CA2274063A1 - Composes pyrimidines substitues et leur utilisation - Google Patents
Composes pyrimidines substitues et leur utilisation Download PDFInfo
- Publication number
- CA2274063A1 CA2274063A1 CA002274063A CA2274063A CA2274063A1 CA 2274063 A1 CA2274063 A1 CA 2274063A1 CA 002274063 A CA002274063 A CA 002274063A CA 2274063 A CA2274063 A CA 2274063A CA 2274063 A1 CA2274063 A1 CA 2274063A1
- Authority
- CA
- Canada
- Prior art keywords
- compounds
- diseases
- substituted pyrimidine
- maladies
- prophylaxis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108090001005 Interleukin-6 Proteins 0.000 abstract 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3212896P | 1996-12-05 | 1996-12-05 | |
| US60/032,128 | 1996-12-05 | ||
| US5095097P | 1997-06-13 | 1997-06-13 | |
| US60/050,950 | 1997-06-13 | ||
| US97605497A | 1997-11-21 | 1997-11-21 | |
| US08/976,054 | 1997-11-21 | ||
| PCT/US1997/022390 WO1998024782A2 (fr) | 1996-12-05 | 1997-12-04 | Composes pyrimidines substitues et leur utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2274063A1 true CA2274063A1 (fr) | 1998-06-11 |
| CA2274063C CA2274063C (fr) | 2007-09-04 |
Family
ID=27364030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002274063A Expired - Fee Related CA2274063C (fr) | 1996-12-05 | 1997-12-04 | Composes pyrimidines substitues et leur utilisation |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0948497A2 (fr) |
| CN (1) | CN1246858A (fr) |
| AR (1) | AR048564A1 (fr) |
| AU (1) | AU733877C (fr) |
| BG (1) | BG65128B1 (fr) |
| BR (1) | BR9713850A (fr) |
| CA (1) | CA2274063C (fr) |
| CZ (1) | CZ296911B6 (fr) |
| HU (1) | HUP0001698A3 (fr) |
| IL (1) | IL130180A0 (fr) |
| NZ (1) | NZ335997A (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002020495A2 (fr) * | 2000-09-06 | 2002-03-14 | Chiron Corporation | Inhibiteurs de glycogene-synthase kinase 3 |
| ATE312827T1 (de) | 2001-09-21 | 2005-12-15 | Mitsubishi Pharma Corp | 3-substituierte-4-pyrimidonderivate |
| EA007576B1 (ru) | 2001-09-21 | 2006-12-29 | Мицубиси Фарма Корпорейшн | Производные 3-замещенных 4-пиримидонов |
| TWI330183B (fr) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| EP1340759A1 (fr) * | 2002-02-28 | 2003-09-03 | Sanofi-Synthelabo | Dérivés de la 1-alkyl, 1-(hétéroalkyl)alkyl et 1-(aryl)alkyl-7-pyrimidin-4-ylimidazo[1,2-a]pyrimidin-5(1H)-one |
| KR100956052B1 (ko) | 2002-12-16 | 2010-05-06 | 미쓰비시 타나베 파마 코퍼레이션 | 3-치환-4-피리미돈 유도체 |
| TWI357408B (en) | 2003-03-26 | 2012-02-01 | Mitsubishi Tanabe Pharma Corp | 3-substituted-4-pyrimidone derivatives |
| JP5856177B2 (ja) * | 2010-10-18 | 2016-02-09 | セレニス セラピューティクス ホールディング エスアー | コレステロールモビリゼーションに有用な化合物、組成物及び方法 |
| TWI651310B (zh) * | 2014-02-20 | 2019-02-21 | 日商日本煙草產業股份有限公司 | 三化合物及其醫藥用途 |
| JP6817952B2 (ja) * | 2015-10-29 | 2021-01-20 | あすか製薬株式会社 | ピリミジン誘導体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759176A (fr) * | 1969-11-20 | 1971-05-19 | Sandoz Sa | Derives de la pyrimidine, leur preparation et medicaments contenant cesderives |
| US4438117A (en) * | 1980-09-03 | 1984-03-20 | E. I. Du Pont De Nemours And Company | 2-Substituted thio-4,5-diarylpyrimidines |
| DE3319843A1 (de) * | 1983-06-01 | 1984-12-06 | Ali-Akbar Dipl.-Chem. Dr. 4300 Mülheim Pourzal | Verfahren zur herstellung von pyrimidinen aus nitrilen und alkinen |
| US4500533A (en) * | 1983-06-22 | 1985-02-19 | Eli Lilly And Company | 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis |
| US5077142A (en) * | 1989-04-20 | 1991-12-31 | Ricoh Company, Ltd. | Electroluminescent devices |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
-
1997
- 1997-12-04 CA CA002274063A patent/CA2274063C/fr not_active Expired - Fee Related
- 1997-12-04 EP EP97954778A patent/EP0948497A2/fr not_active Withdrawn
- 1997-12-04 NZ NZ335997A patent/NZ335997A/xx unknown
- 1997-12-04 HU HU0001698A patent/HUP0001698A3/hu unknown
- 1997-12-04 CZ CZ0201599A patent/CZ296911B6/cs not_active IP Right Cessation
- 1997-12-04 BR BR9713850-9A patent/BR9713850A/pt not_active Application Discontinuation
- 1997-12-04 AU AU60120/98A patent/AU733877C/en not_active Ceased
- 1997-12-04 IL IL13018097A patent/IL130180A0/xx unknown
- 1997-12-04 AR ARP970105689A patent/AR048564A1/es not_active Application Discontinuation
- 1997-12-04 CN CN97181563A patent/CN1246858A/zh active Pending
-
1999
- 1999-06-22 BG BG103512A patent/BG65128B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1246858A (zh) | 2000-03-08 |
| AU6012098A (en) | 1998-06-29 |
| BG65128B1 (bg) | 2007-03-30 |
| HUP0001698A2 (hu) | 2001-04-28 |
| BG103512A (en) | 2000-07-31 |
| CZ9902015A3 (cs) | 1999-11-17 |
| HUP0001698A3 (en) | 2002-07-29 |
| CZ296911B6 (cs) | 2006-07-12 |
| AU733877C (en) | 2003-05-08 |
| IL130180A0 (en) | 2000-06-01 |
| AU733877B2 (en) | 2001-05-31 |
| CA2274063C (fr) | 2007-09-04 |
| EP0948497A2 (fr) | 1999-10-13 |
| BR9713850A (pt) | 2000-02-29 |
| NZ335997A (en) | 2001-08-31 |
| AR048564A1 (es) | 2006-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |