CA2263838A1 - Crystal structures of a protein tyrosine kinase - Google Patents
Crystal structures of a protein tyrosine kinase Download PDFInfo
- Publication number
- CA2263838A1 CA2263838A1 CA002263838A CA2263838A CA2263838A1 CA 2263838 A1 CA2263838 A1 CA 2263838A1 CA 002263838 A CA002263838 A CA 002263838A CA 2263838 A CA2263838 A CA 2263838A CA 2263838 A1 CA2263838 A1 CA 2263838A1
- Authority
- CA
- Canada
- Prior art keywords
- atom
- tyrosine kinase
- protein tyrosine
- crystalline form
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/701,191 US5942428A (en) | 1996-08-21 | 1996-08-21 | Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases |
US08/701,191 | 1996-08-21 | ||
US3416896P | 1996-12-19 | 1996-12-19 | |
US60/034,168 | 1996-12-19 | ||
PCT/US1997/014885 WO1998007835A2 (en) | 1996-08-21 | 1997-08-21 | Crystal structures of a protein tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2263838A1 true CA2263838A1 (en) | 1998-02-26 |
Family
ID=26710643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002263838A Abandoned CA2263838A1 (en) | 1996-08-21 | 1997-08-21 | Crystal structures of a protein tyrosine kinase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0931152A2 (ja) |
JP (1) | JP2001514484A (ja) |
AU (1) | AU733890B2 (ja) |
CA (1) | CA2263838A1 (ja) |
WO (1) | WO1998007835A2 (ja) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
SK287132B6 (sk) * | 1998-05-29 | 2009-12-07 | Sugen, Inc. | Farmaceutická kompozícia obsahujúca pyrolom substituovaný 2-indolinón, súprava obsahujúca uvedenú kompozíciu a použitie pyrolom substituovaného 2-indolinónu |
EP1006183A1 (en) | 1998-12-03 | 2000-06-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Recombinant soluble Fc receptors |
US6656696B2 (en) * | 1999-02-26 | 2003-12-02 | Cyclacel | Compositions and methods for monitoring the phosphorylation of natural binding partners |
US6972182B1 (en) * | 1999-02-26 | 2005-12-06 | Cyclacel, Ltd. | Methods and compositions using coiled binding partners |
US6670144B1 (en) * | 1999-02-26 | 2003-12-30 | Cyclacel, Ltd. | Compositions and methods for monitoring the phosphorylation of natural binding partners |
US6828106B2 (en) * | 1999-02-26 | 2004-12-07 | Cyclacel Limited | Methods and compositions using coiled binding partners |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
WO2000070030A1 (en) * | 1999-05-19 | 2000-11-23 | Amgen Inc. | Crystal of a lymphocyte kinase-ligand complex and methods of use |
WO2001016181A2 (en) * | 1999-08-30 | 2001-03-08 | New York University School Of Medicine | Crystal structures of domains of receptor protein tyrosine kinases and their ligands |
US7129072B1 (en) | 1999-08-30 | 2006-10-31 | New York University | Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
US7369946B2 (en) | 2000-03-29 | 2008-05-06 | Abbott Gmbh & Co. Kg | Method of identifying inhibitors of Tie-2 |
MXPA02009543A (es) * | 2000-03-29 | 2005-08-26 | Abbott Gmbh & Co Kg | Metodo para identificar inhibidores de tie-2. |
US6904369B1 (en) * | 2000-06-29 | 2005-06-07 | The Trustees Of Columbia University In The City Of New York | Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor |
US7736875B2 (en) | 2000-09-08 | 2010-06-15 | Prozymex A/S | Dipeptidyl peptidase I crystal structure and its uses |
US6820011B2 (en) | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
BR0313078A (pt) | 2002-08-06 | 2005-07-12 | Astrazeneca Ab | Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso do composto ou de um sal deste farmaceuticamente aceitável |
JP4915980B2 (ja) | 2002-11-15 | 2012-04-11 | エムユーエスシー ファウンデーション フォー リサーチ デベロップメント | 補体レセプター2標的化補体調節因子 |
US20040253178A1 (en) * | 2002-12-20 | 2004-12-16 | Shane Atwell | Crystals and structures of spleen tyrosine kinase SYKKD |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
WO2004078923A2 (en) * | 2003-02-28 | 2004-09-16 | Plexxikon, Inc. | Pyk2 crystal structure and uses |
US7485297B2 (en) | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
EP1856252B1 (en) * | 2005-03-08 | 2014-11-26 | Boehringer Ingelheim International GmbH | Crystallographic structure of mnk-1 and mnk-2 proteins |
WO2006108270A1 (en) | 2005-04-11 | 2006-10-19 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
PT2044111E (pt) | 2006-06-21 | 2014-11-12 | Univ Colorado Regents | Abordagem seletiva do fator h do complemento para o tratamento de doenças |
US8338464B2 (en) | 2006-11-30 | 2012-12-25 | Albert Einstein College Of Medicine Of Yeshiva University | Small molecule inhibitors of BCL6 |
AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
KR20120130748A (ko) | 2009-11-05 | 2012-12-03 | 알렉시온 캠브리지 코포레이션 | 발작성 야간 혈색소뇨증, 용혈성 빈혈, 및 혈관내 및 혈관외 용혈을 수반한 질환 상태의 치료 |
EP2569332B1 (en) | 2010-05-14 | 2019-01-09 | The Regents of the University of Colorado, A Body Corporate | Improved complement receptor 2 (cr2) targeting groups |
CA2803588A1 (en) | 2010-06-22 | 2011-12-29 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the c3d fragment of complement component 3 |
JP6158092B2 (ja) | 2010-12-16 | 2017-07-05 | アラーガン、インコーポレイテッドAllergan,Incorporated | ケモカイン受容体調節因子としての硫黄誘導体 |
US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE920318A1 (en) * | 1991-01-31 | 1992-07-29 | Univ California | Human platelet-derived growth factor receptors |
-
1997
- 1997-08-21 AU AU41603/97A patent/AU733890B2/en not_active Ceased
- 1997-08-21 CA CA002263838A patent/CA2263838A1/en not_active Abandoned
- 1997-08-21 EP EP97939534A patent/EP0931152A2/en not_active Withdrawn
- 1997-08-21 JP JP51103698A patent/JP2001514484A/ja not_active Ceased
- 1997-08-21 WO PCT/US1997/014885 patent/WO1998007835A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0931152A2 (en) | 1999-07-28 |
AU733890B2 (en) | 2001-05-31 |
AU4160397A (en) | 1998-03-06 |
JP2001514484A (ja) | 2001-09-11 |
WO1998007835A3 (en) | 1998-10-01 |
WO1998007835A2 (en) | 1998-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2263838A1 (en) | Crystal structures of a protein tyrosine kinase | |
WO1998007835A9 (en) | Crystal structures of a protein tyrosine kinase | |
US5942428A (en) | Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases | |
JP7336178B2 (ja) | 治療における使用のための新規のTNFα構造 | |
WO2003035846A2 (en) | Structure of tall-1 and its cognate receptor | |
WO2004078923A2 (en) | Pyk2 crystal structure and uses | |
WO2008068534A2 (en) | Crystal structure of a betal -adremergi c receptor and uses thereof | |
CA2460151A1 (en) | Cytokine receptor | |
CA2456236A1 (en) | Methods of screening based on the egf receptor crystal structure | |
WO2017117118A1 (en) | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases | |
WO2009055509A9 (en) | Cholesterol consensus motif of membrane proteins | |
AU6960696A (en) | Crystalline zap family proteins | |
WO2007010285A2 (en) | Crystal structure of human soluble adenylate cyclase | |
WO2007075414A2 (en) | Chemically derivatized cd4 and uses thereof | |
WO2007039761A2 (en) | Crystal structure of cd44 and its use | |
KR101421089B1 (ko) | 대장암에 특이적인 항암 활성을 갖는 신규 펩타이드, 이를 포함하는 ndrg2 결정체 및 이의 용도 | |
WO2016201566A1 (en) | Systems and methods of selecting compounds with reduced risk of cardiotoxicity using herg models | |
WO2008037688A2 (en) | Crystalline forms of pkc alpha kinase, methods of making such crystals, and uses thereof | |
WO2012097826A2 (en) | Crystal structure of a type ib p-type atpase | |
JP2005137361A (ja) | ペプチジルアルギニンデイミナーゼ4又はその変異体タンパク質の結晶、ペプチジルアルギニンデイミナーゼ4変異体タンパク質及びその複合体 | |
WO2009076621A1 (en) | High resolution structures of acidic mammalian chitinases and uses thereof | |
WO2012037150A1 (en) | Crystal structures of o-glcnac transferase and uses thereof | |
WO2003006987A9 (en) | Methods and compositions for determining enzymatic activity and specificity of methyltransferases | |
WO2006047505A2 (en) | Crystal structure of the c-fms kinase domain | |
AU5660900A (en) | Crystalline zap family proteins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |