CA2261989C - Recombinant pox virus for immunization against tumor-associated antigens - Google Patents
Recombinant pox virus for immunization against tumor-associated antigens Download PDFInfo
- Publication number
- CA2261989C CA2261989C CA002261989A CA2261989A CA2261989C CA 2261989 C CA2261989 C CA 2261989C CA 002261989 A CA002261989 A CA 002261989A CA 2261989 A CA2261989 A CA 2261989A CA 2261989 C CA2261989 C CA 2261989C
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- recombinant
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- pox virus
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24041—Use of virus, viral particle or viral elements as a vector
- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68628096A | 1996-07-25 | 1996-07-25 | |
| US08/686,280 | 1996-07-25 | ||
| PCT/US1997/012203 WO1998004727A1 (en) | 1996-07-25 | 1997-07-15 | Recombinant pox virus for immunization against tumor-associated antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2261989A1 CA2261989A1 (en) | 1998-02-05 |
| CA2261989C true CA2261989C (en) | 2008-09-30 |
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|---|---|---|---|
| CA002261989A Expired - Fee Related CA2261989C (en) | 1996-07-25 | 1997-07-15 | Recombinant pox virus for immunization against tumor-associated antigens |
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| US (1) | US7410644B2 (ref) |
| EP (2) | EP2112225A1 (ref) |
| JP (2) | JP4475683B2 (ref) |
| AU (1) | AU731860B2 (ref) |
| CA (1) | CA2261989C (ref) |
| WO (1) | WO1998004727A1 (ref) |
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| US5925362A (en) * | 1993-08-11 | 1999-07-20 | Jenner Technologies | Method to elicit an antitumor response with human prostate-specific antigen |
| US20010036928A1 (en) * | 1996-04-22 | 2001-11-01 | Chamberlain Ronald S. | Heterologous boosting immunizations |
| US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| CN1298851C (zh) * | 1998-11-18 | 2007-02-07 | 牛津生物医学（英国）有限公司 | 多肽 |
| US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
| JP4409097B2 (ja) * | 1998-12-09 | 2010-02-03 | アメリカ合衆国 | 複数の共刺激分子を発現する組換えベクターおよびその利用 |
| EP1865065A1 (en) * | 1998-12-09 | 2007-12-12 | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | A recombinant vector expressing multiple costimulatory molecules and uses thereof |
| ATE369895T1 (de) * | 2002-04-09 | 2007-09-15 | Sanofi Pasteur Ltd | Modifizierte cea nucleinsäure und expressionsvektoren |
| AU2004267117B2 (en) * | 2003-08-21 | 2011-01-20 | Virax Development Pty Ltd | Poxvirus vector encoding prostate specific antigens for treatment of prostate cancer |
| US8562970B2 (en) * | 2003-10-08 | 2013-10-22 | Sanofi Pasteur Limited | Modified CEA/B7 vector |
| WO2005046614A2 (en) * | 2003-11-12 | 2005-05-26 | Therion Biologics Corporation | System for treating and preventing breast cancer |
| US8901093B2 (en) | 2003-11-12 | 2014-12-02 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Custom vectors for treating and preventing pancreatic cancer |
| MX2011007494A (es) | 2009-01-13 | 2011-08-12 | Transgene Sa | Uso de una fraccion de la mitocondria de acidos nucleicos de saccharomyces cerevisiae para la estimulacion inmune. |
| MX2011007386A (es) | 2009-01-20 | 2011-08-03 | Transgene Sa | Icam-1 soluble como un biomarcador para la prediccion de una respuesta terapeutica. |
| WO2010108908A1 (en) | 2009-03-24 | 2010-09-30 | Transgene Sa | Biomarker for monitoring patients |
| JP5661738B2 (ja) | 2009-04-17 | 2015-01-28 | トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． | 患者をモニターするためのバイオマーカー |
| CA2767458A1 (en) | 2009-07-10 | 2011-01-13 | Bruce Acres | Biomarker for selecting patients and related methods |
| WO2012019125A2 (en) | 2010-08-06 | 2012-02-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for prostate cancer and methods for their detection |
| US9725494B2 (en) * | 2013-05-17 | 2017-08-08 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Soluble CD27 (sCD27) and the use thereof |
| CA2928199C (en) * | 2013-11-05 | 2025-06-17 | Bavarian Nordic A/S | POLYTHERAPY FOR CANCER TREATMENT USING A POXVIRUS EXPRESSING A TUMOR ANTIGEN AND AN ANTAGONIST AND/OR AGONIST OF AN IMMUNE CHECKPOINT INHIBITOR |
| CA2946606C (en) | 2014-05-13 | 2023-06-06 | Bavarian Nordic A/S | Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist of tim-3 |
| US10765710B2 (en) | 2014-07-16 | 2020-09-08 | Institut Gustave-Roussy | Combination of oncolytic virus with immune checkpoint modulators |
| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| US11753652B2 (en) | 2015-07-31 | 2023-09-12 | Bavarian Nordic A/S | Cassette encoding a FPV/brachyury fusion protein |
| EP3400009A2 (en) | 2016-01-05 | 2018-11-14 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Combination of histone deacetylase inhibitor and immunotherapy |
| WO2017129769A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for enhancing the potency of the immune checkpoint inhibitors |
| WO2017136342A1 (en) | 2016-02-02 | 2017-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells |
| EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
| EP3518964A2 (en) | 2016-09-28 | 2019-08-07 | Bavarian Nordic A/S | Compositions and methods for enhancing the stability of transgenes in poxviruses |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| EP3562946B1 (en) | 2016-12-28 | 2021-11-24 | Transgene SA | Oncolytic viruses and therapeutic molecules |
| KR102808275B1 (ko) | 2017-04-14 | 2025-05-20 | 탈락 테라퓨틱스, 인크. | 면역조절 폴리뉴클레오티드, 이의 항체 접합체, 및 이의 사용 방법 |
| US11052147B2 (en) | 2017-05-15 | 2021-07-06 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| CA3061678A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| JP7202362B2 (ja) | 2017-08-24 | 2023-01-11 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えｍｖａ及び抗体の静脈内投与を用いた、がん治療のための併用療法 |
| WO2019170820A1 (en) | 2018-03-07 | 2019-09-12 | Transgene | Parapoxvirus vectors |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| EP3847246A1 (en) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| EP3976071A1 (en) | 2019-05-29 | 2022-04-06 | Université de Tours | Toxoplasma platform for treating cancer |
| US11920136B2 (en) | 2020-02-28 | 2024-03-05 | Tallac Therapeutics, Inc. | Transglutaminase-mediated conjugation |
| WO2021180943A1 (en) | 2020-03-12 | 2021-09-16 | Bavarian Nordic A/S | Compositions improving poxvirus stability |
| WO2024038175A1 (en) | 2022-08-18 | 2024-02-22 | Transgene | Chimeric poxviruses |
| WO2026041811A1 (en) | 2024-08-23 | 2026-02-26 | Transgene | Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| DK354487A (da) * | 1986-07-11 | 1988-01-12 | Noboru Yanaihara | Oncogen-relaterede peptider |
| US5266313A (en) | 1987-02-03 | 1993-11-30 | The United States Of America As Represented By The Department Of Health And Human Services | Raccoon poxvirus as a gene expression and vaccine vector for genes of rabies virus and other organisms |
| DE10399031I1 (de) | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
| CA1340203C (en) | 1987-09-16 | 1998-12-15 | Noboru Yanagida | Recombinant apivoxvirus |
| US5093258A (en) | 1988-08-26 | 1992-03-03 | Therion Biologics Corporation | Recombinant fowlpox virus and recombination vector |
| WO1991019803A1 (en) | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Self assembled, defective, nonself-propagating viral particles |
| CA2102623C (en) * | 1991-05-06 | 2003-04-22 | Jeffrey Schlom | Recombinant virus expressing carcinoembryonic antigen and methods of use thereof |
| US5445953A (en) | 1991-08-26 | 1995-08-29 | Immuno Aktiengesellschaft | Direct molecular cloning of a modified poxvirus genome |
| US5382425A (en) | 1992-01-13 | 1995-01-17 | Syntro Corporation | Recombinant swinepox virus |
| US5374149A (en) | 1993-01-13 | 1994-12-20 | Computower Technologies, Corp. | Vertical storage conveyor with symmetrical motor drive system |
| WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
| WO1996010419A2 (en) * | 1994-10-03 | 1996-04-11 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services, Office Of Technology Transfer | Composition comprising a recombinant virus expressing an antigen and a recombinant virus expressing an immunostimulatory molecule |
| US6001349A (en) * | 1995-02-22 | 1999-12-14 | Therion Biologics Corporation | Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof |
| US6165460A (en) * | 1995-07-10 | 2000-12-26 | Therion Biologics Corporation | Generation of immune responses to prostate-specific antigen (PSA) |
-
1997
- 1997-07-15 EP EP09010415A patent/EP2112225A1/en not_active Ceased
- 1997-07-15 CA CA002261989A patent/CA2261989C/en not_active Expired - Fee Related
- 1997-07-15 JP JP50884498A patent/JP4475683B2/ja not_active Expired - Lifetime
- 1997-07-15 AU AU37268/97A patent/AU731860B2/en not_active Ceased
- 1997-07-15 WO PCT/US1997/012203 patent/WO1998004727A1/en not_active Ceased
- 1997-07-15 EP EP97934142A patent/EP0954593A1/en not_active Withdrawn
-
2002
- 2002-07-17 US US10/197,127 patent/US7410644B2/en not_active Expired - Fee Related
-
2009
- 2009-07-22 JP JP2009171254A patent/JP2009278997A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998004727A1 (en) | 1998-02-05 |
| US7410644B2 (en) | 2008-08-12 |
| JP2009278997A (ja) | 2009-12-03 |
| JP4475683B2 (ja) | 2010-06-09 |
| US20030003079A1 (en) | 2003-01-02 |
| EP2112225A1 (en) | 2009-10-28 |
| JP2000516459A (ja) | 2000-12-12 |
| AU3726897A (en) | 1998-02-20 |
| EP0954593A1 (en) | 1999-11-10 |
| AU731860B2 (en) | 2001-04-05 |
| CA2261989A1 (en) | 1998-02-05 |
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