CA2258593A1 - Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases - Google Patents
Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases Download PDFInfo
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- CA2258593A1 CA2258593A1 CA002258593A CA2258593A CA2258593A1 CA 2258593 A1 CA2258593 A1 CA 2258593A1 CA 002258593 A CA002258593 A CA 002258593A CA 2258593 A CA2258593 A CA 2258593A CA 2258593 A1 CA2258593 A1 CA 2258593A1
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- cancer
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- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Landscapes
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- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/674,481 US6040342A (en) | 1994-09-16 | 1996-07-02 | Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
| US08/674,481 | 1996-07-02 | ||
| US08/883,219 US6071923A (en) | 1994-09-16 | 1997-06-26 | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
| US08/883,219 | 1997-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2258593A1 true CA2258593A1 (en) | 1998-01-08 |
Family
ID=27101163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002258593A Abandoned CA2258593A1 (en) | 1996-07-02 | 1997-07-01 | Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0927033A1 (enExample) |
| JP (1) | JP2002514161A (enExample) |
| AU (1) | AU3588097A (enExample) |
| CA (1) | CA2258593A1 (enExample) |
| IL (1) | IL127739A0 (enExample) |
| WO (1) | WO1998000127A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6124495A (en) * | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
| US6110970A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Nitrogen-containing oxyalkylene esters and uses thereof |
| US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| HK1038882A1 (zh) * | 1998-04-15 | 2002-04-04 | 利思进药品公司 | 通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 |
| MXPA00010151A (es) * | 1998-04-17 | 2002-08-06 | Lexigen Pharm Corp | Mejoramiento de las respuestas inmunes mediadas por proteina de fusion de anticuerpo-citocina mediante la soadministracion con inhibidores de prostaglandina. |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU778611B2 (en) | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| ATE368475T1 (de) | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| US6720445B2 (en) | 2000-12-21 | 2004-04-13 | Beacon Laboratories, Inc. | Acetyloxymethyl esters and methods for using the same |
| BR0207854A (pt) | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| US8946295B2 (en) * | 2002-07-25 | 2015-02-03 | Sunny Pharmtech Inc. | Histone hyperacetylating agents for promoting wound healing and preventing scar formation |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| DK1572748T3 (da) | 2002-12-17 | 2010-08-23 | Merck Patent Gmbh | Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2 |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| ES2305886T3 (es) | 2003-12-30 | 2008-11-01 | Merck Patent Gmbh | Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo. |
| KR20060124656A (ko) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
| US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| JP4921351B2 (ja) * | 2004-03-26 | 2012-04-25 | ディーエスエム アイピー アセッツ ビー．ブイ． | レチノイドと組み合せたｈｄａｃインヒビターを含む組成物 |
| JP4937132B2 (ja) | 2004-12-09 | 2012-05-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 免疫原性の低下したｉｌ−７変種 |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CN101263121A (zh) | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
| MX2011011044A (es) | 2009-04-22 | 2011-11-04 | Merck Patent Gmbh | Proteinas de fusion de anticuerpos con sitios de enlace de receptor fc neonatal (fcrn) modificados. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677120A (en) * | 1985-07-31 | 1987-06-30 | Molecular Design International | Topical prodrugs for treatment of acne and skin diseases |
| DK498487A (da) * | 1986-10-06 | 1988-04-07 | Hoffmann La Roche | Hidtil ukendte retinoider |
| US4885311A (en) * | 1987-06-29 | 1989-12-05 | Molecular Design International | Topical transretinoids for treatment of acne and skin diseases |
| US4994491A (en) * | 1988-12-14 | 1991-02-19 | Molecular Design International | Dermal uses of trans-retinoids for the treatment of cancer |
| CA2037150C (en) * | 1990-03-27 | 1999-12-28 | Guenter Gross | Retinoids |
| US5710176A (en) * | 1994-09-16 | 1998-01-20 | Bar-Ilan University | Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
-
1997
- 1997-07-01 JP JP50440398A patent/JP2002514161A/ja active Pending
- 1997-07-01 WO PCT/US1997/011452 patent/WO1998000127A1/en not_active Ceased
- 1997-07-01 EP EP97932417A patent/EP0927033A1/en not_active Withdrawn
- 1997-07-01 AU AU35880/97A patent/AU3588097A/en not_active Abandoned
- 1997-07-01 CA CA002258593A patent/CA2258593A1/en not_active Abandoned
- 1997-07-01 IL IL12773997A patent/IL127739A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0927033A1 (en) | 1999-07-07 |
| EP0927033A4 (enExample) | 1999-07-07 |
| JP2002514161A (ja) | 2002-05-14 |
| IL127739A0 (en) | 1999-10-28 |
| AU3588097A (en) | 1998-01-21 |
| WO1998000127A1 (en) | 1998-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |