CA2251972A1 - Therapie combinatoire pour reduire les risques associes a une maladie cardiovasculaire - Google Patents

Therapie combinatoire pour reduire les risques associes a une maladie cardiovasculaire Download PDF

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Publication number
CA2251972A1
CA2251972A1 CA002251972A CA2251972A CA2251972A1 CA 2251972 A1 CA2251972 A1 CA 2251972A1 CA 002251972 A CA002251972 A CA 002251972A CA 2251972 A CA2251972 A CA 2251972A CA 2251972 A1 CA2251972 A1 CA 2251972A1
Authority
CA
Canada
Prior art keywords
hmg
inhibitor
pharmaceutically acceptable
vitamin
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002251972A
Other languages
English (en)
Inventor
Jonathan A. Tobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612082.9A external-priority patent/GB9612082D0/en
Priority claimed from GBGB9616804.2A external-priority patent/GB9616804D0/en
Application filed by Individual filed Critical Individual
Publication of CA2251972A1 publication Critical patent/CA2251972A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention présente des méthodes tant pour prévenir ou réduire le risque de contracter l'athérosclérose, que pour enrayer cette maladie ou ralentir sa progression une fois qu'elle est devenue cliniquement évidente; elles consistent à administrer une quantité thérapeutique d'un HMG-CoA RI en combinaison avec l'acide folique ou encore un de ses sels ou esters pharmacocompatibles, à une personne qui risque de contracter l'athérosclérose ou qui est déjà atteinte.
CA002251972A 1996-04-17 1997-04-14 Therapie combinatoire pour reduire les risques associes a une maladie cardiovasculaire Abandoned CA2251972A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US1568996P 1996-04-17 1996-04-17
US60/015,689 1996-04-17
GB9612082.9 1996-06-10
GBGB9612082.9A GB9612082D0 (en) 1996-06-10 1996-06-10 Combination therapy for reducing the risks associated with cardiovascular disease
US2097796P 1996-06-24 1996-06-24
US60/020,977 1996-06-24
GB9616804.2 1996-08-09
GBGB9616804.2A GB9616804D0 (en) 1996-08-09 1996-08-09 Combination therapy for reducing the risks associated with cardiovascular disease

Publications (1)

Publication Number Publication Date
CA2251972A1 true CA2251972A1 (fr) 1997-10-23

Family

ID=27451457

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002251972A Abandoned CA2251972A1 (fr) 1996-04-17 1997-04-14 Therapie combinatoire pour reduire les risques associes a une maladie cardiovasculaire

Country Status (5)

Country Link
EP (1) EP0904082A4 (fr)
JP (1) JP2000508659A (fr)
AU (1) AU732465B2 (fr)
CA (1) CA2251972A1 (fr)
WO (1) WO1997038694A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0946178A4 (fr) * 1996-09-18 2003-05-07 Merck & Co Inc Traitement combine destine a reduire les risques de maladies cardio-vasculaires
AU9454098A (en) * 1997-09-24 1999-04-12 Nova Molecular, Inc. Methods for increasing apoe levels for the treatment of neurodegenerative disease
AU1306099A (en) * 1997-12-12 1999-07-05 Warner-Lambert Company Antihyperlipidemic statin-lp(a) inhibitor combinations
US6235311B1 (en) * 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
GB2336534A (en) * 1998-04-24 1999-10-27 Alec James Coppen Anti-depressant - Folic Acid Combination
AR030414A1 (es) * 2000-04-03 2003-08-20 Astrazeneca Ab Combinacion farmaceutica que comprende un beta bloqueante y un inhibidor de hmg-coa reductasa , formulacion farmaceutica, equipo transportable de partes , uso de esta combinacion y de esta formulacion para preparar medicamentos
AU4671101A (en) * 2000-04-10 2001-10-23 Malcolm R. Law Formulation for the prevention of cardiovascular disease
GB2361185A (en) 2000-04-10 2001-10-17 Nicholas J Wald Pharmaceutical formulation for the prevention of cardiovascular disease
SE0002354D0 (sv) * 2000-06-22 2000-06-22 Astrazeneca Ab New formulation
US6916849B2 (en) 2000-10-23 2005-07-12 Sankyo Company, Limited Compositions for improving lipid content in the blood
CN1250212C (zh) * 2000-10-23 2006-04-12 三共株式会社 血中脂类改善剂组合物
CA2428204A1 (fr) 2000-11-07 2002-05-16 Sankyo Company, Limited Compositions permettant de reduire la concentration de peroxydes lipidiques
MXPA03004818A (es) * 2000-11-29 2003-09-10 Smithkline Beecham Corp Composicion conteniendo estatinas y calcio para salud cardiovascular mejorada.
US7037934B2 (en) 2000-12-14 2006-05-02 Sankyo Company, Limited Blood lipid ameliorant composition
WO2002047683A1 (fr) * 2000-12-14 2002-06-20 Sankyo Company, Limited Composition ameliorant les lipides dans le sang
WO2002047682A1 (fr) * 2000-12-14 2002-06-20 Sankyo Company, Limited Composition ameliorant les lipides sanguins
TWI284529B (en) * 2000-12-18 2007-08-01 Sankyo Co A composition for lowering triglyceride
PT1413331E (pt) * 2001-01-26 2007-12-18 Schering Corp Combinações do activador do receptor activado por proliferador do peroxisoma (ppar) fenofibrato e inibidor da absorção de esterol para indicações vasculares.
JP4611622B2 (ja) * 2002-07-11 2011-01-12 第一三共株式会社 血中脂質改善又は血中ホモシステイン低下のための医薬組成物
WO2004006919A1 (fr) * 2002-07-11 2004-01-22 Sankyo Company, Limited Composition medicale pour reduire le taux de lipides sanguins ou le taux d'homocysteine sanguine
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
JP4607436B2 (ja) * 2002-08-02 2011-01-05 第一三共株式会社 ＨＭＧ−ＣｏＡリダクターゼ阻害剤を含有する医薬組成物
WO2004012740A1 (fr) * 2002-08-02 2004-02-12 Sankyo Company, Limited Composition medicamenteuse contenant un inhibiteur de hmg-coa reductase
US20070280915A1 (en) * 2003-12-23 2007-12-06 Medicure International Inc. Combination Therapies Employing A Composition Comprising A Hmg Coa Reductase Inhibitor And A Vitamin B6 Related Compound
CA2794424C (fr) * 2004-03-29 2019-06-04 Wyeth Llc Complements nutritionnels mineraux multivitamines
EP1841436A4 (fr) * 2005-01-05 2008-02-20 Medicure Int Inc Composes et techniques de regulation des niveaux de triglyceride
AU2007299726A1 (en) * 2006-09-22 2008-03-27 Braincells, Inc. Combination comprising an HMG-COA reductase inhibitor and a second neurogenic agent for treating a nervous system disorder and increasing neurogenesis
EP2810644A1 (fr) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Formulation orale pour le traitement de maladies cardiovasculaires
JP6443935B2 (ja) * 2013-07-26 2018-12-26 学校法人 久留米大学 動脈硬化の治療または予防のためのアスピリンおよび葉酸の併用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895107A (en) * 1970-04-15 1975-07-15 Morrison L M CSA and CSC in man and mammals to inhibit atherosclerosis and the recurrence of cardiovascular incidents in atherosclerotic mammals
US5084482A (en) * 1990-04-10 1992-01-28 The Lithox Corporation Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds
DE4326698C2 (de) * 1993-08-09 1997-05-28 Puetter Medice Chem Pharm Verwendung einer Kombination aus Folsäure, Vitamin B¶6¶ und Vitamin B¶1¶¶2¶ zur Prophylaxe und Therapie von Arteriosklerose
US5631401A (en) * 1994-02-09 1997-05-20 Abbott Laboratories Inhibitors of protein farnesyltransferase and squalene synthase

Also Published As

Publication number Publication date
EP0904082A1 (fr) 1999-03-31
WO1997038694A1 (fr) 1997-10-23
EP0904082A4 (fr) 2001-09-26
JP2000508659A (ja) 2000-07-11
AU732465B2 (en) 2001-04-26
AU2666597A (en) 1997-11-07

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