CA2251558C - Complexe du facteur viii hautement purifie - Google Patents
Complexe du facteur viii hautement purifie Download PDFInfo
- Publication number
- CA2251558C CA2251558C CA002251558A CA2251558A CA2251558C CA 2251558 C CA2251558 C CA 2251558C CA 002251558 A CA002251558 A CA 002251558A CA 2251558 A CA2251558 A CA 2251558A CA 2251558 C CA2251558 C CA 2251558C
- Authority
- CA
- Canada
- Prior art keywords
- vwf
- factor viii
- preparation
- complex
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne un complexe hautement purifié ayant comme composants le factor VIII et le facteur de von Willebrand (vWF), présentant une activité spécifique d'au moins 70, de préférence de 100 à 300 E du facteur VIII/mg. L'invention concerne également une préparation pharmaceutique stable contenant ce complexe, ainsi qu'un procédé de production de ce complexe, fondé sur la chromatographie d'immunoaffinité.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATA667/96 | 1996-04-12 | ||
AT0066796A AT403765B (de) | 1996-04-12 | 1996-04-12 | Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex |
PCT/AT1997/000069 WO1997039033A1 (fr) | 1996-04-12 | 1997-04-09 | Purification du complexe du facteur viii par chromatographie d'immunoaffinite |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2251558A1 CA2251558A1 (fr) | 1997-10-23 |
CA2251558C true CA2251558C (fr) | 2005-11-22 |
Family
ID=35474793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002251558A Expired - Fee Related CA2251558C (fr) | 1996-04-12 | 1997-04-09 | Complexe du facteur viii hautement purifie |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2251558C (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT406867B (de) | 1997-02-27 | 2000-10-25 | Immuno Ag | Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex |
AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
-
1997
- 1997-04-09 CA CA002251558A patent/CA2251558C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2251558A1 (fr) | 1997-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI106721B (fi) | Menetelmä ihmisen standardisoidun, korkean puhtauden omaavan von Willebrand -tekijän konsentraatin valmistamiseksi | |
US7498146B2 (en) | Stable factor VIII/von willebrand factor complex | |
CA2201714C (fr) | Procede pour l'extraction du facteur willebrand a haute purete | |
JP2009161547A (ja) | 高度に精製された第viii因子コンプレックス | |
JP3110292B2 (ja) | フォンウィルブランド因子の高分子および低分子フラクション | |
US6465624B1 (en) | Purification of von-Willebrand factor by cation exchanger chromatography | |
US6579723B1 (en) | Method of recovering highly purified vWF or factor VIII/vWF-complex | |
US6005077A (en) | Use of von willebrand factor and pharmaceutical formulation | |
IE66836B1 (en) | A method for isolating biologically active compounds | |
US5484890A (en) | Antihemophilic factor stabilization | |
US4774323A (en) | Purification of von Willebrand Factor solutions using gel permeation chromatography | |
Josic et al. | Purification of factor VIII and von Willebrand factor from human plasma by anion-exchange chromatography | |
US5710254A (en) | Purification of von Willebrand factor by affinity chromatography | |
CA2251558C (fr) | Complexe du facteur viii hautement purifie | |
US7939643B2 (en) | Production of a von Willebrand factor preparation using hydroxylapatite | |
US6414125B1 (en) | Method of chromatographically purifying or fractionating, respectively, von Willebrand factor from a VWF-containing starting material | |
Ganz et al. | Definition of the affinity of binding between human von Willebrand factor and coagulation factor VIII | |
US10889630B2 (en) | Method of separating Factor VIII from blood products | |
Marcus et al. | Purification and properties of porcine platelet aggregating factor | |
Martin et al. | Potentiation of wheat germ agglutinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic fragment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20130409 |