CA2250361A1 - Peptides de la glycoproteine d'oligodendrocyte de myeline et leurs utilisations - Google Patents
Peptides de la glycoproteine d'oligodendrocyte de myeline et leurs utilisations Download PDFInfo
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- CA2250361A1 CA2250361A1 CA002250361A CA2250361A CA2250361A1 CA 2250361 A1 CA2250361 A1 CA 2250361A1 CA 002250361 A CA002250361 A CA 002250361A CA 2250361 A CA2250361 A CA 2250361A CA 2250361 A1 CA2250361 A1 CA 2250361A1
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- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
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- 230000001052 transient effect Effects 0.000 description 1
- 229940108519 trasylol Drugs 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
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- 239000003981 vehicle Substances 0.000 description 1
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- 230000003442 weekly effect Effects 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Rehabilitation Therapy (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des peptides de la glycoprotéine d'oligodendrocyte de myéline humaine (MOG), auto-antigène lié aux maladies auto-immunes démyélinissantes. La présente invention concerne également certaines compositions incluant des peptides MOG ou des mélanges de peptides MOG et de peptides du peptide MBP. Enfin, la présente invention concerne aussi certaines compositions thérapeutiques servant au diagnostic et au traitement de certaines maladies auto-immunes ainsi que des méthodes de traitement de la sclérose en plaques au moyen desdites compositions thérapeutiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62340696A | 1996-03-28 | 1996-03-28 | |
US08/623,406 | 1996-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2250361A1 true CA2250361A1 (fr) | 1997-10-02 |
Family
ID=24497970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002250361A Abandoned CA2250361A1 (fr) | 1996-03-28 | 1996-05-01 | Peptides de la glycoproteine d'oligodendrocyte de myeline et leurs utilisations |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0922057A1 (fr) |
AU (1) | AU5671196A (fr) |
CA (1) | CA2250361A1 (fr) |
WO (1) | WO1997035879A1 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251396B1 (en) | 1994-11-18 | 2001-06-26 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
US6379670B1 (en) | 1994-11-18 | 2002-04-30 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
WO1998033912A1 (fr) * | 1997-01-30 | 1998-08-06 | Human Genome Sciences, Inc. | PROTEINE SEMBLABLE A LA GLYCOPROTEINE D'OLIGODENDROCYTE DE MYELINE (MOGp) ET PROCEDES D'UTILISATION |
SE9703287D0 (sv) * | 1997-09-11 | 1997-09-11 | Astra Ab | Peptides |
US20030108528A1 (en) * | 1998-05-19 | 2003-06-12 | Michal Eisenbach-Schwartz | Activated t-cells, nervous system-specific antigens and their uses |
US20020072493A1 (en) | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
EP1080110A2 (fr) * | 1998-05-19 | 2001-03-07 | Yeda Research And Development Co. Ltd. | Lymphocytes t actives, antigenes specifiques du systeme nerveux et leur utilisation |
US6333033B1 (en) * | 1998-08-26 | 2001-12-25 | The Regents Of The University Of California | Autoantibody inhibitors |
ITFI20010114A1 (it) * | 2001-06-22 | 2002-12-22 | Univ Firenze | Glicopeptidi,loro preparazione e loro uso nella diagnosi o nel trattamento terapeutico della sclerosi multipla |
EP2363710B1 (fr) * | 2002-08-08 | 2015-07-01 | Baylor College Of Medicine | Isolement et identification des t-cellules |
EP2328908A4 (fr) * | 2008-08-28 | 2012-11-28 | Univ New York State Res Found | Traitement des amyloïdoses au moyen de protéines basiques de myéline ou de fragments desdites |
WO2012045324A1 (fr) * | 2010-10-07 | 2012-04-12 | Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh | Procédé de détection d'une maladie de parkinson et système de test |
WO2013020914A1 (fr) * | 2011-08-10 | 2013-02-14 | Celares Gmbh | Peptides peg-conjugués |
GB201300684D0 (en) * | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
GB201300683D0 (en) * | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960705038A (ko) * | 1993-09-03 | 1996-10-09 | 스테시 엘. 채닝 | 자기 면역 질환에 관련된 프로토콜에서 미엘린 올리고덴드로시트 당 단백질 및 그의 펩타이드 부분들의 용도(users of myelin oligodendrocyte glycoprotein and peptide portions thereof in protocols related to autoimmune desease) |
WO1995007096A1 (fr) * | 1993-09-06 | 1995-03-16 | La Trobe University | Traitement de maladies auto-immunes |
CA2189990A1 (fr) * | 1994-05-10 | 1995-11-16 | Di-Hwei Hsu | Compositions et traitement de la sclerose en plaques |
-
1996
- 1996-05-01 WO PCT/US1996/006072 patent/WO1997035879A1/fr not_active Application Discontinuation
- 1996-05-01 CA CA002250361A patent/CA2250361A1/fr not_active Abandoned
- 1996-05-01 EP EP96913884A patent/EP0922057A1/fr not_active Withdrawn
- 1996-05-01 AU AU56711/96A patent/AU5671196A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU5671196A (en) | 1997-10-17 |
WO1997035879A1 (fr) | 1997-10-02 |
EP0922057A1 (fr) | 1999-06-16 |
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