CA2250129A1 - Proteine de fixation de la boite tata du candida albicans, ac ide nucleique la codant et epreuves de selection afferentes - Google Patents

Proteine de fixation de la boite tata du candida albicans, ac ide nucleique la codant et epreuves de selection afferentes Download PDF

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Publication number
CA2250129A1
CA2250129A1 CA002250129A CA2250129A CA2250129A1 CA 2250129 A1 CA2250129 A1 CA 2250129A1 CA 002250129 A CA002250129 A CA 002250129A CA 2250129 A CA2250129 A CA 2250129A CA 2250129 A1 CA2250129 A1 CA 2250129A1
Authority
CA
Canada
Prior art keywords
candida albicans
tbp
inhibitor
complex
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002250129A
Other languages
English (en)
Inventor
Stephen Buratowski
Robin Buratowski
C. Richard Wobbe
John Bradley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Anadys Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2250129A1 publication Critical patent/CA2250129A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un nouveau facteur de transcription issu du Candida albicans, la protéine de fixation de la boîte TATA (TBP), une séquence nucléotidique codant la protéine de fixation de la boîte TATA (TBP) ainsi que des techniques permettant de mener des épreuves de sélection pour des inhibiteurs de la croissance du Candida albicans par ciblage de la TBP.
CA002250129A 1996-04-01 1997-03-31 Proteine de fixation de la boite tata du candida albicans, ac ide nucleique la codant et epreuves de selection afferentes Abandoned CA2250129A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62630996A 1996-04-01 1996-04-01
US08/626,309 1996-04-01

Publications (1)

Publication Number Publication Date
CA2250129A1 true CA2250129A1 (fr) 1997-10-09

Family

ID=24509861

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002250129A Abandoned CA2250129A1 (fr) 1996-04-01 1997-03-31 Proteine de fixation de la boite tata du candida albicans, ac ide nucleique la codant et epreuves de selection afferentes

Country Status (4)

Country Link
EP (1) EP0904289A4 (fr)
JP (1) JP2001503603A (fr)
CA (1) CA2250129A1 (fr)
WO (1) WO1997036925A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759732B2 (en) * 1998-04-24 2003-04-17 Aventis Pharma S.A. Method for screening antimycotic substances using essential genes from S. cerevisiae
GB9817796D0 (en) * 1998-08-14 1998-10-14 Janssen Pharmaceutica Nv Drug targets in candida albicans
EP0999284A1 (fr) * 1998-09-11 2000-05-10 Hoechst Marion Roussel Procédé de triage pour des substances antimycotiques utilisant des gènes dérivant de C.albicans, et les gènes eux-mêmes
WO2000034481A2 (fr) * 1998-12-04 2000-06-15 Janssen Pharmaceutica N.V. CIBLES MEDICAMENTEUSES DANS LES $i(CANDIDA ALBICANS)
AU2392300A (en) * 1998-12-31 2000-07-31 Millennium Pharmaceuticals, Inc. Use of essential (saccharomyces) genes and polypeptides
AU2748400A (en) 1999-02-04 2000-08-25 Anadys Pharmaceuticals, Inc. (candida albicans) srb-7
US8158340B2 (en) 2005-12-28 2012-04-17 Corning Incorporated Methods for detecting conformational changes in bioentities

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU682340B2 (en) * 1993-01-28 1997-10-02 Regents Of The University Of California, The TATA-binding protein associated factors, nucleic acids encoding TAFs, and methods of use
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening

Also Published As

Publication number Publication date
EP0904289A4 (fr) 2001-12-12
JP2001503603A (ja) 2001-03-21
WO1997036925A1 (fr) 1997-10-09
EP0904289A1 (fr) 1999-03-31

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FZDE Dead