CA2247192A1 - Process for determining the phototoxicity and/or photosensitivity of substances or mixtures thereof, and use thereof - Google Patents
Process for determining the phototoxicity and/or photosensitivity of substances or mixtures thereof, and use thereof Download PDFInfo
- Publication number
- CA2247192A1 CA2247192A1 CA002247192A CA2247192A CA2247192A1 CA 2247192 A1 CA2247192 A1 CA 2247192A1 CA 002247192 A CA002247192 A CA 002247192A CA 2247192 A CA2247192 A CA 2247192A CA 2247192 A1 CA2247192 A1 CA 2247192A1
- Authority
- CA
- Canada
- Prior art keywords
- embryo
- radiation
- process according
- substance
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 title claims abstract description 59
- 238000000034 method Methods 0.000 title claims abstract description 27
- 230000008569 process Effects 0.000 title claims abstract description 23
- 206010034972 Photosensitivity reaction Diseases 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 208000007578 phototoxic dermatitis Diseases 0.000 title claims abstract description 11
- 231100000018 phototoxicity Toxicity 0.000 title claims abstract description 11
- 230000036211 photosensitivity Effects 0.000 title claims abstract description 9
- 210000001161 mammalian embryo Anatomy 0.000 claims abstract description 27
- 230000007170 pathology Effects 0.000 claims abstract description 9
- 210000004027 cell Anatomy 0.000 claims abstract description 8
- 238000004113 cell culture Methods 0.000 claims abstract description 7
- 210000004927 skin cell Anatomy 0.000 claims abstract description 7
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims abstract description 6
- 238000011156 evaluation Methods 0.000 claims abstract description 6
- 210000004379 membrane Anatomy 0.000 claims description 41
- 239000012528 membrane Substances 0.000 claims description 41
- 230000005855 radiation Effects 0.000 claims description 34
- 238000002845 discoloration Methods 0.000 claims description 33
- 210000001519 tissue Anatomy 0.000 claims description 21
- 235000013601 eggs Nutrition 0.000 claims description 19
- 210000002257 embryonic structure Anatomy 0.000 claims description 13
- 102000002322 Egg Proteins Human genes 0.000 claims description 12
- 108010000912 Egg Proteins Proteins 0.000 claims description 12
- 241000271566 Aves Species 0.000 claims description 9
- 238000011534 incubation Methods 0.000 claims description 9
- 241000287828 Gallus gallus Species 0.000 claims description 8
- 235000013330 chicken meat Nutrition 0.000 claims description 8
- 230000034994 death Effects 0.000 claims description 8
- 231100000517 death Toxicity 0.000 claims description 8
- 210000002969 egg yolk Anatomy 0.000 claims description 7
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims description 6
- 210000003278 egg shell Anatomy 0.000 claims description 6
- 210000000969 egg white Anatomy 0.000 claims description 6
- 235000014103 egg white Nutrition 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 3
- 241000272496 Galliformes Species 0.000 claims description 2
- 210000003711 chorioallantoic membrane Anatomy 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000007045 gastrulation Effects 0.000 claims description 2
- 239000004009 herbicide Substances 0.000 claims description 2
- 239000002917 insecticide Substances 0.000 claims description 2
- 239000011814 protection agent Substances 0.000 claims description 2
- 230000005670 electromagnetic radiation Effects 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 description 29
- 239000002504 physiological saline solution Substances 0.000 description 23
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 17
- 231100000760 phototoxic Toxicity 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 12
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 10
- 210000001325 yolk sac Anatomy 0.000 description 9
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 7
- 229960003405 ciprofloxacin Drugs 0.000 description 7
- 229960003910 promethazine Drugs 0.000 description 6
- BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 description 5
- 229960004469 methoxsalen Drugs 0.000 description 5
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 description 5
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical compound CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 241000271567 Struthioniformes Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229960003569 hematoporphyrin Drugs 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 231100000028 nontoxic concentration Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 241000272194 Ciconiiformes Species 0.000 description 2
- 241000272201 Columbiformes Species 0.000 description 2
- 241000286209 Phasianidae Species 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000004660 morphological change Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- 235000009434 Actinidia chinensis Nutrition 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 241000272808 Anser Species 0.000 description 1
- 241000272878 Apodiformes Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000579185 Bucerotidae Species 0.000 description 1
- 241000229077 Caprimulgus Species 0.000 description 1
- 241000272161 Charadriiformes Species 0.000 description 1
- 241000579115 Coliidae Species 0.000 description 1
- 241000272177 Cuculiformes Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 231100000635 Draize test Toxicity 0.000 description 1
- 241000271559 Dromaiidae Species 0.000 description 1
- 241000288140 Gruiformes Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241000532093 Jacanidae Species 0.000 description 1
- 238000012313 Kruskal-Wallis test Methods 0.000 description 1
- 241000092193 Merops apiaster Species 0.000 description 1
- 241000566632 Musophagidae Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000531763 Otididae Species 0.000 description 1
- 241000287502 Phoenicopteriformes Species 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 241000287509 Piciformes Species 0.000 description 1
- 241001466904 Plegadis Species 0.000 description 1
- 241001415846 Procellariidae Species 0.000 description 1
- 241000598039 Promethes Species 0.000 description 1
- 241000287530 Psittaciformes Species 0.000 description 1
- 241000566111 Pterocles Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241001415849 Strigiformes Species 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 206010043275 Teratogenicity Diseases 0.000 description 1
- 241000566628 Trogoniformes Species 0.000 description 1
- 241000579101 Upupidae Species 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 238000001720 action spectrum Methods 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940088516 cipro Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000010454 developmental mechanism Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- -1 for instance Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000002363 herbicidal effect Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 210000000998 shell membrane Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000211 teratogenicity Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000723 toxicological property Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Cosmetics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19606207A DE19606207A1 (de) | 1996-02-21 | 1996-02-21 | Verfahren zur Bestimmung der Phototoxizität und/oder Photosensibilität von Stoffen oder Stoffgemischen sowie dessen Verwendung |
| DE19606207.1 | 1996-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2247192A1 true CA2247192A1 (en) | 1997-08-28 |
Family
ID=7785861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002247192A Abandoned CA2247192A1 (en) | 1996-02-21 | 1997-02-05 | Process for determining the phototoxicity and/or photosensitivity of substances or mixtures thereof, and use thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6171858B1 (en18) |
| EP (1) | EP0883808B1 (en18) |
| AT (1) | ATE192234T1 (en18) |
| AU (1) | AU1721797A (en18) |
| CA (1) | CA2247192A1 (en18) |
| DE (2) | DE19606207A1 (en18) |
| WO (1) | WO1997031266A1 (en18) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01005745A (es) * | 1998-12-09 | 2003-07-14 | Vistagen Inc | Tipificacion de la toxicidad utilizando cuerpos embrioides. |
| KR100865664B1 (ko) | 2000-06-14 | 2008-10-29 | 비스타겐 인코포레이티드 | 간 줄기 세포를 사용하는 독성 타이핑 |
| JP2007209219A (ja) * | 2006-02-07 | 2007-08-23 | Olympus Corp | 生体試料観察計測システムおよび生体試料観察計測方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS191501B1 (en) * | 1976-04-02 | 1979-07-31 | Richard Jelinek | Method of testing the embryotoxicity on the chicken embryo |
| DE3038255A1 (de) * | 1980-10-10 | 1982-05-19 | Wolfgang Prof. 7500 Karlsruhe Mehlhardt | Verfahren und vorrichtung zur pruefung von biologischen wirkungen physikalischer und/oder chemischer agenzien |
| US4613574A (en) * | 1984-05-04 | 1986-09-23 | Preventive Diagnostics Corporation | In vitro test for ocular toxic properties |
| DD256760B5 (de) * | 1986-12-24 | 1995-11-30 | Chemie Ag | Verfahren zur Pruefung der dermalen Toxizitaet von Substanzen oder Substanzgemischen und zur Selektion hautvertraeglicher Wirkstoffe |
| DE3939411A1 (de) * | 1989-11-29 | 1991-06-06 | Popp Fritz Albert | Verfahren zur pruefung der qualitaet und der qualitaetsaenderungen von biologischen systemen und mit ihnen wechselwirkenden organisch-chemischen verbindungen mittels messung der ultraschwachen photonenemission |
| EP0497399A1 (en) * | 1991-01-28 | 1992-08-05 | The Procter & Gamble Company | Process for evaluating skin irritancy |
| AU2230992A (en) * | 1991-07-06 | 1993-02-11 | University Of Leicester | Bioassay method |
| JPH08501875A (ja) * | 1992-07-27 | 1996-02-27 | インビトロ インターナショナル | 皮膚有害性のインビトロテスト |
| DE4308520A1 (de) * | 1993-03-17 | 1994-09-22 | Popp Fritz Albert Dr | Verfahren zum Unterscheiden von homozygoten, heterozygoten und normalen Zellen eines Organismus |
| US5405369A (en) * | 1994-01-25 | 1995-04-11 | Medical College Of Ohio | Photochemical ablation of gastro-intestinal tissue for augmentation of an organ |
| DE4404977C2 (de) * | 1994-02-17 | 1996-02-22 | New Standard Gmbh | Gemisch zur Feststellung der Hautverträglichkeit von chemischen Verbindungen |
-
1996
- 1996-02-21 DE DE19606207A patent/DE19606207A1/de not_active Withdrawn
-
1997
- 1997-02-05 WO PCT/EP1997/000508 patent/WO1997031266A1/de active IP Right Grant
- 1997-02-05 US US09/117,797 patent/US6171858B1/en not_active Expired - Fee Related
- 1997-02-05 EP EP97904379A patent/EP0883808B1/de not_active Expired - Lifetime
- 1997-02-05 DE DE59701514T patent/DE59701514D1/de not_active Expired - Fee Related
- 1997-02-05 AT AT97904379T patent/ATE192234T1/de not_active IP Right Cessation
- 1997-02-05 CA CA002247192A patent/CA2247192A1/en not_active Abandoned
- 1997-02-05 AU AU17217/97A patent/AU1721797A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6171858B1 (en) | 2001-01-09 |
| ATE192234T1 (de) | 2000-05-15 |
| DE59701514D1 (de) | 2000-05-31 |
| AU1721797A (en) | 1997-09-10 |
| WO1997031266A1 (de) | 1997-08-28 |
| EP0883808A1 (de) | 1998-12-16 |
| EP0883808B1 (de) | 2000-04-26 |
| DE19606207A1 (de) | 1997-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |