CA2237956A1 - 2'-[[4'-halo-[1,1'-biphenyl]-4-yl]methyl]-5'-methyl-spiro[cyclopentane-1,7'(8'h)-[3h]imidazo[2,1-b]purin]-4'(5'h)-ones - Google Patents

2'-[[4'-halo-[1,1'-biphenyl]-4-yl]methyl]-5'-methyl-spiro[cyclopentane-1,7'(8'h)-[3h]imidazo[2,1-b]purin]-4'(5'h)-ones Download PDF

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Publication number
CA2237956A1
CA2237956A1 CA002237956A CA2237956A CA2237956A1 CA 2237956 A1 CA2237956 A1 CA 2237956A1 CA 002237956 A CA002237956 A CA 002237956A CA 2237956 A CA2237956 A CA 2237956A CA 2237956 A1 CA2237956 A1 CA 2237956A1
Authority
CA
Canada
Prior art keywords
methyl
compound
imidazo
spiro
purin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002237956A
Other languages
English (en)
French (fr)
Inventor
Brian A. Mckittrick
Deen Tulshian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2237956A1 publication Critical patent/CA2237956A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002237956A 1995-11-28 1996-11-26 2'-[[4'-halo-[1,1'-biphenyl]-4-yl]methyl]-5'-methyl-spiro[cyclopentane-1,7'(8'h)-[3h]imidazo[2,1-b]purin]-4'(5'h)-ones Abandoned CA2237956A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56371795A 1995-11-28 1995-11-28
US08/563,717 1995-11-28

Publications (1)

Publication Number Publication Date
CA2237956A1 true CA2237956A1 (en) 1997-06-05

Family

ID=24251614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002237956A Abandoned CA2237956A1 (en) 1995-11-28 1996-11-26 2'-[[4'-halo-[1,1'-biphenyl]-4-yl]methyl]-5'-methyl-spiro[cyclopentane-1,7'(8'h)-[3h]imidazo[2,1-b]purin]-4'(5'h)-ones

Country Status (8)

Country Link
EP (1) EP0863902A1 (es)
JP (1) JP2000501095A (es)
AR (1) AR004752A1 (es)
AU (1) AU1055597A (es)
CA (1) CA2237956A1 (es)
CO (1) CO4480029A1 (es)
WO (1) WO1997019947A1 (es)
ZA (1) ZA969888B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326379B1 (en) 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
DE50008549D1 (de) 1999-12-24 2004-12-09 Bayer Healthcare Ag Triazolotriazinone und ihre verwendung
EP1252165A1 (de) 1999-12-24 2002-10-30 Bayer Aktiengesellschaft Isoxazolopyrimidinone und ihre verwendung
US6803365B2 (en) 1999-12-24 2004-10-12 Bayer Aktlengesellschaft Imidazo[1,3,5]triazinones and the use thereof
CN110337437B (zh) 2016-12-28 2023-02-03 达特神经科学有限公司 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物
EP3717488B1 (en) 2017-11-27 2021-09-29 Dart NeuroScience, LLC Substituted furanopyrimidine compounds as pde1 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98559A0 (en) * 1990-06-21 1992-07-15 Schering Corp Polycyclic guanine derivatives
WO1994019351A1 (en) * 1993-02-26 1994-09-01 Schering Corporation 2-benzyl-polycyclic guanine derivatives and process for preparing them

Also Published As

Publication number Publication date
MX9804198A (es) 1998-10-31
WO1997019947A1 (en) 1997-06-05
AU1055597A (en) 1997-06-19
EP0863902A1 (en) 1998-09-16
AR004752A1 (es) 1999-03-10
JP2000501095A (ja) 2000-02-02
ZA969888B (en) 1997-05-26
CO4480029A1 (es) 1997-07-09

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