CA2232601A1 - Proteines recombinees ayant de multiples liaisons disulfure et conjugues a substitution thiol de ces proteines - Google Patents
Proteines recombinees ayant de multiples liaisons disulfure et conjugues a substitution thiol de ces proteines Download PDFInfo
- Publication number
- CA2232601A1 CA2232601A1 CA 2232601 CA2232601A CA2232601A1 CA 2232601 A1 CA2232601 A1 CA 2232601A1 CA 2232601 CA2232601 CA 2232601 CA 2232601 A CA2232601 A CA 2232601A CA 2232601 A1 CA2232601 A1 CA 2232601A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- group
- agent
- immunoconjugate
- emitters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1069—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from blood cells, e.g. the cancer being a myeloma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des protéines liant des antigènes recombinés, lesquelles possèdent de multiples liaisons disulfure et sont utiles dans la préparation de conjugués immunologiques. Cette invention concerne en particulier des anticorps recombinés comportant une région charnière IgG¿3?, mais dans lesquels il manque un domaine constant CH2. Ces anticorps mutés sont utilisés afin de lier un agent diagnostique ou thérapeutique par l'intermédiaire d'une ou de plusieurs liaisons disulfure réduites situées dans la région charnière des anticorps. Cette invention concerne également l'utilisation de tels conjugués immunologiques en matière de diagnostic et de thérapie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US416995P | 1995-09-22 | 1995-09-22 | |
US60/004,169 | 1995-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2232601A1 true CA2232601A1 (fr) | 1997-03-27 |
Family
ID=21709517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2232601 Abandoned CA2232601A1 (fr) | 1995-09-22 | 1996-09-20 | Proteines recombinees ayant de multiples liaisons disulfure et conjugues a substitution thiol de ces proteines |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0861440A1 (fr) |
JP (1) | JPH11514223A (fr) |
AU (1) | AU702975B2 (fr) |
CA (1) | CA2232601A1 (fr) |
WO (1) | WO1997011370A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
JP2002534119A (ja) * | 1999-01-14 | 2002-10-15 | ボルダー バイオテクノロジー, インコーポレイテッド | 自由システイン残基を有するタンパク質の生産方法 |
US7319139B2 (en) | 2001-01-29 | 2008-01-15 | Biogen Idec, Inc. | TAG-72 specific CH2 domain deleted antibodies |
US7700097B2 (en) * | 2003-06-27 | 2010-04-20 | Biogen Idec Ma Inc. | Purification and preferential synthesis of binding molecules |
JP4691650B2 (ja) * | 2004-03-04 | 2011-06-01 | 国立大学法人広島大学 | ニワトリ型モノクローナル抗体の生産方法、および当該生産方法によって生産されるニワトリ型モノクローナル抗体 |
WO2006074399A2 (fr) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Molecules de liaison multispecifiques comprenant des peptides de connexion |
US20230122067A1 (en) * | 2020-03-26 | 2023-04-20 | Denka Company Limited | REAGENT COMPRISING ANTIBODY FROM WHICH PART OF Fc REGION IS DELETED |
EP4279502A1 (fr) * | 2021-01-18 | 2023-11-22 | Ajinomoto Co., Inc. | Composé ou son sel, et anticorps ainsi obtenu |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
-
1996
- 1996-09-20 CA CA 2232601 patent/CA2232601A1/fr not_active Abandoned
- 1996-09-20 AU AU71604/96A patent/AU702975B2/en not_active Ceased
- 1996-09-20 WO PCT/US1996/014832 patent/WO1997011370A1/fr not_active Application Discontinuation
- 1996-09-20 EP EP96933032A patent/EP0861440A1/fr not_active Withdrawn
- 1996-09-20 JP JP9512815A patent/JPH11514223A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1997011370A1 (fr) | 1997-03-27 |
AU702975B2 (en) | 1999-03-11 |
EP0861440A1 (fr) | 1998-09-02 |
JPH11514223A (ja) | 1999-12-07 |
AU7160496A (en) | 1997-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |