CA2229595A1 - Method for treatment of cancer and infectious diseases and compositions useful in same - Google Patents
Method for treatment of cancer and infectious diseases and compositions useful in same Download PDFInfo
- Publication number
- CA2229595A1 CA2229595A1 CA002229595A CA2229595A CA2229595A1 CA 2229595 A1 CA2229595 A1 CA 2229595A1 CA 002229595 A CA002229595 A CA 002229595A CA 2229595 A CA2229595 A CA 2229595A CA 2229595 A1 CA2229595 A1 CA 2229595A1
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- cells
- heat shock
- shock protein
- subject
- antigen
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Classifications
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K2039/53—DNA (RNA) vaccination
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
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- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/625—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier binding through the biotin-streptavidin system or similar
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Organic Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
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- Virology (AREA)
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- Biophysics (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
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- Communicable Diseases (AREA)
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- Zoology (AREA)
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- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US249095P | 1995-08-18 | 1995-08-18 | |
| US247995P | 1995-08-18 | 1995-08-18 | |
| US60/002,490 | 1995-08-18 | ||
| US60/002,479 | 1995-08-18 |
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| CA2229595A1 true CA2229595A1 (en) | 1997-02-27 |
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| CA002229595A Abandoned CA2229595A1 (en) | 1995-08-18 | 1996-08-16 | Method for treatment of cancer and infectious diseases and compositions useful in same |
| CA002229543A Abandoned CA2229543A1 (en) | 1995-08-18 | 1996-08-16 | Heat shock protein-based vaccines and immunotherapies |
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| CA002229543A Abandoned CA2229543A1 (en) | 1995-08-18 | 1996-08-16 | Heat shock protein-based vaccines and immunotherapies |
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| HU (1) | HUP9802819A2 (show.php) |
| IL (2) | IL123219A0 (show.php) |
| WO (3) | WO1997006685A1 (show.php) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1994029459A1 (en) | 1993-06-04 | 1994-12-22 | Whitehead Institute For Biomedical Research | Stress proteins and uses therefor |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US6331299B1 (en) | 1995-08-18 | 2001-12-18 | Sloan-Kettering Institute For Cancer Research | Method for treatment of cancer and infectious disease and compositions useful in same |
| US6719974B1 (en) | 1995-08-18 | 2004-04-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6773707B1 (en) | 1995-08-18 | 2004-08-10 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| EP0851764A4 (en) | 1995-08-18 | 2002-08-07 | Sloan Kettering Inst Cancer | VACCINE BASED ON HEAT SHOCK PROTEINS AND IMMUNOTHERAPIES |
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US5837251A (en) * | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
| US5935576A (en) * | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US6130087A (en) * | 1996-10-07 | 2000-10-10 | Fordham University | Methods for generating cytotoxic T cells in vitro |
| WO1998023735A1 (en) * | 1996-11-26 | 1998-06-04 | Stressgen Biotechnologies Corp. | Immune responses using compositions containing stress proteins |
| US7157089B1 (en) | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| US5830464A (en) | 1997-02-07 | 1998-11-03 | Fordham University | Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy |
| US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| WO1998035705A1 (en) * | 1997-02-18 | 1998-08-20 | Whitehead Institute For Biomedical Research | Use of heat shock proteins to deliver moieties into cells |
| BE1011033A6 (fr) * | 1997-03-05 | 1999-04-06 | Univ Bruxelles | Composition pharmaceutique et/ou alimentaire pour le traitement de pathologies liees a un rejet de greffe, une reaction allergique ou auto-immune ou du cancer. |
| US6709672B2 (en) | 1997-03-05 | 2004-03-23 | Biotech Tools S.A. | Pharmaceutical or food composition for treating pathologies associated with graft rejection or an allergic or autoimmune reaction |
| DK1336621T3 (da) * | 1997-08-05 | 2006-07-31 | Stressgen Biotechnologies Corp | Immunsvar mod HPV-antigener fremkaldt af sammensætninger, som omfatter et HPV-antigen og et stressprotein eller en ekspressionsvektor i stand til at eksprimere disse proteiner |
| AU2005201826B2 (en) * | 1997-08-05 | 2008-01-17 | Nventa Biopharmaceuticals Corporation | Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins |
| AU779770B2 (en) * | 1997-08-05 | 2005-02-10 | Nventa Biopharmaceuticals Corporation | Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins |
| ATE231917T1 (de) | 1997-08-05 | 2003-02-15 | Stressgen Biotechnologies Corp | Immunresponse gegen hpv antigene erregt von zusammensetzungen die ein hpv antigen und ein stressprotein enthalten oder einen expressionsvektor fähig zur expression dieser proteine |
| WO1999022761A1 (en) * | 1997-10-31 | 1999-05-14 | Sloan-Kettering Institute For Cancer Research | Conjugate heat shock protein-binding peptides |
| AU1045199A (en) * | 1997-11-05 | 1999-05-24 | Isis Innovation Limited | Cancer gene |
| US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| EP1829551B1 (en) * | 1998-02-20 | 2010-09-29 | University of Miami | Modified heat shock protein-antigenic peptide complex |
| AU5204199A (en) * | 1998-06-12 | 1999-12-30 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for modulating proteolytic degradation of intracellulartargets |
| US6160088A (en) * | 1998-07-29 | 2000-12-12 | Sloan-Kettering Institute For Cancer | KDEL receptor inhibitors |
| US6451316B1 (en) | 1998-10-05 | 2002-09-17 | University Of Conneticut Health Center | Methods for generating antigen-reactive T cells in vitro |
| US6497880B1 (en) | 1998-12-08 | 2002-12-24 | Stressgen Biotechnologies Corporation | Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus |
| CN1367875A (zh) | 1999-07-08 | 2002-09-04 | 斯特思吉生物技术公司 | 活体外th1一样反应的诱导方法 |
| GB9919733D0 (en) * | 1999-08-19 | 1999-10-20 | Colaco Camilo | Vaccines against intracellular pathogens |
| AUPQ233799A0 (en) | 1999-08-19 | 1999-09-09 | Minister For Agriculture, Minister For Land And Water Conservation For And On Behalf Of The State Of New South Wales | Recombinant sub-unit vaccine |
| US7378096B2 (en) | 1999-09-30 | 2008-05-27 | Health Research, Inc. | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| EP1216055A2 (en) | 1999-09-30 | 2002-06-26 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
| US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
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| GB9930443D0 (en) | 1999-12-22 | 2000-02-16 | King S College London | Novel use of heat shock proteins |
| DE60042704D1 (de) | 2000-01-14 | 2009-09-17 | Whitehead Biomedical Inst | Induktion zytotoxischer lymphozyten durch hitzeschockprotein-fusionsproteine hängt von der atp-bindungsdomäne in hsp ab und is cd4+ unabhängig |
| ATE375169T1 (de) * | 2000-04-14 | 2007-10-15 | Intercell Ag | Modifizierte peptide enthaltende pharmazeutische präparationen |
| CA2406472A1 (en) * | 2000-04-17 | 2001-10-25 | James E. Rothman | Javelinization of protein antigens to heat shock proteins |
| AU2001266694C1 (en) | 2000-06-02 | 2005-09-01 | University Of Connecticut Health Center | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy |
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| WO2002012281A2 (en) | 2000-08-03 | 2002-02-14 | Johns Hopkins University | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen |
| NZ521694A (en) | 2002-09-30 | 2005-05-27 | Co2 Pac Ltd | Container structure for removal of vacuum pressure |
| US7132109B1 (en) | 2000-10-20 | 2006-11-07 | University Of Connecticut Health Center | Using heat shock proteins to increase immune response |
| BR0206995A (pt) | 2001-02-05 | 2005-08-16 | Stressgen Biotechnologies Corp | Tratamento do vìrus da hepatite b |
| GB0106161D0 (en) * | 2001-03-13 | 2001-05-02 | King S College London | Immunomodulators |
| US20040043419A1 (en) * | 2001-04-17 | 2004-03-04 | Rothman James E. | Javelinization of protein antigens to heat shock proteins |
| IL160511A0 (en) | 2001-08-20 | 2004-07-25 | Univ Connecticut Health Ct | Methods for preparing compositions comprising heat shock proteins or alpha-2-macroglobulin useful for the treatment of cancer and infectious disease |
| CN1304559C (zh) * | 2001-10-09 | 2007-03-14 | 杭州康科生物技术有限公司 | 表达热休克蛋白的溶瘤微生物及其应用 |
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| US6984389B2 (en) | 2002-04-25 | 2006-01-10 | University Of Connecticut Health Center | Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality |
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| US9701725B2 (en) | 2003-05-05 | 2017-07-11 | The Johns Hopkins University | Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
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| WO2005065418A2 (en) * | 2003-12-31 | 2005-07-21 | Board Of Regents, The University Of Texas System | Compositions and methods of use of targeting peptides for diagnosis and therapy |
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| WO2007116409A2 (en) | 2006-04-11 | 2007-10-18 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Improved vaccines comprising multimeric hsp60 peptide carriers |
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| CA2718884C (en) | 2008-03-20 | 2016-11-22 | University Of Miami | Heat shock protein gp96 vaccination and methods of using same |
| ES2651924T3 (es) | 2008-04-18 | 2018-01-30 | The General Hospital Corporation | Inmunoterapias que emplean vacunas autoensamblantes |
| US20110223196A1 (en) * | 2008-11-21 | 2011-09-15 | University Of Miami | Hiv/siv vaccines for the generation of mucosal and systemic immunity |
| EP2270124A1 (en) * | 2009-06-30 | 2011-01-05 | The Procter & Gamble Company | Bleaching compositions comprising a perfume delivery system |
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| JP6744318B2 (ja) | 2015-02-06 | 2020-08-26 | ヒート バイオロジクス，インコーポレイテッド | ワクチンおよび共刺激分子を共発現するベクター |
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| US11666649B2 (en) | 2016-10-11 | 2023-06-06 | University Of Miami | Vectors and vaccine cells for immunity against Zika virus |
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| GB8727030D0 (en) * | 1987-11-18 | 1987-12-23 | Imp Cancer Res Tech | Production of monoclonal antibodies |
| WO1994029459A1 (en) | 1993-06-04 | 1994-12-22 | Whitehead Institute For Biomedical Research | Stress proteins and uses therefor |
| US5348945A (en) | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| IL99821A (en) * | 1991-10-22 | 1996-07-23 | Yeda Res & Dev | Antitumor vaccines comprising cells transfected with a gene encoding human il-6 |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| GB9223816D0 (en) * | 1992-11-13 | 1993-01-06 | Medical Res Council | Heat shock proteins and the treatment of tumours |
| US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5750119A (en) * | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
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| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
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| US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| WO1998035705A1 (en) | 1997-02-18 | 1998-08-20 | Whitehead Institute For Biomedical Research | Use of heat shock proteins to deliver moieties into cells |
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| EP1829551B1 (en) | 1998-02-20 | 2010-09-29 | University of Miami | Modified heat shock protein-antigenic peptide complex |
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- 1996-08-16 IL IL12321996A patent/IL123219A0/xx unknown
- 1996-08-16 IL IL12321896A patent/IL123218A0/xx unknown
- 1996-08-16 HU HU9802819A patent/HUP9802819A2/hu unknown
- 1996-08-16 AU AU68984/96A patent/AU724399B2/en not_active Ceased
- 1996-08-16 AU AU69528/96A patent/AU712907B2/en not_active Ceased
-
2000
- 2000-02-23 US US09/511,453 patent/US6605464B1/en not_active Expired - Fee Related
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2001
- 2001-02-27 US US09/794,832 patent/US6673348B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,529 patent/US6641812B2/en not_active Expired - Fee Related
- 2001-02-27 US US09/794,517 patent/US6656679B2/en not_active Expired - Fee Related
- 2001-08-09 US US09/925,803 patent/US20020198166A1/en not_active Abandoned
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2002
- 2002-06-13 US US10/170,713 patent/US20030185842A1/en not_active Abandoned
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2003
- 2003-02-14 US US10/367,580 patent/US20040071720A1/en not_active Abandoned
- 2003-02-14 US US10/367,593 patent/US20040071721A1/en not_active Abandoned
- 2003-02-14 US US10/367,658 patent/US20040071724A1/en not_active Abandoned
- 2003-02-14 US US10/367,668 patent/US20040071725A1/en not_active Abandoned
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| FZDE | Discontinued |