CA2225450C - Proteine kinase associee au recepteur de l'interleukine-1 et dosages - Google Patents

Proteine kinase associee au recepteur de l'interleukine-1 et dosages Download PDF

Info

Publication number
CA2225450C
CA2225450C CA002225450A CA2225450A CA2225450C CA 2225450 C CA2225450 C CA 2225450C CA 002225450 A CA002225450 A CA 002225450A CA 2225450 A CA2225450 A CA 2225450A CA 2225450 C CA2225450 C CA 2225450C
Authority
CA
Canada
Prior art keywords
irak
pharmacological agent
receptor
leu
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002225450A
Other languages
English (en)
Other versions
CA2225450A1 (fr
Inventor
Zhaodan Cao
David V. Goeddel
Glenn E. Croston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tularik Inc
Original Assignee
Tularik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tularik Inc filed Critical Tularik Inc
Publication of CA2225450A1 publication Critical patent/CA2225450A1/fr
Application granted granted Critical
Publication of CA2225450C publication Critical patent/CA2225450C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne des protéines kinases humaines associées au récepteur de l'Interleukine-1 (IRAK), les acides nucléiques qui codent les IRAK et les sondes et les armorces d'hybridation moléculaire capables de s'hybrider avec les gènes IRAK et les procédés d'utilisation des compositions en question; en particulier des procédés tels que des dosages de liaison in vitro à base d'IRAK et des dosages de phosphorylation destinés au criblage de banques chimiques pour détecter des composés principaux pour des agents pharmaceutiques.
CA002225450A 1995-06-23 1996-06-05 Proteine kinase associee au recepteur de l'interleukine-1 et dosages Expired - Fee Related CA2225450C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49400695A 1995-06-23 1995-06-23
US08/494,006 1995-06-23
PCT/US1996/009193 WO1997000690A1 (fr) 1995-06-23 1996-06-05 Proteine kinase associee au recepteur de l'interleukine-1 et dosages

Publications (2)

Publication Number Publication Date
CA2225450A1 CA2225450A1 (fr) 1997-01-09
CA2225450C true CA2225450C (fr) 2001-05-29

Family

ID=23962617

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002225450A Expired - Fee Related CA2225450C (fr) 1995-06-23 1996-06-05 Proteine kinase associee au recepteur de l'interleukine-1 et dosages

Country Status (5)

Country Link
EP (1) EP0839045A4 (fr)
JP (1) JPH11509085A (fr)
AU (1) AU702844B2 (fr)
CA (1) CA2225450C (fr)
WO (1) WO1997000690A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932425A (en) * 1997-02-18 1999-08-03 Signal Pharmaceuticals, Inc. Compositions and methods for modulating cellular NF-κB activation
US5965421A (en) * 1997-11-26 1999-10-12 Human Genome Sciences, Inc. Human IRAK-2
US6262228B1 (en) * 1998-08-17 2001-07-17 Tularik Inc. IRAK3 polypeptides and methods
GB9913180D0 (en) * 1999-06-08 1999-08-04 Glaxo Group Ltd Interleukin-1 receptor associated kinases
US6965023B2 (en) 2000-11-17 2005-11-15 The Burnham Institute Death domain proteins
AU2002217962A1 (en) * 2000-11-17 2002-05-27 The Burnham Institute Death domain proteins
WO2005052132A2 (fr) * 2003-11-24 2005-06-09 Exelixis, Inc Utilisation de modulateurs de la morphogenese de ramification comme genes modificateurs de la morphogenese de ramification et leurs procedes d'utilisation

Also Published As

Publication number Publication date
AU702844B2 (en) 1999-03-04
EP0839045A1 (fr) 1998-05-06
EP0839045A4 (fr) 1999-06-09
AU6176696A (en) 1997-01-22
WO1997000690A1 (fr) 1997-01-09
JPH11509085A (ja) 1999-08-17
CA2225450A1 (fr) 1997-01-09

Similar Documents

Publication Publication Date Title
Wesche et al. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
US5563039A (en) TNF receptor-associated intracellular signaling proteins and methods of use
AU725477B2 (en) IKK-beta proteins, nucleic acids and methods
AU724178B2 (en) NIK proteins, nucleic acids and methods
AU719774B2 (en) IkB kinases
KR100536394B1 (ko) Fas/ap01수용체들의기능조절인자
US20020119517A1 (en) Leptin induced genes
AU726294B2 (en) Ikk-alpha proteins, nucleic acids and methods
US6280955B1 (en) Interleukin-1 receptor accessory proteins, nucleic acids and methods
WO2000052173A2 (fr) Homologues de sphingosine kinase humaine clones
US6222019B1 (en) Human IRAK-2 antibodies
CA2225450C (fr) Proteine kinase associee au recepteur de l'interleukine-1 et dosages
US5654397A (en) Interleukin-1 receptor-associated protein kinase and assays
US5618693A (en) Interleukin-2 signal transducers and binding assays
AU706887B2 (en) Novel protein - TRAF6
US20020147147A1 (en) Nucleic acid molecules encoding a protein interacting with the chemokine receptor CCR5 or other chemokine receptor family members
WO1998001541A1 (fr) Proteine kinase associee a traf-2 et dosages
AU5368396A (en) Human stat4
US5891719A (en) IKAP nucleic acids
JP2001517430A (ja) ヒトＳｔｅ２０様ストレス活性化セリン／スレオニンキナーゼ
US6110690A (en) SODD-specific antibodies and methods
WO2001038526A1 (fr) Récepteur de tnf humain
CA2303003A1 (fr) Genes ucp3
KR20020047289A (ko) 인간 타이로신키나제 에이치씨케이에 결합하는 인간단백질 및 그것을 코드하는 유전자

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed