CA2224867A1 - Intermediaires de proteines contre l'obesite, leur preparation et leur utilisation - Google Patents

Intermediaires de proteines contre l'obesite, leur preparation et leur utilisation Download PDF

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Publication number
CA2224867A1
CA2224867A1 CA 2224867 CA2224867A CA2224867A1 CA 2224867 A1 CA2224867 A1 CA 2224867A1 CA 2224867 CA2224867 CA 2224867 CA 2224867 A CA2224867 A CA 2224867A CA 2224867 A1 CA2224867 A1 CA 2224867A1
Authority
CA
Canada
Prior art keywords
leu
ser
gln
gly
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2224867
Other languages
English (en)
Inventor
John Edward Hale
Warren Cameron Mackellar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2224867A1 publication Critical patent/CA2224867A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des protéines contre l'obésité, qui régulent le tissu adipeux lorsqu'on les administre à un patient. Elle concerne l'avant-dernier intermédiaire dans la voie de renaturation de la protéine contre l'obésité. Elle concerne, de plus, la préparation dudit intermédiaire, ainsi que son utilisation afin de préparer une protéine biologiquement active contre l'obésité ou un analogue de celle-ci.
CA 2224867 1995-06-22 1996-06-20 Intermediaires de proteines contre l'obesite, leur preparation et leur utilisation Abandoned CA2224867A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45195P 1995-06-22 1995-06-22
US60/000,451 1995-06-22

Publications (1)

Publication Number Publication Date
CA2224867A1 true CA2224867A1 (fr) 1997-01-09

Family

ID=21691591

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2224867 Abandoned CA2224867A1 (fr) 1995-06-22 1996-06-20 Intermediaires de proteines contre l'obesite, leur preparation et leur utilisation

Country Status (5)

Country Link
EP (1) EP0833835A4 (fr)
JP (1) JPH11508134A (fr)
AU (1) AU6284896A (fr)
CA (1) CA2224867A1 (fr)
WO (1) WO1997000886A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2217698A1 (fr) * 1996-12-20 1998-06-20 Eli Lilly And Company Proteines contre l'obesite
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
DE10059336A1 (de) * 2000-11-29 2002-06-13 Scil Proteins Gmbh Herstellung von rekombinantem BMP-2
ATE475094T1 (de) 2001-10-22 2010-08-15 Amgen Inc Verwendung von leptin zur behandlung von lipoatrophie im menschen und verfahren zur bestimmmung einer prädisposition gegenüber der behandlung
EP2416797A4 (fr) 2009-04-10 2013-04-24 Amylin Pharmaceuticals Llc Composés agonistes de l'amyline pour mammifères ayant une carence en strogènes
MX351128B (es) 2010-09-28 2017-10-03 Aegerion Pharmaceuticals Inc Polipeptidos manipulados que tienen duracion de accion incrementada.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE241642T1 (de) * 1993-02-04 2003-06-15 Denzyme Aps Verbessertes verfahren zur rückfaltung der proteine
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5594101A (en) * 1995-03-03 1997-01-14 Eli Lilly And Company Anti-obesity proteins
GB9509164D0 (en) * 1995-05-05 1995-06-28 Smithkline Beecham Plc Novel compounds
ES2216055T3 (es) * 1995-08-17 2004-10-16 Amgen Inc Metodos para reducir o mantener niveles reducidos de lipidos en sangre usando composiciones de proteina ob.

Also Published As

Publication number Publication date
WO1997000886A1 (fr) 1997-01-09
JPH11508134A (ja) 1999-07-21
AU6284896A (en) 1997-01-22
EP0833835A4 (fr) 1999-05-26
EP0833835A1 (fr) 1998-04-08

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