CA2222878A1 - Biological cell sample holder for use in infrared and/or raman spectroscopy analysis - Google Patents
Biological cell sample holder for use in infrared and/or raman spectroscopy analysis Download PDFInfo
- Publication number
- CA2222878A1 CA2222878A1 CA002222878A CA2222878A CA2222878A1 CA 2222878 A1 CA2222878 A1 CA 2222878A1 CA 002222878 A CA002222878 A CA 002222878A CA 2222878 A CA2222878 A CA 2222878A CA 2222878 A1 CA2222878 A1 CA 2222878A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- window
- sample holder
- infrared
- frit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000001069 Raman spectroscopy Methods 0.000 title claims abstract description 15
- 238000004566 IR spectroscopy Methods 0.000 title abstract description 13
- 238000004458 analytical method Methods 0.000 title description 11
- 239000012530 fluid Substances 0.000 claims abstract description 40
- 239000011148 porous material Substances 0.000 claims abstract description 9
- 238000002460 vibrational spectroscopy Methods 0.000 claims description 18
- 238000004611 spectroscopical analysis Methods 0.000 claims description 7
- 238000004891 communication Methods 0.000 claims description 3
- 210000002445 nipple Anatomy 0.000 abstract description 5
- 210000004027 cell Anatomy 0.000 description 288
- 239000000523 sample Substances 0.000 description 86
- 238000000034 method Methods 0.000 description 43
- 239000000725 suspension Substances 0.000 description 26
- 239000000463 material Substances 0.000 description 21
- 201000010099 disease Diseases 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 239000000834 fixative Substances 0.000 description 17
- 238000001228 spectrum Methods 0.000 description 16
- 230000003595 spectral effect Effects 0.000 description 15
- 239000002609 medium Substances 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 10
- 238000005406 washing Methods 0.000 description 10
- 201000011510 cancer Diseases 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 238000003828 vacuum filtration Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000001845 vibrational spectrum Methods 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000010183 spectrum analysis Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- 210000003679 cervix uteri Anatomy 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- -1 polyethylene Polymers 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 4
- 230000002380 cytological effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 238000005065 mining Methods 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 229920000573 polyethylene Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002991 molded plastic Substances 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 238000001945 resonance Rayleigh scattering spectroscopy Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000005464 sample preparation method Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 101100353161 Drosophila melanogaster prel gene Proteins 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 238000004497 NIR spectroscopy Methods 0.000 description 1
- 208000016012 Phenotypic abnormality Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000008385 Urogenital Neoplasms Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 239000011111 cardboard Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 229940066491 mucolytics Drugs 0.000 description 1
- 238000002095 near-infrared Raman spectroscopy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000009595 pap smear Methods 0.000 description 1
- 239000011087 paperboard Substances 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000001055 reflectance spectroscopy Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 208000037964 urogenital cancer Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
Landscapes
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/485,366 | 1995-06-07 | ||
| US08/485,366 US5733507A (en) | 1995-06-07 | 1995-06-07 | Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2222878A1 true CA2222878A1 (en) | 1996-12-19 |
Family
ID=23927876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002222878A Abandoned CA2222878A1 (en) | 1995-06-07 | 1996-06-06 | Biological cell sample holder for use in infrared and/or raman spectroscopy analysis |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5733507A (https=) |
| EP (1) | EP0830584A1 (https=) |
| JP (1) | JPH11507724A (https=) |
| AU (1) | AU6095796A (https=) |
| CA (1) | CA2222878A1 (https=) |
| TW (1) | TW319694B (https=) |
| WO (1) | WO1996041153A1 (https=) |
| ZA (1) | ZA964606B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5848977A (en) * | 1996-02-16 | 1998-12-15 | Inphocyte, Inc. | Sample holder for cells |
| AUPN825796A0 (en) | 1996-02-26 | 1996-03-14 | Ashdown, Martin | The application of infrared (ir) spectrometry to the investigations of components of blood and other body fluids |
| DE19729352A1 (de) * | 1997-07-09 | 1999-01-14 | Basf Ag | Zentrifugierverfahren zur Probencharakterisierung |
| US5945674A (en) * | 1997-07-30 | 1999-08-31 | Vysis, Inc. | Method of identifying cellular types in a biological sample supported on an absorptive substrate by infrared spectroscopy |
| WO2000043775A1 (en) * | 1999-01-22 | 2000-07-27 | Cytospec | Method of characterization of biological entities |
| US6270986B1 (en) * | 1999-02-16 | 2001-08-07 | Patrick T. T. Wong | Method of preserving biological tissue specimens and method of infrared spectroscopic analysis which avoids the effects of polymorphs |
| US6205354B1 (en) | 1999-06-18 | 2001-03-20 | University Of Utah | Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue |
| US20030068829A1 (en) * | 2001-06-25 | 2003-04-10 | Symyx Technologies, Inc. | High throughput crystallographic screening of materials |
| US20050203578A1 (en) * | 2001-08-15 | 2005-09-15 | Weiner Michael L. | Process and apparatus for treating biological organisms |
| EP1436199A1 (en) * | 2001-10-19 | 2004-07-14 | MonoGen, Inc. | Specimen vial sealing apparatus and method |
| US7039452B2 (en) | 2002-12-19 | 2006-05-02 | The University Of Utah Research Foundation | Method and apparatus for Raman imaging of macular pigments |
| US6852527B2 (en) * | 2002-06-06 | 2005-02-08 | Inovyx, Inc. | Apparatus and method for the measurement of cells in biological samples |
| US7361313B2 (en) * | 2003-02-18 | 2008-04-22 | Intel Corporation | Methods for uniform metal impregnation into a nanoporous material |
| US20040254479A1 (en) * | 2003-02-20 | 2004-12-16 | John Fralick | Bio-photonic feedback control software and database |
| IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| EP2341128A1 (en) * | 2003-12-24 | 2011-07-06 | GlycoFi, Inc. | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins |
| US20050278184A1 (en) * | 2004-06-10 | 2005-12-15 | John Fralick | Bio-photonic feedback control software and database |
| GB0415438D0 (en) * | 2004-07-09 | 2004-08-11 | Imp College Innovations Ltd | Spectroscopic support |
| US7365839B2 (en) * | 2004-11-03 | 2008-04-29 | Nu Skin International, Inc. | Process and compositions for synthetic calibration of bio-photonic scanners |
| US7842247B2 (en) | 2005-08-19 | 2010-11-30 | Canadian Blood Services | Sample holder for dynamic light scattering |
| US8263360B2 (en) * | 2006-01-30 | 2012-09-11 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Hydrophilic IR transparent membrane, spectroscopic sample holder comprising same and method of using same |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| WO2008079280A1 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| GB2453558A (en) * | 2007-10-10 | 2009-04-15 | Triton Technology Ltd | Sample holder for a thermo-mechanical analyser |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| EP2237887A2 (en) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Device for the study of living cells |
| CN102257122B (zh) | 2008-12-16 | 2015-07-29 | Emd密理博公司 | 搅拌槽反应器及方法 |
| GB2466442A (en) * | 2008-12-18 | 2010-06-23 | Dublin Inst Of Technology | A system to analyze a sample on a slide using Raman spectroscopy on an identified area of interest |
| EP2230277B1 (en) | 2009-03-12 | 2012-07-04 | Corning Incorporated | Composites and methods of making and using the composites |
| CN107312062B (zh) | 2010-05-17 | 2021-03-16 | Emd密理博公司 | 用于纯化生物分子的刺激响应性聚合物 |
| JP2016118389A (ja) * | 2013-02-28 | 2016-06-30 | 株式会社日立ハイテクノロジーズ | 相互作用解析装置 |
| FR3009622B1 (fr) * | 2013-08-09 | 2015-08-07 | Novacyt | Procede et dispositif de lavage d'un dispositif de pipetage-distribution |
| US10293276B2 (en) * | 2015-03-06 | 2019-05-21 | Horizon Technology, Inc. | Water separation from solvent |
| EP3351921A4 (en) | 2015-09-14 | 2019-08-21 | National University Corporation Shiga University OF Medical Science | CELL HOLDING SUBSTRATE HOLDER FOR PREPARING AN OBSERVATION TEST, KIT THEREFOR AND METHOD FOR PREPARING AN OBSERVATION TEST |
| PT3420334T (pt) * | 2016-02-24 | 2020-12-17 | Partnership For Clean Competition | Dispositivo de multicamadas para separar componentes sanguíneos e seu uso |
| DE102016204234A1 (de) * | 2016-03-15 | 2017-09-21 | Robert Bosch Gmbh | Mikrofluidische Vorrichtung und Verfahren zur Durchführung von chemischen, biochemischen und/oder biologischen Untersuchungen |
| JP2018169489A (ja) * | 2017-03-30 | 2018-11-01 | 一般社団法人白亜会 | フィルター付きスライドグラス |
| DK202170004A1 (en) * | 2021-01-04 | 2022-07-06 | Hyspec Medtech Ivs | A spectral imaging system arranged for identifying benign tissue samples, and a method of using said system. |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1311017A (en) * | 1919-07-22 | Jean v | ||
| US3521963A (en) * | 1965-08-25 | 1970-07-28 | Morris Bader | Radiation absorption test cell |
| US3379083A (en) * | 1965-11-19 | 1968-04-23 | Oberg Mfg Co Inc | Machineable headed punch |
| US3515490A (en) * | 1967-04-11 | 1970-06-02 | Philips Corp | Sample cell for detection of an atmospheric contaminant by internal reflection spectrometry |
| BE758948A (fr) * | 1969-11-18 | 1971-05-13 | Cornell Aeronautical Labor Inc | Appareil destine a identifier diverses particules microstructurees a l'interieur d'un fluide |
| DE2242563A1 (de) * | 1972-08-30 | 1974-03-21 | Nuclear Research Associates | Anordnung zur analyse biologischer zellen |
| SE399768B (sv) * | 1975-09-29 | 1978-02-27 | Lilja Jan E | Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet |
| DE2935812A1 (de) * | 1979-09-05 | 1981-03-12 | Fa. Carl Zeiss, 7920 Heidenheim | Verfahren zur werkstoffpruefung |
| IL68507A (en) * | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
| US4570638A (en) * | 1983-10-14 | 1986-02-18 | Somanetics Corporation | Method and apparatus for spectral transmissibility examination and analysis |
| US4660971A (en) * | 1984-05-03 | 1987-04-28 | Becton, Dickinson And Company | Optical features of flow cytometry apparatus |
| US4978503A (en) * | 1984-06-13 | 1990-12-18 | Ares-Serono Research & Development Limited Partnership | Devices for use in chemical test procedures |
| IL78854A (en) * | 1985-05-31 | 1991-11-21 | Murex Corp | Biological fluid diagnostic device |
| US4702834A (en) * | 1986-06-17 | 1987-10-27 | Nalge Company | Plastic filter units having a weld cellulose filter |
| US4787988A (en) * | 1987-02-20 | 1988-11-29 | Biomedical Research And Development Laboratories, Inc. | Cell harvester |
| US5240861A (en) * | 1988-07-29 | 1993-08-31 | Spectrum Medical Industries, Inc. | Device and process for concentrating biologic specimens in liquid form |
| US5147609A (en) * | 1989-05-19 | 1992-09-15 | Pb Diagnostic Systems, Inc. | Assay element |
| ATE96908T1 (de) * | 1989-06-22 | 1993-11-15 | Univ Catholique Louvain | Verfahren und vorrichtung zur herstellung von proben fuer die chemische analyse von fluessigkeiten mittels infrarot-spektrometrie von trockenen extrakten. |
| JP2839560B2 (ja) * | 1989-07-10 | 1998-12-16 | 株式会社日立製作所 | 粒子懸濁液混合装置，粒子懸濁液混合方法及び粒子計測装置 |
| CA2019865A1 (en) * | 1989-07-12 | 1991-01-12 | Yatin B. Thakore | Device and method for separation of fluid components for component testing |
| CA2005622A1 (en) * | 1989-12-15 | 1991-06-15 | Patrick T.T. Wong | Infrared absorption spectra recording, high pressure sample holder |
| CA2007267C (en) * | 1990-01-05 | 1995-05-09 | Patrick T.T. Wong | Non-pressure-dependancy infrared absorption spectra recording, sample cell |
| CA2008831C (en) * | 1990-01-29 | 1996-03-26 | Patrick T.T. Wong | Method of detecting the presence of anomalies in biological tissues and cells in natural and cultured form by infrared spectroscopy |
| US5282978A (en) * | 1990-07-09 | 1994-02-01 | Cytyc Corporation | Specimen processor method and apparatus |
| US5197470A (en) * | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
| DE4030699C1 (https=) * | 1990-09-28 | 1991-10-10 | Bruker Analytische Messtechnik Gmbh, 7512 Rheinstetten, De | |
| GB9026538D0 (en) * | 1990-12-06 | 1991-01-23 | Knight Scient Ltd | Filtration arrangement |
| US5168162A (en) * | 1991-02-04 | 1992-12-01 | Cornell Research Foundation, Inc. | Method of detecting the presence of anomalies in exfoliated cells using infrared spectroscopy |
| JP2972367B2 (ja) * | 1991-03-20 | 1999-11-08 | 株式会社日立製作所 | 細胞分析装置 |
| US5139685A (en) * | 1991-03-26 | 1992-08-18 | Gds Technology, Inc. | Blood separation filter assembly and method |
| WO1993000580A1 (en) * | 1991-06-25 | 1993-01-07 | Minnesota Mining And Manufacturing Company | Spectroscopic sample holder and method for using same |
| US5470757A (en) * | 1991-06-25 | 1995-11-28 | Minnesota Mining And Manufacturing Company | Spectroscopic sample holder and method for using same |
| US5408306A (en) * | 1992-05-01 | 1995-04-18 | Spectro Incorporated | Rotating disk electrode method and apparatus for multi-elemental determination of concentration of particles in used oil |
| US5308483A (en) * | 1992-08-27 | 1994-05-03 | Gelman Sciences Inc. | Microporous filtration funnel assembly |
| IT1272120B (it) * | 1993-03-22 | 1997-06-11 | Bio Rad Spd Srl | Camera di misurazione per citometro a flusso |
| JP3234370B2 (ja) * | 1993-10-01 | 2001-12-04 | タイホー工業株式会社 | 検体採取装置 |
-
1995
- 1995-06-07 US US08/485,366 patent/US5733507A/en not_active Expired - Fee Related
-
1996
- 1996-06-04 ZA ZA964606A patent/ZA964606B/xx unknown
- 1996-06-06 AU AU60957/96A patent/AU6095796A/en not_active Abandoned
- 1996-06-06 WO PCT/US1996/009304 patent/WO1996041153A1/en not_active Ceased
- 1996-06-06 JP JP9501656A patent/JPH11507724A/ja active Pending
- 1996-06-06 EP EP96918258A patent/EP0830584A1/en not_active Withdrawn
- 1996-06-06 CA CA002222878A patent/CA2222878A1/en not_active Abandoned
- 1996-06-19 TW TW085107424A patent/TW319694B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11507724A (ja) | 1999-07-06 |
| WO1996041153A1 (en) | 1996-12-19 |
| US5733507A (en) | 1998-03-31 |
| ZA964606B (en) | 1997-03-12 |
| EP0830584A1 (en) | 1998-03-25 |
| TW319694B (https=) | 1997-11-11 |
| AU6095796A (en) | 1996-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5733507A (en) | Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder | |
| EP0654972B1 (en) | Method and apparatus for obtaining cytology monolayers | |
| US6296764B1 (en) | Apparatus for mixing and separating particulate matter from a fluid | |
| US5849505A (en) | Liquid specimen container and attachable testing modules | |
| CA2299629C (en) | Method and apparatus for separating particulate matter from a liquid specimen | |
| US6830935B1 (en) | Method for mixing and processing specimen samples | |
| AU2024213142B2 (en) | Automated sample deposition and staining systems and associated methods | |
| CA2336093C (en) | Improved method for mixing and processing specimen samples | |
| US5848977A (en) | Sample holder for cells | |
| US6106483A (en) | Apparatus for obtaining a cytology monolayer | |
| USRE39457E1 (en) | Liquid specimen container and attachable testing modules | |
| WO1996040408A1 (en) | Method and apparatus for solid-liquid separation | |
| MXPA00001286A (en) | Method and apparatus for separating particulate matter from a liquid specimen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |