CA2215930C - Procede de preparation d'antibiotiques de la famille des anthracyclines - Google Patents

Procede de preparation d'antibiotiques de la famille des anthracyclines Download PDF

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Publication number
CA2215930C
CA2215930C CA002215930A CA2215930A CA2215930C CA 2215930 C CA2215930 C CA 2215930C CA 002215930 A CA002215930 A CA 002215930A CA 2215930 A CA2215930 A CA 2215930A CA 2215930 C CA2215930 C CA 2215930C
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CA
Canada
Prior art keywords
formula
group
give
defined above
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002215930A
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English (en)
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CA2215930A1 (fr
Inventor
Ettore Bigatti
Francesco Bianchi
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SICOR Societa Italiana Corticosteroidi SRL
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SICOR Societa Italiana Corticosteroidi SRL
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Filing date
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Priority claimed from IT95MI000566A external-priority patent/IT1275953B1/it
Application filed by SICOR Societa Italiana Corticosteroidi SRL filed Critical SICOR Societa Italiana Corticosteroidi SRL
Publication of CA2215930A1 publication Critical patent/CA2215930A1/fr
Application granted granted Critical
Publication of CA2215930C publication Critical patent/CA2215930C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Procédé de préparation d'antibiotiques de la famille des anthracyclines de formule (A) dans laquelle R<1> représente hydrogène, OH ou OCOR<2>, où R<2> représente un groupe alkyle C1-C4, ce procédé consistant à épimériser le groupe 4' hydroxy du reste de daunosamine par substitution nucléophile d'un groupe triflate avec un carboxylate, cette épimérisation s'effectuant sur la molécule entière, les groupes hydroxy étant protégés, puis à procéder à une transformation ultérieure afin d'obtenir le produit final.
CA002215930A 1995-03-22 1996-03-19 Procede de preparation d'antibiotiques de la famille des anthracyclines Expired - Fee Related CA2215930C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT95MI000566A IT1275953B1 (it) 1995-03-22 1995-03-22 Procedimento per la preparazione di antibiotici della classe delle antracicline
ITMI95A000566 1995-03-22
PCT/EP1996/001174 WO1996029335A1 (fr) 1995-03-22 1996-03-19 Procede de preparation d'antibiotiques de la famille des anthracyclines

Publications (2)

Publication Number Publication Date
CA2215930A1 CA2215930A1 (fr) 1996-09-26
CA2215930C true CA2215930C (fr) 2007-08-21

Family

ID=38434569

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215930A Expired - Fee Related CA2215930C (fr) 1995-03-22 1996-03-19 Procede de preparation d'antibiotiques de la famille des anthracyclines

Country Status (1)

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CA (1) CA2215930C (fr)

Also Published As

Publication number Publication date
CA2215930A1 (fr) 1996-09-26

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