CA2214789A1 - Carbopeptoides et carbonucleotoides - Google Patents

Carbopeptoides et carbonucleotoides Download PDF

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Publication number
CA2214789A1
CA2214789A1 CA 2214789 CA2214789A CA2214789A1 CA 2214789 A1 CA2214789 A1 CA 2214789A1 CA 2214789 CA2214789 CA 2214789 CA 2214789 A CA2214789 A CA 2214789A CA 2214789 A1 CA2214789 A1 CA 2214789A1
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CA
Canada
Prior art keywords
equivalents
carbon
carbohydrate
anomeric
otes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2214789
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English (en)
Inventor
Kyriacos C. Nicolaou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2214789A1 publication Critical patent/CA2214789A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/20—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/20—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D309/22—Radicals substituted by oxygen atoms
    • C07D309/24—Methylol radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Structural Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des banques dont la synthèse est obtenue avec des carbopeptoïdes et des carbonucléotoïdes oligomères. Les carbopeptoïdes sont des oligosides ayant des sous-unités glucidiques reliées entre elles par des liaisons amides. Les carbonucléotoïdes sont des oligosides ayant des sous-unités glucidiques reliées entre elles par des liaisons phosphodiester. Il est possible de constituer des banques de carbopeptoïdes et de carbonucléotoïdes au moyen de synthétiseurs automatiques de polypeptides et de polynucléotides, respectivement.
CA 2214789 1995-03-08 1996-03-08 Carbopeptoides et carbonucleotoides Abandoned CA2214789A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40103995A 1995-03-08 1995-03-08
US08/401,039 1995-03-08

Publications (1)

Publication Number Publication Date
CA2214789A1 true CA2214789A1 (fr) 1996-09-12

Family

ID=23586019

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2214789 Abandoned CA2214789A1 (fr) 1995-03-08 1996-03-08 Carbopeptoides et carbonucleotoides

Country Status (4)

Country Link
EP (1) EP0827406A1 (fr)
AU (1) AU717099B2 (fr)
CA (1) CA2214789A1 (fr)
WO (1) WO1996027379A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006437A2 (fr) 1996-08-13 1998-02-19 Chiron Corporation Compositions et procedes d'apport de polynucleotides
US5756712A (en) * 1997-01-23 1998-05-26 E. I. Du Pont De Nemours And Company Peptidodisaccharides as oligosaccharide mimetics
US5919967A (en) * 1997-04-11 1999-07-06 Epix Medical, Inc. Process for synthesizing phosphodiesters
US6197332B1 (en) 1997-08-13 2001-03-06 Chiron Corporation Lipid-conjugated polyamide compounds and related compositions and methods thereof
JP7296459B2 (ja) * 2018-11-22 2023-06-22 イドーシア ファーマシューティカルズ リミテッド Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅに対する安定なワクチン
CN110526950B (zh) * 2019-09-23 2023-08-04 济南山目生物医药科技有限公司 一种alpha-五-O-乙酰基甘露糖的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212298A (en) * 1989-08-16 1993-05-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
AU7193494A (en) * 1993-07-21 1995-02-20 Oxford Glycosystems Ltd Saccharides, their synthesis and use
WO1995018971A1 (fr) * 1994-01-11 1995-07-13 Affymax Technologies N.V. Procede de synthese chimique en phase gazeuse de glycoconjugues

Also Published As

Publication number Publication date
EP0827406A4 (fr) 1998-03-11
AU717099B2 (en) 2000-03-16
AU5188296A (en) 1996-09-23
WO1996027379A1 (fr) 1996-09-12
EP0827406A1 (fr) 1998-03-11

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