CA2211417A1 - Enzyme .alpha.-galactosidase recombinee - Google Patents
Enzyme .alpha.-galactosidase recombineeInfo
- Publication number
- CA2211417A1 CA2211417A1 CA002211417A CA2211417A CA2211417A1 CA 2211417 A1 CA2211417 A1 CA 2211417A1 CA 002211417 A CA002211417 A CA 002211417A CA 2211417 A CA2211417 A CA 2211417A CA 2211417 A1 CA2211417 A1 CA 2211417A1
- Authority
- CA
- Canada
- Prior art keywords
- galactosidase
- leu
- gly
- ala
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
Cette invention se rapporte à une enzyme recombinée utile dans l'enlèvement des antigènes de type B de la surface de cellules dans des produits sanguins. Cette invention concerne notamment une enzyme .alpha.-galactosidase recombinée du grain de café, un vecteur recombiné codant l'.alpha.-galactosidase du grain de café, des méthodes de clonage et d'expression de l'.alpha.-galactosidase recombinée du grain de café ainsi qu'un procédé d'enlèvement d'antigènes B de la surface de cellules dans des produits sanguins par utilisation de ladite .alpha.-galactosidase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38019495A | 1995-01-30 | 1995-01-30 | |
US08/380,194 | 1995-01-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2211417A1 true CA2211417A1 (fr) | 1996-08-08 |
Family
ID=23500271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002211417A Abandoned CA2211417A1 (fr) | 1995-01-30 | 1996-01-30 | Enzyme .alpha.-galactosidase recombinee |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0807165A4 (fr) |
JP (1) | JPH10513057A (fr) |
AU (1) | AU4772596A (fr) |
CA (1) | CA2211417A1 (fr) |
WO (1) | WO1996023869A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
US7767415B2 (en) | 2001-09-25 | 2010-08-03 | Velico Medical, Inc. | Compositions and methods for modifying blood cell carbohydrates |
CA2696699A1 (fr) | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Conjugues de proteines contenant un saccharide et leurs utilisations |
US20120230974A1 (en) * | 2009-11-17 | 2012-09-13 | Protalix Ltd | Alkaline alpha galactosidase for the treatment of fabry disease |
US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
CN103443270B (zh) | 2011-01-20 | 2017-06-06 | 普罗塔里克斯有限公司 | 用于在植物和植物细胞中表达α‑半乳糖苷酶的核酸构建体 |
CN114752581B (zh) * | 2022-04-20 | 2023-05-26 | 南京工业大学 | 一种α-半乳糖苷酶突变体及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1339101C (fr) * | 1986-06-03 | 1997-07-29 | Nicolaas Overbeeke | Obtention d'alpha-galactosidase de guar et d'alpha-galactisidase apparente du point de vue immunitaire a l'aide d'organismes hotes transformes par des methodes a adn recombinant |
DE69133066T2 (de) * | 1990-01-16 | 2003-03-06 | Ct Ingenieria Genetica Biotech | Verfahren zur Expression heterologischer Gene in der Hefe Pichia Pastoris, Expressionsverfahren und transformierte Mikroorganismen |
US5330901A (en) * | 1991-04-26 | 1994-07-19 | Research Corporation Technologies, Inc. | Expression of human serum albumin in Pichia pastoris |
WO1994009123A1 (fr) * | 1992-10-22 | 1994-04-28 | The New York Blood Center, Inc. | Recyclage d'enzymes utilisees dans la conversion d'erythrocytes des sous-types a, b et ab |
-
1996
- 1996-01-30 WO PCT/US1996/001212 patent/WO1996023869A1/fr not_active Application Discontinuation
- 1996-01-30 AU AU47725/96A patent/AU4772596A/en not_active Abandoned
- 1996-01-30 EP EP96903741A patent/EP0807165A4/fr not_active Withdrawn
- 1996-01-30 CA CA002211417A patent/CA2211417A1/fr not_active Abandoned
- 1996-01-30 JP JP8523663A patent/JPH10513057A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0807165A4 (fr) | 1998-07-15 |
AU4772596A (en) | 1996-08-21 |
WO1996023869A1 (fr) | 1996-08-08 |
EP0807165A1 (fr) | 1997-11-19 |
JPH10513057A (ja) | 1998-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20050131 |