CA2207905A1 - Prevention des fuites se produisant pendant la transition de phase thermotrope dans des liposomes et des cellules biologiques - Google Patents

Prevention des fuites se produisant pendant la transition de phase thermotrope dans des liposomes et des cellules biologiques

Info

Publication number
CA2207905A1
CA2207905A1 CA 2207905 CA2207905A CA2207905A1 CA 2207905 A1 CA2207905 A1 CA 2207905A1 CA 2207905 CA2207905 CA 2207905 CA 2207905 A CA2207905 A CA 2207905A CA 2207905 A1 CA2207905 A1 CA 2207905A1
Authority
CA
Canada
Prior art keywords
liposomes
accordance
proteins
thermal hysteresis
antifreeze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2207905
Other languages
English (en)
Inventor
Lisa M. Hays
John H. Crowe
Lois M. Crowe
Robert E. Feeney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2207905A1 publication Critical patent/CA2207905A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur un procédé de réduction ou d'élimination des fuites des liposomes ou des cellules biologiques se produisant pendant leur refroidissement à la température de transition de phase thermotrope et consistant à introduire dans des liposomes ou des structures cellulaires des protéines à hystérèse thermique. Il s'agit de préférence de protéines ou de glycoprotéines anti-gel provenant d'espèces de poissons polaires. La fraction chromatographique n~ 8 desdites glycoprotéines s'est avérée particulièrement efficace.
CA 2207905 1995-01-05 1995-12-18 Prevention des fuites se produisant pendant la transition de phase thermotrope dans des liposomes et des cellules biologiques Abandoned CA2207905A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36919395A 1995-01-05 1995-01-05
US08/369,193 1995-01-05

Publications (1)

Publication Number Publication Date
CA2207905A1 true CA2207905A1 (fr) 1996-07-11

Family

ID=23454485

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2207905 Abandoned CA2207905A1 (fr) 1995-01-05 1995-12-18 Prevention des fuites se produisant pendant la transition de phase thermotrope dans des liposomes et des cellules biologiques

Country Status (6)

Country Link
EP (1) EP0796088A4 (fr)
JP (1) JPH10511947A (fr)
CN (1) CN1085076C (fr)
AU (1) AU697926B2 (fr)
CA (1) CA2207905A1 (fr)
WO (1) WO1996020695A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315661B (en) 1996-07-26 2000-05-03 Unilever Plc Frozen food product
ES2126516B1 (es) * 1997-03-26 1999-12-01 Univ Barcelona Glicoproteina para proteccion de liposomas.
EP1565165A2 (fr) * 2002-11-26 2005-08-24 Gilead Sciences, Inc. Formulations liposomiques

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173219A (en) * 1986-02-12 1992-12-22 Research Development Foundation Uniform spherical multilamellar liposomes of defined and adjustable size distribution
US5118792A (en) * 1989-05-10 1992-06-02 Dna Plant Technology Corporation Ice crystal growth suppression polypeptides and method of making
AU648028B2 (en) * 1989-05-10 1994-04-14 Dna Plant Technology Corporation Antifreeze polypeptides
US5358931A (en) * 1990-01-17 1994-10-25 The Regents Of The University Of California Interaction of thermal hysteresis proteins with cells and cell membranes and associated applications
DK0511317T3 (da) * 1990-01-17 1999-01-25 Univ California Sammensætning til forbedring af overlevelsen af biologiske materialer
WO1991012718A1 (fr) * 1990-03-01 1991-09-05 Agouron Pharmaceuticals, Inc. Cryoconservation amelioree a l'aide d'un peptide d'hysteresis thermique
US5225182A (en) * 1991-10-31 1993-07-06 Sharma Yash P Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system

Also Published As

Publication number Publication date
CN1085076C (zh) 2002-05-22
AU697926B2 (en) 1998-10-22
CN1216918A (zh) 1999-05-19
JPH10511947A (ja) 1998-11-17
EP0796088A1 (fr) 1997-09-24
EP0796088A4 (fr) 1998-12-09
AU4641696A (en) 1996-07-24
WO1996020695A1 (fr) 1996-07-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead