CA2207617C - Procede de preparation de chlorhydrate de 1-(2'-desoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidine-2-one - Google Patents
Procede de preparation de chlorhydrate de 1-(2'-desoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidine-2-one Download PDFInfo
- Publication number
- CA2207617C CA2207617C CA002207617A CA2207617A CA2207617C CA 2207617 C CA2207617 C CA 2207617C CA 002207617 A CA002207617 A CA 002207617A CA 2207617 A CA2207617 A CA 2207617A CA 2207617 C CA2207617 C CA 2207617C
- Authority
- CA
- Canada
- Prior art keywords
- deoxy
- ribofuranosyl
- difluoro
- aminopyrimidin
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Cette invention concerne un procédé de préparation de chlorhydrate de gemcitabine, procédé consistant à débloquer beta -1-(2'-désoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-aminopyrimidine-2-one avec une quantité catalytique d'une alkylamine en présence de méthanol ou d'éthanol dans un environnement totalement exempt d'eau; à traiter la solution obtenue avec l'acide chlorhydrique et un antisolvant; et à récupérer le chlorhydrate de gemcitabine solide obtenu.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/355,372 US5637688A (en) | 1994-12-13 | 1994-12-13 | Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride |
US08/355,372 | 1994-12-13 | ||
PCT/US1995/014864 WO1996018637A1 (fr) | 1994-12-13 | 1995-11-14 | Procede de preparation de chlorhydrate de 1-(2'-desoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidine-2-one |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2207617A1 CA2207617A1 (fr) | 1996-06-20 |
CA2207617C true CA2207617C (fr) | 2007-06-26 |
Family
ID=38279027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002207617A Expired - Fee Related CA2207617C (fr) | 1994-12-13 | 1995-11-14 | Procede de preparation de chlorhydrate de 1-(2'-desoxy-2',2'-difluoro-d-ribofuranosyl)-4-aminopyrimidine-2-one |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2207617C (fr) |
-
1995
- 1995-11-14 CA CA002207617A patent/CA2207617C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2207617A1 (fr) | 1996-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151116 |