CA2197785A1 - Oligonucleotide conjugates, compositions and methods for splitting ribonucleic acids - Google Patents

Oligonucleotide conjugates, compositions and methods for splitting ribonucleic acids

Info

Publication number
CA2197785A1
CA2197785A1 CA002197785A CA2197785A CA2197785A1 CA 2197785 A1 CA2197785 A1 CA 2197785A1 CA 002197785 A CA002197785 A CA 002197785A CA 2197785 A CA2197785 A CA 2197785A CA 2197785 A1 CA2197785 A1 CA 2197785A1
Authority
CA
Canada
Prior art keywords
oligonucleotide
oligonucleotide according
building blocks
group
target rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002197785A
Other languages
English (en)
French (fr)
Inventor
Dieter Husken
Heinz Moser
Robert Haner
Jonathan Hall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of CA2197785A1 publication Critical patent/CA2197785A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002197785A 1994-09-02 1995-08-30 Oligonucleotide conjugates, compositions and methods for splitting ribonucleic acids Abandoned CA2197785A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2694/94-5 1994-09-02
CH269494 1994-09-02

Publications (1)

Publication Number Publication Date
CA2197785A1 true CA2197785A1 (en) 1996-03-14

Family

ID=4239485

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002197785A Abandoned CA2197785A1 (en) 1994-09-02 1995-08-30 Oligonucleotide conjugates, compositions and methods for splitting ribonucleic acids

Country Status (8)

Country Link
EP (1) EP0778845A1 (fi)
JP (1) JPH10505353A (fi)
AU (1) AU3519095A (fi)
CA (1) CA2197785A1 (fi)
FI (1) FI970696A (fi)
HU (1) HUT77034A (fi)
NO (1) NO970885L (fi)
WO (1) WO1996007667A1 (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798491A (en) * 1993-06-09 1998-08-25 Board Of Regents, The University Of Texas System Multi-mechanistic chemical cleavage using certain metal complexes
US5714328A (en) * 1995-06-07 1998-02-03 Board Of Regents, The University Of Texas System RNA photocleavage using texaphyrins
US6022959A (en) * 1996-08-20 2000-02-08 Pharmacyclics, Inc. Nucleic acids internally-derivatized with a texaphyrin metal complex and uses thereof
ATE236190T1 (de) * 1996-08-20 2003-04-15 Pharmacyclics Inc Nuklein-säuren die mit einem texaphyrin- metallkomplex intern derivatsiert sind und ihre verwendungen
US6255476B1 (en) * 1999-02-22 2001-07-03 Pe Corporation (Ny) Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
KR101040700B1 (ko) * 2006-11-16 2011-06-10 주식회사 엘지화학 테레프탈알데히드의 정제방법
US8263588B2 (en) 2007-04-06 2012-09-11 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
PA8775801A1 (es) 2007-04-06 2009-05-15 Neurocrine Biosciences Inc Antagonista del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559207A (en) * 1989-03-06 1996-09-24 Board Of Regents, University Of Texas Texaphyrin metal complex mediated ester hydrolysis

Also Published As

Publication number Publication date
EP0778845A1 (de) 1997-06-18
HUT77034A (hu) 1998-03-02
FI970696A0 (fi) 1997-02-19
AU3519095A (en) 1996-03-27
FI970696A (fi) 1997-02-19
NO970885L (no) 1997-04-25
NO970885D0 (no) 1997-02-27
JPH10505353A (ja) 1998-05-26
WO1996007667A1 (de) 1996-03-14

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