CA2194795C - Method of measuring gas concentrations and microfabricated sensing device for practicing same - Google Patents
Method of measuring gas concentrations and microfabricated sensing device for practicing same Download PDFInfo
- Publication number
- CA2194795C CA2194795C CA002194795A CA2194795A CA2194795C CA 2194795 C CA2194795 C CA 2194795C CA 002194795 A CA002194795 A CA 002194795A CA 2194795 A CA2194795 A CA 2194795A CA 2194795 C CA2194795 C CA 2194795C
- Authority
- CA
- Canada
- Prior art keywords
- gas
- established
- cre
- gpm
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims description 37
- 239000007789 gas Substances 0.000 claims description 155
- 239000000758 substrate Substances 0.000 claims description 51
- 239000007788 liquid Substances 0.000 claims description 45
- 239000012528 membrane Substances 0.000 claims description 42
- 239000003792 electrolyte Substances 0.000 claims description 38
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 36
- 239000001301 oxygen Substances 0.000 claims description 36
- 229910052760 oxygen Inorganic materials 0.000 claims description 36
- 238000011109 contamination Methods 0.000 claims description 35
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 29
- 229910052737 gold Inorganic materials 0.000 claims description 29
- 239000010931 gold Substances 0.000 claims description 29
- 229910052709 silver Inorganic materials 0.000 claims description 28
- 239000004332 silver Substances 0.000 claims description 28
- 230000004907 flux Effects 0.000 claims description 21
- 108010010803 Gelatin Proteins 0.000 claims description 18
- 229920000159 gelatin Polymers 0.000 claims description 18
- 235000019322 gelatine Nutrition 0.000 claims description 18
- 235000011852 gelatine desserts Nutrition 0.000 claims description 18
- 239000008273 gelatin Substances 0.000 claims description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 10
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 9
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 229920001296 polysiloxane Polymers 0.000 claims description 8
- 239000002322 conducting polymer Substances 0.000 claims description 7
- 229920001940 conductive polymer Polymers 0.000 claims description 7
- 238000006479 redox reaction Methods 0.000 claims description 7
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 6
- 230000002411 adverse Effects 0.000 claims description 6
- 239000002019 doping agent Substances 0.000 claims description 6
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 6
- 239000012491 analyte Substances 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 4
- 230000035699 permeability Effects 0.000 claims description 4
- 239000004971 Cross linker Substances 0.000 claims description 3
- 229910019142 PO4 Inorganic materials 0.000 claims description 3
- 150000004820 halides Chemical class 0.000 claims description 3
- 150000002823 nitrates Chemical class 0.000 claims description 3
- 235000021317 phosphate Nutrition 0.000 claims description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 3
- 229920000767 polyaniline Polymers 0.000 claims description 2
- 229920000123 polythiophene Polymers 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 229920000128 polypyrrole Polymers 0.000 claims 1
- 239000010410 layer Substances 0.000 description 65
- 239000000523 sample Substances 0.000 description 50
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 19
- 239000000463 material Substances 0.000 description 15
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 8
- 229910052710 silicon Inorganic materials 0.000 description 8
- 239000010703 silicon Substances 0.000 description 8
- 235000012431 wafers Nutrition 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- -1 silver ions Chemical class 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- GTKRFUAGOKINCA-UHFFFAOYSA-M chlorosilver;silver Chemical compound [Ag].[Ag]Cl GTKRFUAGOKINCA-UHFFFAOYSA-M 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004642 Polyimide Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920001721 polyimide Polymers 0.000 description 3
- BDJXVNRFAQSMAA-UHFFFAOYSA-N quinhydrone Chemical compound OC1=CC=C(O)C=C1.O=C1C=CC(=O)C=C1 BDJXVNRFAQSMAA-UHFFFAOYSA-N 0.000 description 3
- 229940052881 quinhydrone Drugs 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 238000004082 amperometric method Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 108010025899 gelatin film Proteins 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000012876 topography Methods 0.000 description 2
- 238000001075 voltammogram Methods 0.000 description 2
- ZQXCQTAELHSNAT-UHFFFAOYSA-N 1-chloro-3-nitro-5-(trifluoromethyl)benzene Chemical compound [O-][N+](=O)C1=CC(Cl)=CC(C(F)(F)F)=C1 ZQXCQTAELHSNAT-UHFFFAOYSA-N 0.000 description 1
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- HNLITPNLXYBFGZ-UHFFFAOYSA-N CC1=CC=C(O)C(O[SiH2]C=2C(=CC=CC=2)O)=C1C Chemical compound CC1=CC=C(O)C(O[SiH2]C=2C(=CC=CC=2)O)=C1C HNLITPNLXYBFGZ-UHFFFAOYSA-N 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 229910001080 W alloy Inorganic materials 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 1
- 238000003411 electrode reaction Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000004868 gas analysis Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000004313 potentiometry Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000682 scanning probe acoustic microscopy Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- MAKDTFFYCIMFQP-UHFFFAOYSA-N titanium tungsten Chemical compound [Ti].[W] MAKDTFFYCIMFQP-UHFFFAOYSA-N 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/404—Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid, e.g. Clark-type oxygen sensors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/274,460 US5514253A (en) | 1994-07-13 | 1994-07-13 | Method of measuring gas concentrations and microfabricated sensing device for practicing same |
| US08/274,460 | 1994-07-13 | ||
| PCT/US1995/009396 WO1996002829A1 (en) | 1994-07-13 | 1995-07-07 | Method of measuring gas concentrations and microfabricated sensing device for practicing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2194795A1 CA2194795A1 (en) | 1996-02-01 |
| CA2194795C true CA2194795C (en) | 2001-03-13 |
Family
ID=23048289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002194795A Expired - Lifetime CA2194795C (en) | 1994-07-13 | 1995-07-07 | Method of measuring gas concentrations and microfabricated sensing device for practicing same |
Country Status (9)
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3255942B2 (ja) | 1991-06-19 | 2002-02-12 | 株式会社半導体エネルギー研究所 | 逆スタガ薄膜トランジスタの作製方法 |
| KR100369491B1 (ko) * | 1994-08-16 | 2003-08-19 | 벨로이트 테크놀로지스 인코포레이티드 | 정역학적셀프로딩편향제어롤에서롤쉘의축방향위치부여장치 |
| DE69809391T2 (de) | 1997-02-06 | 2003-07-10 | Therasense, Inc. | Kleinvolumiger sensor zur in-vitro bestimmung |
| US7885697B2 (en) | 2004-07-13 | 2011-02-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US6039055A (en) * | 1998-01-08 | 2000-03-21 | International Business Machines Corporation | Wafer cleaning with dissolved gas concentration control |
| US6030827A (en) * | 1998-01-23 | 2000-02-29 | I-Stat Corporation | Microfabricated aperture-based sensor |
| US6444474B1 (en) * | 1998-04-22 | 2002-09-03 | Eltron Research, Inc. | Microfluidic system for measurement of total organic carbon |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6251260B1 (en) | 1998-08-24 | 2001-06-26 | Therasense, Inc. | Potentiometric sensors for analytic determination |
| US6338790B1 (en) | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
| US6591125B1 (en) | 2000-06-27 | 2003-07-08 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
| EP1192269A2 (en) | 1999-06-18 | 2002-04-03 | Therasense, Inc. | MASS TRANSPORT LIMITED i IN VIVO /i ANALYTE SENSOR |
| US6616819B1 (en) | 1999-11-04 | 2003-09-09 | Therasense, Inc. | Small volume in vitro analyte sensor and methods |
| KR100379792B1 (ko) * | 2000-06-12 | 2003-04-11 | 주식회사 아이센스 | 마이크로 칩형 이산화탄소 기체센서 |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US7041468B2 (en) | 2001-04-02 | 2006-05-09 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
| US6896778B2 (en) * | 2001-06-04 | 2005-05-24 | Epocal Inc. | Electrode module |
| US7214300B2 (en) * | 2001-06-04 | 2007-05-08 | Epocal Inc. | Integrated electrokinetic devices and methods of manufacture |
| EP1427816A4 (en) | 2001-09-18 | 2004-12-01 | Clontech Lab Inc | METHOD FOR THE PRODUCTION OF ADENOVIRUS VECTORS, BASED ON A SPECIFIC RECOMBINASE |
| US6908537B2 (en) * | 2001-10-22 | 2005-06-21 | Perkinelmer Instruments Llc | Electrochemical sensors having nonporous working electrode |
| US6955750B2 (en) * | 2001-10-22 | 2005-10-18 | Perkinelmer Instruments Llc | Electrochemical sensor compensated for relative humidity |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US20050180845A1 (en) * | 2002-04-04 | 2005-08-18 | Vreeke Mark S. | Miniature/micro-scale power generation system |
| US20040018577A1 (en) * | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
| US7767068B2 (en) | 2002-12-02 | 2010-08-03 | Epocal Inc. | Heterogeneous membrane electrodes |
| US7094330B2 (en) | 2002-12-02 | 2006-08-22 | Epocal Inc. | Heterogeneous membrane electrodes |
| US7842234B2 (en) * | 2002-12-02 | 2010-11-30 | Epocal Inc. | Diagnostic devices incorporating fluidics and methods of manufacture |
| US7811231B2 (en) | 2002-12-31 | 2010-10-12 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
| US8771183B2 (en) | 2004-02-17 | 2014-07-08 | Abbott Diabetes Care Inc. | Method and system for providing data communication in continuous glucose monitoring and management system |
| US7587287B2 (en) | 2003-04-04 | 2009-09-08 | Abbott Diabetes Care Inc. | Method and system for transferring analyte test data |
| US8066639B2 (en) | 2003-06-10 | 2011-11-29 | Abbott Diabetes Care Inc. | Glucose measuring device for use in personal area network |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US8626257B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | Analyte sensor |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US7722817B2 (en) * | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| US8615282B2 (en) | 2004-07-13 | 2013-12-24 | Dexcom, Inc. | Analyte sensor |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
| US8425416B2 (en) | 2006-10-04 | 2013-04-23 | Dexcom, Inc. | Analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
| US8364230B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| US8425417B2 (en) | 2003-12-05 | 2013-04-23 | Dexcom, Inc. | Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
| US8112240B2 (en) | 2005-04-29 | 2012-02-07 | Abbott Diabetes Care Inc. | Method and apparatus for providing leak detection in data monitoring and management systems |
| US7918978B2 (en) * | 2005-07-14 | 2011-04-05 | I-Stat Corporation | Photoformed silicone sensor membrane |
| US7766829B2 (en) | 2005-11-04 | 2010-08-03 | Abbott Diabetes Care Inc. | Method and system for providing basal profile modification in analyte monitoring and management systems |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| US7620438B2 (en) | 2006-03-31 | 2009-11-17 | Abbott Diabetes Care Inc. | Method and system for powering an electronic device |
| US8226891B2 (en) | 2006-03-31 | 2012-07-24 | Abbott Diabetes Care Inc. | Analyte monitoring devices and methods therefor |
| US20080071157A1 (en) | 2006-06-07 | 2008-03-20 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
| US8478377B2 (en) | 2006-10-04 | 2013-07-02 | Dexcom, Inc. | Analyte sensor |
| US8449464B2 (en) | 2006-10-04 | 2013-05-28 | Dexcom, Inc. | Analyte sensor |
| US8562528B2 (en) | 2006-10-04 | 2013-10-22 | Dexcom, Inc. | Analyte sensor |
| US8298142B2 (en) | 2006-10-04 | 2012-10-30 | Dexcom, Inc. | Analyte sensor |
| US8275438B2 (en) | 2006-10-04 | 2012-09-25 | Dexcom, Inc. | Analyte sensor |
| US8447376B2 (en) | 2006-10-04 | 2013-05-21 | Dexcom, Inc. | Analyte sensor |
| US20080128285A1 (en) * | 2006-12-04 | 2008-06-05 | Electronics And Telecommunications Research Institute | Electrochemical gas sensor chip and method of manufacturing the same |
| US8732188B2 (en) | 2007-02-18 | 2014-05-20 | Abbott Diabetes Care Inc. | Method and system for providing contextual based medication dosage determination |
| US8930203B2 (en) | 2007-02-18 | 2015-01-06 | Abbott Diabetes Care Inc. | Multi-function analyte test device and methods therefor |
| US8123686B2 (en) | 2007-03-01 | 2012-02-28 | Abbott Diabetes Care Inc. | Method and apparatus for providing rolling data in communication systems |
| US8383046B1 (en) * | 2007-04-16 | 2013-02-26 | Murthy Tata | Analyzer apparatus for measuring dissolved volatile substances and method |
| US8456301B2 (en) | 2007-05-08 | 2013-06-04 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
| US7928850B2 (en) | 2007-05-08 | 2011-04-19 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
| US8461985B2 (en) | 2007-05-08 | 2013-06-11 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
| US8665091B2 (en) | 2007-05-08 | 2014-03-04 | Abbott Diabetes Care Inc. | Method and device for determining elapsed sensor life |
| US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| CA2688184A1 (en) | 2007-06-08 | 2008-12-18 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| EP4159114B1 (en) | 2007-10-09 | 2024-04-10 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| EP2081018A1 (de) | 2008-01-18 | 2009-07-22 | F.Hoffmann-La Roche Ag | Gassensor mit mikroporöser Elektrolytschicht |
| US20090194416A1 (en) * | 2008-01-31 | 2009-08-06 | Chung Yuan Christian University | Potentiometric biosensor for detection of creatinine and forming method thereof |
| US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
| TWI448685B (zh) * | 2008-04-07 | 2014-08-11 | 私立中原大學 | 用於檢測肌酸酐濃度之電壓式生物感測器法及其形成方法 |
| TWI407099B (zh) * | 2008-08-01 | 2013-09-01 | 私立中原大學 | 電壓式生物感測器及其製作方法 |
| CN102272600A (zh) | 2008-12-31 | 2011-12-07 | 雅培医护站股份有限公司 | 用于使用核苷酸缀合物的免疫测定的方法和设备 |
| US8103456B2 (en) | 2009-01-29 | 2012-01-24 | Abbott Diabetes Care Inc. | Method and device for early signal attenuation detection using blood glucose measurements |
| US20100213057A1 (en) | 2009-02-26 | 2010-08-26 | Benjamin Feldman | Self-Powered Analyte Sensor |
| WO2010127050A1 (en) | 2009-04-28 | 2010-11-04 | Abbott Diabetes Care Inc. | Error detection in critical repeating data in a wireless sensor system |
| WO2010138856A1 (en) | 2009-05-29 | 2010-12-02 | Abbott Diabetes Care Inc. | Medical device antenna systems having external antenna configurations |
| WO2011026148A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods for managing power and noise |
| US9314195B2 (en) | 2009-08-31 | 2016-04-19 | Abbott Diabetes Care Inc. | Analyte signal processing device and methods |
| US9320461B2 (en) | 2009-09-29 | 2016-04-26 | Abbott Diabetes Care Inc. | Method and apparatus for providing notification function in analyte monitoring systems |
| JP5744906B2 (ja) | 2009-12-18 | 2015-07-08 | アボット ポイント オブ ケア インコーポレイテッド | 試料分析用の一体型ヒンジ式カートリッジ・ハウジング |
| EP2453228A1 (de) | 2010-11-10 | 2012-05-16 | F. Hoffmann-La Roche AG | Sauerstoffsensor mit mikroporöser Elektrolytschicht und teiloffener Deckmembran |
| ES2847578T3 (es) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Calibración avanzada de sensor de analito y detección de errores |
| AU2012335830B2 (en) | 2011-11-07 | 2017-05-04 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods |
| US9592507B2 (en) | 2012-06-22 | 2017-03-14 | Abbott Point Of Care Inc. | Integrated cartridge housings for sample analysis |
| US9038436B2 (en) * | 2012-07-30 | 2015-05-26 | Alcotek, Inc. | Fuel cell for use in an alcohol breath tester |
| US9968306B2 (en) | 2012-09-17 | 2018-05-15 | Abbott Diabetes Care Inc. | Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems |
| US8852877B2 (en) | 2012-12-28 | 2014-10-07 | Abbott Point Of Care Inc. | Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays |
| US9624532B2 (en) | 2013-02-05 | 2017-04-18 | Neil Gordon | Ultra-sensitive detection of extremely low level biological analytes using electrochemical signal amplification and biosensor |
| US9651547B2 (en) | 2013-03-14 | 2017-05-16 | Abbott Point Of Care Inc. | Electrochemical methods and devices for amending urine samples for immunosensor detection |
| US9488663B2 (en) | 2013-03-14 | 2016-11-08 | Abbott Point Of Care Inc. | Electrochemical methods and devices for amending urine samples for immunosensor detection |
| US10981172B2 (en) | 2013-03-14 | 2021-04-20 | Abbott Point Of Care Inc. | Thermal control system for controlling the temperature of a fluid |
| US9249450B2 (en) | 2013-03-15 | 2016-02-02 | Abbott Point Of Care Inc. | Glutamate oxidase mutagenesis for diagnostic testing |
| US9562874B2 (en) | 2013-03-15 | 2017-02-07 | Abbott Point Of Care Inc. | Biosensor with improved interference characteristics |
| US9487811B2 (en) | 2013-03-15 | 2016-11-08 | Abbott Point Of Care Inc. | Biosensor structures for improved point of care testing and methods of manufacture thereof |
| CN106662569B (zh) * | 2014-06-07 | 2020-02-28 | 艾西里昂公司 | 检测体液中的成分的微加工的传感器和方法 |
| EP3955003B1 (en) | 2014-09-26 | 2023-06-21 | Abbott Point Of Care Inc | Sensors for assaying coagulation in fluid samples |
| EP3198281B1 (en) | 2014-09-26 | 2023-01-25 | Abbott Point Of Care, Inc. | Ellagic acid formulations for use in coagulation assays |
| WO2016049533A1 (en) | 2014-09-26 | 2016-03-31 | Abbott Point Of Care Inc. | Cartridge device with fluidic junctions for coagulation assays in fluid samples |
| CN106999930B (zh) | 2014-09-26 | 2020-09-08 | 雅培医护站股份有限公司 | 用于测定流体样本中的凝结的具有分段射流的盒设备 |
| US10473612B2 (en) | 2014-09-26 | 2019-11-12 | Abbott Point Of Care Inc. | Cartridge device identification for coagulation assays in fluid samples |
| EP4043879A1 (en) | 2014-09-26 | 2022-08-17 | Abbott Point Of Care Inc | Single channel cartridge device for coagulation assays in fluid samples |
| ES2898200T3 (es) | 2014-09-26 | 2022-03-04 | Abbott Point Of Care Inc | Dispositivo microfabricado con sensores de microambiente para evaluar la coagulación en muestras de fluidos |
| WO2018191226A1 (en) * | 2017-04-10 | 2018-10-18 | Lifehealth, Llc | System for liberating and measuring nitric oxide |
| EP3928687B1 (en) | 2017-10-24 | 2024-06-26 | Dexcom, Inc. | Wearable device with pre-connected analyte sensor |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| CN112638532B (zh) | 2018-06-29 | 2023-08-11 | 雅培医护站股份有限公司 | 具有用于减轻流体样本漂移的旁路通道的盒装置 |
| US11260943B2 (en) * | 2019-01-09 | 2022-03-01 | California Institute Of Technology | Implantable micro-sensor to quantify dissolved inert gas |
| US12359279B2 (en) | 2019-03-20 | 2025-07-15 | Northwestern University | Conjugated polymers for the selective electroless recovery of gold and silver from solutions |
| US11408848B2 (en) | 2019-11-26 | 2022-08-09 | Nova Biomedical Corporation | Single-use disposable oxygen sensor |
| GB202316747D0 (en) * | 2023-11-01 | 2023-12-13 | Faradalc Sensors Gmbh | Gas sensor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5183549A (en) * | 1990-01-26 | 1993-02-02 | Commtech International Management Corporation | Multi-analyte sensing electrolytic cell |
| US5112455A (en) * | 1990-07-20 | 1992-05-12 | I Stat Corporation | Method for analytically utilizing microfabricated sensors during wet-up |
| US5246576A (en) * | 1990-12-10 | 1993-09-21 | Ppg Industries, Inc. | Cathode in a layered circuit and electrochemical cell for a measurement of oxygen in fluids |
| US5346604A (en) * | 1992-10-21 | 1994-09-13 | Diametrics Medical, Inc. | Self-activating chemical sensor system |
| US5387329A (en) * | 1993-04-09 | 1995-02-07 | Ciba Corning Diagnostics Corp. | Extended use planar sensors |
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1994
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1995
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- 1995-07-07 CA CA002194795A patent/CA2194795C/en not_active Expired - Lifetime
- 1995-07-07 DE DE69531961T patent/DE69531961T2/de not_active Expired - Lifetime
- 1995-07-07 EP EP95927432A patent/EP0805973B1/en not_active Expired - Lifetime
- 1995-07-07 WO PCT/US1995/009396 patent/WO1996002829A1/en active IP Right Grant
- 1995-07-07 JP JP08505283A patent/JP3093274B2/ja not_active Expired - Lifetime
- 1995-07-07 AT AT95927432T patent/ATE252233T1/de not_active IP Right Cessation
- 1995-07-07 KR KR1019970700143A patent/KR100359866B1/ko not_active Expired - Fee Related
Also Published As
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| AU3146795A (en) | 1996-02-16 |
| KR100316315B1 (ko) | 2002-07-02 |
| KR100359866B1 (ko) | 2003-04-10 |
| US5514253A (en) | 1996-05-07 |
| CA2194795A1 (en) | 1996-02-01 |
| AU689625B2 (en) | 1998-04-02 |
| EP0805973A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-11-12 |
| ATE252233T1 (de) | 2003-11-15 |
| JP3093274B2 (ja) | 2000-10-03 |
| DE69531961D1 (de) | 2003-11-20 |
| WO1996002829A1 (en) | 1996-02-01 |
| KR970705022A (ko) | 1997-09-06 |
| JPH10507515A (ja) | 1998-07-21 |
| EP0805973B1 (en) | 2003-10-15 |
| EP0805973A1 (en) | 1997-11-12 |
| DE69531961T2 (de) | 2004-07-22 |
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