CA2188258A1 - Sous unite de recepteur gamma 3 de gaba-a humain et lignees cellulaires co-transfectees de maniere stable - Google Patents
Sous unite de recepteur gamma 3 de gaba-a humain et lignees cellulaires co-transfectees de maniere stableInfo
- Publication number
- CA2188258A1 CA2188258A1 CA 2188258 CA2188258A CA2188258A1 CA 2188258 A1 CA2188258 A1 CA 2188258A1 CA 2188258 CA2188258 CA 2188258 CA 2188258 A CA2188258 A CA 2188258A CA 2188258 A1 CA2188258 A1 CA 2188258A1
- Authority
- CA
- Canada
- Prior art keywords
- subunit
- human
- leu
- receptor
- gabaa receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- MQGGXGKQSVEQHR-KKUMJFAQSA-N Tyr-Ser-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MQGGXGKQSVEQHR-KKUMJFAQSA-N 0.000 description 1
- PWKMJDQXKCENMF-MEYUZBJRSA-N Tyr-Thr-Leu Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O PWKMJDQXKCENMF-MEYUZBJRSA-N 0.000 description 1
- HMPMGPISLMLHSI-JBACZVJFSA-N Tyr-Trp-Gln Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)N HMPMGPISLMLHSI-JBACZVJFSA-N 0.000 description 1
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- AEOFMCAKYIQQFY-YDHLFZDLSA-N Tyr-Val-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 AEOFMCAKYIQQFY-YDHLFZDLSA-N 0.000 description 1
- PFMSJVIPEZMKSC-DZKIICNBSA-N Val-Tyr-Glu Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N PFMSJVIPEZMKSC-DZKIICNBSA-N 0.000 description 1
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- 239000003242 anti bacterial agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 108010013835 arginine glutamate Proteins 0.000 description 1
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- 108010038633 aspartylglutamate Proteins 0.000 description 1
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- 238000010804 cDNA synthesis Methods 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 description 1
- 108010050848 glycylleucine Proteins 0.000 description 1
- 108010077515 glycylproline Proteins 0.000 description 1
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- 238000011065 in-situ storage Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 108010049589 leucyl-leucyl-leucine Proteins 0.000 description 1
- 108010030617 leucyl-phenylalanyl-valine Proteins 0.000 description 1
- 108010057821 leucylproline Proteins 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 230000008488 polyadenylation Effects 0.000 description 1
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- 108010093296 prolyl-prolyl-alanine Proteins 0.000 description 1
- 108010031719 prolyl-serine Proteins 0.000 description 1
- 108010070643 prolylglutamic acid Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention se rapporte au clonage d'une nouvelle séquence d'ADN¿c? codant la sous-unité du récepteur .gamma.¿3? du récepteur de GABA¿A? humain, ainsi qu'à des lignées cellulaires eucaryotes co-transfectées de manière stable, susceptibles d'exprimer un récepteur de GABA¿A? humain, ce récepteur comprenant au moins une sous-unité de récepteur .alpha., au moins une sous-unité de récepteur .beta. et la sous-unité de récepteur .gamma.¿3?. L'invention se rapporte également à l'utilisation de ces lignées cellulaires dans la recherche par criblage et dans l'élaboration de médicaments agissant sur le récepteur de GABA¿A? humain.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9408064.5 | 1994-04-22 | ||
| GB9408064A GB9408064D0 (en) | 1994-04-22 | 1994-04-22 | Nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2188258A1 true CA2188258A1 (fr) | 1995-11-02 |
Family
ID=10753998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2188258 Abandoned CA2188258A1 (fr) | 1994-04-22 | 1995-04-12 | Sous unite de recepteur gamma 3 de gaba-a humain et lignees cellulaires co-transfectees de maniere stable |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0756626A1 (fr) |
| JP (1) | JPH10500007A (fr) |
| CA (1) | CA2188258A1 (fr) |
| GB (1) | GB9408064D0 (fr) |
| WO (1) | WO1995029234A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9603408D0 (sv) * | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
| GB9708479D0 (en) | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Nucleic acids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9112504D0 (en) * | 1991-06-11 | 1991-07-31 | Merck Sharp & Dohme | Cell line |
-
1994
- 1994-04-22 GB GB9408064A patent/GB9408064D0/en active Pending
-
1995
- 1995-04-12 WO PCT/GB1995/000834 patent/WO1995029234A1/fr not_active Application Discontinuation
- 1995-04-12 CA CA 2188258 patent/CA2188258A1/fr not_active Abandoned
- 1995-04-12 JP JP7527433A patent/JPH10500007A/ja active Pending
- 1995-04-12 EP EP95915245A patent/EP0756626A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995029234A1 (fr) | 1995-11-02 |
| JPH10500007A (ja) | 1998-01-06 |
| EP0756626A1 (fr) | 1997-02-05 |
| GB9408064D0 (en) | 1994-06-15 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |