CA2186987A1 - Inhibiteurs de glcnac-t et leur emploi pour prevenir ou traiter la cardiomyopathie associee au diabete - Google Patents
Inhibiteurs de glcnac-t et leur emploi pour prevenir ou traiter la cardiomyopathie associee au diabeteInfo
- Publication number
- CA2186987A1 CA2186987A1 CA002186987A CA2186987A CA2186987A1 CA 2186987 A1 CA2186987 A1 CA 2186987A1 CA 002186987 A CA002186987 A CA 002186987A CA 2186987 A CA2186987 A CA 2186987A CA 2186987 A1 CA2186987 A1 CA 2186987A1
- Authority
- CA
- Canada
- Prior art keywords
- core
- glcnac
- g1cnac
- substance
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002186987A CA2186987A1 (fr) | 1996-10-02 | 1996-10-02 | Inhibiteurs de glcnac-t et leur emploi pour prevenir ou traiter la cardiomyopathie associee au diabete |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002186987A CA2186987A1 (fr) | 1996-10-02 | 1996-10-02 | Inhibiteurs de glcnac-t et leur emploi pour prevenir ou traiter la cardiomyopathie associee au diabete |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2186987A1 true CA2186987A1 (fr) | 1998-04-02 |
Family
ID=4159008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002186987A Abandoned CA2186987A1 (fr) | 1996-10-02 | 1996-10-02 | Inhibiteurs de glcnac-t et leur emploi pour prevenir ou traiter la cardiomyopathie associee au diabete |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2186987A1 (fr) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1131334A1 (fr) * | 1998-11-21 | 2001-09-12 | The Regents of the University of California | Utilisation d'inhibiteurs de 2 glcnac transferase centrale dans le traitement d'inflammation |
| WO2005060977A1 (fr) * | 2003-12-22 | 2005-07-07 | Btg International Limited | Inhibiteurs de la glcnac-t de structure noyau 2 |
| US7256171B1 (en) | 1999-11-20 | 2007-08-14 | The Regents Of The University Of California | Use of core 2 G1cNAc transferase inhibitors in treating inflammation |
| US7811781B2 (en) | 2005-07-06 | 2010-10-12 | Btg International Limited | Core 2 β(1,6)-acetylglycosaminyltransferase as diagnostic marker for atherosclerosis |
| US7998943B2 (en) | 2005-07-06 | 2011-08-16 | Btg International Limited | Core 2 GlcNAc-T inhibitors III |
| US8197794B2 (en) | 2003-12-22 | 2012-06-12 | Ms Therapeutics Limited | Core 2 GlcNAc-T inhibitors |
| US8609633B2 (en) | 2005-07-06 | 2013-12-17 | Ms Therapeutics Limited | Core 2 GlcNAc-T inhibitors |
| US20140228313A1 (en) * | 2005-01-14 | 2014-08-14 | The Regents Of The University Of California | Methods and compositions for preventing and treating a disease related to glycan dysregulation |
-
1996
- 1996-10-02 CA CA002186987A patent/CA2186987A1/fr not_active Abandoned
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1131334A1 (fr) * | 1998-11-21 | 2001-09-12 | The Regents of the University of California | Utilisation d'inhibiteurs de 2 glcnac transferase centrale dans le traitement d'inflammation |
| EP1131334A4 (fr) * | 1998-11-21 | 2003-05-21 | Univ California | Utilisation d'inhibiteurs de 2 glcnac transferase centrale dans le traitement d'inflammation |
| US7256171B1 (en) | 1999-11-20 | 2007-08-14 | The Regents Of The University Of California | Use of core 2 G1cNAc transferase inhibitors in treating inflammation |
| WO2005060977A1 (fr) * | 2003-12-22 | 2005-07-07 | Btg International Limited | Inhibiteurs de la glcnac-t de structure noyau 2 |
| JP2007515466A (ja) * | 2003-12-22 | 2007-06-14 | ビーティージー・インターナショナル・リミテッド | コア２ＧｌｃＮＡｃ−Ｔ阻害剤 |
| US7906493B2 (en) | 2003-12-22 | 2011-03-15 | Btg International Limited | Core 2 GlcNAc-T inhibitors |
| US8197794B2 (en) | 2003-12-22 | 2012-06-12 | Ms Therapeutics Limited | Core 2 GlcNAc-T inhibitors |
| US20140228313A1 (en) * | 2005-01-14 | 2014-08-14 | The Regents Of The University Of California | Methods and compositions for preventing and treating a disease related to glycan dysregulation |
| US9775859B2 (en) * | 2005-01-14 | 2017-10-03 | Sinai Health System | Methods and compositions for preventing and treating a disease related to glycan dysregulation |
| US7811781B2 (en) | 2005-07-06 | 2010-10-12 | Btg International Limited | Core 2 β(1,6)-acetylglycosaminyltransferase as diagnostic marker for atherosclerosis |
| US7998943B2 (en) | 2005-07-06 | 2011-08-16 | Btg International Limited | Core 2 GlcNAc-T inhibitors III |
| US8609633B2 (en) | 2005-07-06 | 2013-12-17 | Ms Therapeutics Limited | Core 2 GlcNAc-T inhibitors |
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