CA2179288A1 - Analogues de vitamines d3 et voie induisant des troubles - Google Patents
Analogues de vitamines d3 et voie induisant des troublesInfo
- Publication number
- CA2179288A1 CA2179288A1 CA002179288A CA2179288A CA2179288A1 CA 2179288 A1 CA2179288 A1 CA 2179288A1 CA 002179288 A CA002179288 A CA 002179288A CA 2179288 A CA2179288 A CA 2179288A CA 2179288 A1 CA2179288 A1 CA 2179288A1
- Authority
- CA
- Canada
- Prior art keywords
- vitamin
- analog
- alpha
- analogues
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procédés de régulation de réponses cellulaires génomiques et non génomiques induites par 1.alpha.,25-(OH)¿2? vitamine D¿3?[1.alpha.,25-(OH)¿2?D¿3?]. Le procédé consiste à traiter des cellules présentant des réponses non génomiques à 1.alpha.,25-(OH)¿2?D¿3? à l'aide des analogues de vitamine D¿3? 1,25(OH)¿2?-provitamine D¿3? ou 1.beta.,25-(OH)¿2? vitamine D¿3? [1.beta.,25-OH)¿2?D¿3?]. La 1,25(OH)¿2?-provitamine D¿3? fait office d'agoniste stimulant la réponse cellulaire tandis que la 1.beta.,25-(OH)¿2?D¿3? fait office d'antagoniste. La transcaltachia est une des réponses non génomique affectée et pouvant être régulée par administration de 1,25(OH)¿2?-provitamine D¿3? ou 1.beta.,25-(OH)¿2?D¿3?. L'invention concerne également quinze autres analogues que l'on peut utiliser pour réguler des réponses cellulaires génomiques et/ou non génomiques.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17356193A | 1993-12-23 | 1993-12-23 | |
US24938594A | 1994-05-25 | 1994-05-25 | |
US08/249,385 | 1994-05-25 | ||
US08/173,561 | 1994-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2179288A1 true CA2179288A1 (fr) | 1995-06-29 |
Family
ID=26869286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002179288A Abandoned CA2179288A1 (fr) | 1993-12-23 | 1994-12-23 | Analogues de vitamines d3 et voie induisant des troubles |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0737070A4 (fr) |
JP (1) | JPH09507079A (fr) |
AU (1) | AU1445295A (fr) |
CA (1) | CA2179288A1 (fr) |
WO (1) | WO1995017197A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA26481A1 (fr) * | 1997-04-21 | 2004-12-20 | Hoffmann La Roche | Derives d'arylsecocholadiene |
WO1998051663A2 (fr) * | 1997-05-16 | 1998-11-19 | F. Hoffmann-La Roche Ag | Composes 3-epi de vitamine d3 et leurs utilisations |
EP1891944A1 (fr) | 2006-07-24 | 2008-02-27 | Association pour la recherche à l'IGBMC (ARI) | Utilisation d'une agoniste de Vitamin D3 dans une modele mammifere pour la maladie atopique et utlisation d'une antagoniste de Vitamin D3 dans le traitement de la maladie atopique |
EP4081221A1 (fr) * | 2019-08-22 | 2022-11-02 | Industrial Technologies & Biotechnologies | Hormone d (vitamine d) et ses dérivés pour le traitement et la prévention du cancer |
CN111830157B (zh) * | 2020-07-17 | 2022-02-25 | 大连美创药业有限公司 | 一种合成艾地骨化醇中间体的气相色谱检测方法 |
CN115850142A (zh) * | 2022-11-25 | 2023-03-28 | 甘肃皓天医药科技有限责任公司 | 一种7z维生素d类化合物的合成方法 |
-
1994
- 1994-12-23 JP JP7517631A patent/JPH09507079A/ja not_active Ceased
- 1994-12-23 CA CA002179288A patent/CA2179288A1/fr not_active Abandoned
- 1994-12-23 EP EP95906111A patent/EP0737070A4/fr not_active Withdrawn
- 1994-12-23 AU AU14452/95A patent/AU1445295A/en not_active Abandoned
- 1994-12-23 WO PCT/US1994/014870 patent/WO1995017197A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1995017197A1 (fr) | 1995-06-29 |
EP0737070A4 (fr) | 1999-03-17 |
EP0737070A1 (fr) | 1996-10-16 |
JPH09507079A (ja) | 1997-07-15 |
AU1445295A (en) | 1995-07-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2126384C1 (ru) | Аналоги витамина д, способ их получения, промежуточное соединение, фармацевтическая композиция, способ подавления болезненных состояний | |
Minghetti et al. | 1, 25 (OH) 2‐vitamin D3 receptors: gene regulation and genetic circuitry | |
CN100438877C (zh) | (20S)-1α-羟基-2α-甲基和2β-甲基-19-去甲-维生素D3及它们的用途 | |
Mather et al. | The growth of mouse melanoma cells in hormone-supplemented, serum-free medium | |
Norman et al. | Structure-function studies on analogues of 1α, 25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption | |
Norman et al. | Structure-function studies of 1, 25-dihydroxyvitamin D3 and the vitamin D endocrine system. 1, 25-dihydroxy-pentadeuterio-previtamin D3 (as a 6-s-cis analog) stimulates nongenomic but not genomic biological responses | |
AU2005309805B2 (en) | 17,20(Z)-dehydro vitamin D analogs and their uses | |
Simonian et al. | Characterization of cultured bovine adrenocortical cells and derived clonal lines: regulation of steroidogenesis and culture life span | |
Qaw et al. | In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1 alpha, 25-and 1 beta, 25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity. | |
JP6383365B2 (ja) | (22E)−2−メチレン−22−デヒドロ−1α,24,25−トリヒドロキシ−19−ノル−ビタミンD3類似体 | |
DE68904235T2 (de) | Vitamin d-derivate : anwendung in der therapie und zur quantitativen bestimmung der vitamin d-metaboliten. | |
US6121469A (en) | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs | |
Cancela et al. | 1α, 25 (OH) 2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms | |
KR100399661B1 (ko) | 비타민d및아마이드유도체 | |
Okamura et al. | Studies on vitamin D and its analogs. VIII. 3-deoxy-1α, 25-dihydroxyvitamin D3, a potent new analog of 1α, 25-(OH) 2-D3 | |
CA2179288A1 (fr) | Analogues de vitamines d3 et voie induisant des troubles | |
Maynard et al. | 14-epi stereoisomers of 25-hydroxy-and 1. Alpha., 25-dihydroxyvitamin d3: Synthesis, isomerization to previtamins, and biological studies | |
Posner et al. | 2, 2-Disubstituted analogues of the natural hormone 1α, 25-dihydroxyvitamin D3: chemistry and biology | |
AU2009268557B2 (en) | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs | |
Siu-Caldera et al. | 1α, 25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1α, 25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells | |
MXPA06000063A (es) | (20s)-1alfa-hydroxi-2-metilen-19-nor-vitamina d3 y sus usos. | |
Napoli et al. | Synthesis and biological activity of 24-hydroxy-25-fluorovitamin D3. A highly potent mediator of calcium metabolism. | |
Anderson et al. | Stable isotope studies on steroid metabolism and kinetics: sulfates of 3α-hydroxy-5α-pregnane derivatives in human pregnancy | |
CA2334347C (fr) | Analogues 24,24-fluores de 1-alpha,25-dihydroxy vitamine d3 | |
Farrell et al. | Isolation of desoxycorticosterone from adrenal venous blood of the dog; effect of hypophysectomy and ACTH. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |