CA2176461C - Procede de preparation de produits pharmaceutiques a faible dosage - Google Patents

Procede de preparation de produits pharmaceutiques a faible dosage Download PDF

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Publication number
CA2176461C
CA2176461C CA002176461A CA2176461A CA2176461C CA 2176461 C CA2176461 C CA 2176461C CA 002176461 A CA002176461 A CA 002176461A CA 2176461 A CA2176461 A CA 2176461A CA 2176461 C CA2176461 C CA 2176461C
Authority
CA
Canada
Prior art keywords
composition
surfactant
pharmaceutically acceptable
aqueous medium
granulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002176461A
Other languages
English (en)
Other versions
CA2176461A1 (fr
Inventor
Frank C. Greaves
James Swarbrick
Martin W. Beasley
Andrew W. Suddith
Henry C. Caldwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Barr Pharmaceuticals Inc
Original Assignee
Barr Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ZA939565A external-priority patent/ZA939565B/xx
Application filed by Barr Laboratories Inc filed Critical Barr Laboratories Inc
Publication of CA2176461A1 publication Critical patent/CA2176461A1/fr
Application granted granted Critical
Publication of CA2176461C publication Critical patent/CA2176461C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé par voie humide utilisé pour préparer une composition pharmaceutique solide destinée à l'administration par voie orale de médicaments à faible dosage dont les principes actifs présentent des structures stéroïdiennes ou de type stéroïdien. Ce procédé consiste à mettre en suspension des médicaments ayant une faible solubilité, dans une solution aqueuse de liant contenant des traces d'un tensioactif. On mélange ensuite cette suspension aqueuse à des charges de remplissage et on les met sous forme de granules. Les granules déshydratés peuvent être ensuite transformés en capsules, comprimés, pastilles, tablettes, produits ou suspensions à libération prolongée ou retardée.
CA002176461A 1993-12-21 1994-12-20 Procede de preparation de produits pharmaceutiques a faible dosage Expired - Lifetime CA2176461C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA939565A ZA939565B (en) 1993-12-21 1993-12-21 Method for preparing low dose pharmaceutical products.
ZA93/9565 1993-12-21
PCT/US1994/014638 WO1995017168A1 (fr) 1993-12-21 1994-12-20 Procede de preparation de produits pharmaceutiques a faible dosage

Publications (2)

Publication Number Publication Date
CA2176461A1 CA2176461A1 (fr) 1995-06-29
CA2176461C true CA2176461C (fr) 2007-03-13

Family

ID=38007970

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002176461A Expired - Lifetime CA2176461C (fr) 1993-12-21 1994-12-20 Procede de preparation de produits pharmaceutiques a faible dosage

Country Status (1)

Country Link
CA (1) CA2176461C (fr)

Also Published As

Publication number Publication date
CA2176461A1 (fr) 1995-06-29

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Effective date: 20141222