CA2176460C - Procede de compression d'un melange sec de medicaments - Google Patents

Procede de compression d'un melange sec de medicaments Download PDF

Info

Publication number
CA2176460C
CA2176460C CA002176460A CA2176460A CA2176460C CA 2176460 C CA2176460 C CA 2176460C CA 002176460 A CA002176460 A CA 002176460A CA 2176460 A CA2176460 A CA 2176460A CA 2176460 C CA2176460 C CA 2176460C
Authority
CA
Canada
Prior art keywords
group
composition
excipient
estrogen
agglomerated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002176460A
Other languages
English (en)
Other versions
CA2176460A1 (fr
Inventor
Frank C. Greaves
James Swarbrick
Martin W. Beasley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Barr Pharmaceuticals Inc
Original Assignee
Barr Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ZA939566A external-priority patent/ZA939566B/xx
Application filed by Barr Laboratories Inc filed Critical Barr Laboratories Inc
Publication of CA2176460A1 publication Critical patent/CA2176460A1/fr
Application granted granted Critical
Publication of CA2176460C publication Critical patent/CA2176460C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Procédé de compression d'un mélange sec de substances médicamenteuses puissantes présentant une faible solubilité, telles que des médicaments stéroïdiens, à l'aide d'excipients agglomérés pouvant être compressés directement, ces excipients n'étant pas un polyalcool ou un lactose classique ou séché par pulvérisation. Lesdits excipients agglomérés peuvent être du mannitol, de la malto-dextrine ou du sirop de maïs déshydraté, et servent à retenir le(s) médicament(s) dans les fissures des agglomérats. Cette invention décrit également les rapports critiques excipients agglomérés/agents stéroïdiens, notamment l'oestradil, qui est réparti uniformément dans le mélange sec puis compressé sous forme de comprimés.
CA002176460A 1993-12-21 1994-12-20 Procede de compression d'un melange sec de medicaments Expired - Lifetime CA2176460C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA93/9566 1993-12-21
ZA939566A ZA939566B (en) 1993-12-21 1993-12-21 Method for dry blend compression od medicaments.
PCT/US1994/014639 WO1995017169A1 (fr) 1993-12-21 1994-12-20 Procede de compression d'un melange sec de medicaments

Publications (2)

Publication Number Publication Date
CA2176460A1 CA2176460A1 (fr) 1995-06-29
CA2176460C true CA2176460C (fr) 2007-03-13

Family

ID=38007968

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002176460A Expired - Lifetime CA2176460C (fr) 1993-12-21 1994-12-20 Procede de compression d'un melange sec de medicaments

Country Status (1)

Country Link
CA (1) CA2176460C (fr)

Also Published As

Publication number Publication date
CA2176460A1 (fr) 1995-06-29

Similar Documents

Publication Publication Date Title
FI100770B (fi) Menetelmä pieniannoksisten kuivien farmaseuttisten valmisteiden valmis tamiseksi
AU700645B2 (en) Process of making dosage units by wet granulation
US5395627A (en) Pharmaceutical granulate
US5976570A (en) Method for preparing low dose pharmaceutical products
US5928668A (en) Method for dry blend compression of medicaments
EP0735862B1 (fr) Procede de compression d'un melange sec de medicaments
EP0735864B1 (fr) Procede de preparation de produits pharmaceutiques a faible dosage
CA2176460C (fr) Procede de compression d'un melange sec de medicaments
CA2176461C (fr) Procede de preparation de produits pharmaceutiques a faible dosage
US20050181040A1 (en) Progestagenic dosage unit
KR100349230B1 (ko) 약제용과립및그제조방법

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20141222