CA2167538A1 - Stabilisation de proteines aerosols - Google Patents
Stabilisation de proteines aerosolsInfo
- Publication number
- CA2167538A1 CA2167538A1 CA 2167538 CA2167538A CA2167538A1 CA 2167538 A1 CA2167538 A1 CA 2167538A1 CA 2167538 CA2167538 CA 2167538 CA 2167538 A CA2167538 A CA 2167538A CA 2167538 A1 CA2167538 A1 CA 2167538A1
- Authority
- CA
- Canada
- Prior art keywords
- protein
- aqueous solution
- peg
- aerosolized
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Colloid Chemistry (AREA)
Abstract
Procédé de protection de protéines contre la dégradation due à la pulvérisation sous forme d'aérosol et la perte de leur activité protéique. On stabilise les protéines comprises dans l'aérosol en ajoutant à la solution aqueuse, avant sa pulvérisation, un composé polaire organique hydrosoluble, par exemple le polyéthylène-glycol, ou un tensioactif. On a également prévu une solution aqueuse de protéines stabilisées renfermant un composé polaire organique ou un tensioactif, ainsi qu'un système de pulvérisation sous forme d'aérosol de la solution aqueuse renfermant les protéines stabilisées.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9384093A | 1993-07-19 | 1993-07-19 | |
US08/093,840 | 1993-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2167538A1 true CA2167538A1 (fr) | 1995-02-02 |
Family
ID=22241106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2167538 Abandoned CA2167538A1 (fr) | 1993-07-19 | 1994-07-19 | Stabilisation de proteines aerosols |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0710102A1 (fr) |
JP (1) | JPH09501418A (fr) |
AU (1) | AU691514B2 (fr) |
CA (1) | CA2167538A1 (fr) |
FI (1) | FI960253A (fr) |
NO (1) | NO960217L (fr) |
NZ (1) | NZ271181A (fr) |
WO (1) | WO1995003034A1 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030113271A1 (en) * | 1997-01-29 | 2003-06-19 | University Technology Corporation | Formulations for pulmonary delivery |
DE19733651A1 (de) * | 1997-08-04 | 1999-02-18 | Boehringer Ingelheim Pharma | Wässrige Aerosolzubereitungen enthaltend biologisch aktive Markomoleküle und Verfahren zur Erzeugung entsprechender Aerosole |
SK11142002A3 (sk) * | 1999-12-30 | 2004-09-08 | Chiron Corporation | Liečivo na podávanie interleukínu-2 a stabilizovaný lyofilizovaný alebo sprejovo sušený farmaceutický prostriedok s obsahom interleukínu-2 |
DE60103940T2 (de) | 2000-02-29 | 2005-07-28 | Pfizer Products Inc., Groton | Stabilisierter Granulozyten-Kolonie-stimulierender Faktor |
NZ548578A (en) | 2001-02-02 | 2008-03-28 | Ortho Mcneil Pharm Inc | Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin |
US20030072717A1 (en) | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
ES2268044T3 (es) * | 2001-05-21 | 2007-03-16 | Injet Digital Aerosols Limited | Composiciones para la administracion de proteinas por la via pulmonar. |
JP2004087560A (ja) | 2002-08-23 | 2004-03-18 | Sansha Electric Mfg Co Ltd | 電源装置 |
TW200938222A (en) * | 2007-12-13 | 2009-09-16 | Glaxo Group Ltd | Compositions for pulmonary delivery |
EP2077132A1 (fr) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispositif distributeur, dispositif de stockage et procédé pour la distribution d'une formulation |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
EP3508239B1 (fr) | 2009-05-18 | 2020-12-23 | Boehringer Ingelheim International GmbH | Adaptateur, dispositif d'inhalation et pulvérisateur |
WO2011064163A1 (fr) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nébuliseur |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
UA107097C2 (en) | 2009-11-25 | 2014-11-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Dispenser |
JP5874724B2 (ja) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
EP2694220B1 (fr) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Appareil médical pourvu d'un récipient |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
BR112014002593B1 (pt) | 2011-08-02 | 2022-11-29 | Alfasigma S.p.A | Composição farmacêutica de avidina oxidada apropriada para inalação e kits relacionados |
WO2013152894A1 (fr) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Pulvérisateur comprenant des moyens de détrompage |
ES2836977T3 (es) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizador |
EP3030298B1 (fr) | 2013-08-09 | 2017-10-11 | Boehringer Ingelheim International GmbH | Nébuliseur |
UA121114C2 (uk) | 2014-05-07 | 2020-04-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Небулайзер, індикаторний пристрій і контейнер |
ES2874029T3 (es) | 2014-05-07 | 2021-11-04 | Boehringer Ingelheim Int | Nebulizador |
ES2954961T3 (es) | 2014-05-07 | 2023-11-27 | Boehringer Ingelheim Int | Unidad, nebulizador y método |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4897256A (en) * | 1986-11-25 | 1990-01-30 | Abbott Laboratories | LHRH analog formulations |
GB8921222D0 (en) * | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
RU2054180C1 (ru) * | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
-
1994
- 1994-07-19 WO PCT/US1994/008136 patent/WO1995003034A1/fr not_active Application Discontinuation
- 1994-07-19 AU AU74732/94A patent/AU691514B2/en not_active Ceased
- 1994-07-19 NZ NZ271181A patent/NZ271181A/en unknown
- 1994-07-19 CA CA 2167538 patent/CA2167538A1/fr not_active Abandoned
- 1994-07-19 JP JP7505271A patent/JPH09501418A/ja active Pending
- 1994-07-19 EP EP94924473A patent/EP0710102A1/fr not_active Withdrawn
-
1996
- 1996-01-18 FI FI960253A patent/FI960253A/fi unknown
- 1996-01-18 NO NO960217A patent/NO960217L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI960253A (fi) | 1996-03-18 |
NZ271181A (en) | 1998-06-26 |
NO960217L (no) | 1996-03-18 |
AU7473294A (en) | 1995-02-20 |
EP0710102A1 (fr) | 1996-05-08 |
JPH09501418A (ja) | 1997-02-10 |
WO1995003034A1 (fr) | 1995-02-02 |
AU691514B2 (en) | 1998-05-21 |
FI960253A0 (fi) | 1996-01-18 |
NO960217D0 (no) | 1996-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |