CA2161971A1 - Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof - Google Patents

Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof

Info

Publication number
CA2161971A1
CA2161971A1 CA002161971A CA2161971A CA2161971A1 CA 2161971 A1 CA2161971 A1 CA 2161971A1 CA 002161971 A CA002161971 A CA 002161971A CA 2161971 A CA2161971 A CA 2161971A CA 2161971 A1 CA2161971 A1 CA 2161971A1
Authority
CA
Canada
Prior art keywords
bpi
lbp
chimera
variant
lps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002161971A
Other languages
English (en)
French (fr)
Inventor
Randal W. Scott
Marian N. Marra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2161971A1 publication Critical patent/CA2161971A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002161971A 1993-04-30 1994-04-29 Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof Abandoned CA2161971A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5629293A 1993-04-30 1993-04-30
US16571793A 1993-12-10 1993-12-10
US08/165,717 1993-12-10
US08/056,292 1993-12-10
PCT/US1994/004709 WO1994025476A1 (en) 1993-04-30 1994-04-29 Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof

Publications (1)

Publication Number Publication Date
CA2161971A1 true CA2161971A1 (en) 1994-11-10

Family

ID=26735192

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002161971A Abandoned CA2161971A1 (en) 1993-04-30 1994-04-29 Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof

Country Status (5)

Country Link
EP (1) EP0760849A1 (ja)
JP (1) JPH08511682A (ja)
AU (1) AU6942994A (ja)
CA (1) CA2161971A1 (ja)
WO (1) WO1994025476A1 (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265187B1 (en) * 1989-02-14 2001-07-24 Incyte Pharmaceuticals, Inc. Recombinant endotoxin-neutralizing proteins
US5420019A (en) * 1993-02-02 1995-05-30 Xoma Corporation Stable bactericidal/permeability-increasing protein muteins
US5652332A (en) * 1993-03-12 1997-07-29 Xoma Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5484705A (en) * 1994-01-24 1996-01-16 Xoma Corporation Method for quantifying lipopolysaccharide binding protein
US5891618A (en) 1994-01-24 1999-04-06 Xoma Corporation Method for quantifying LBP in body fluids
US5786324A (en) * 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5830860A (en) * 1994-03-24 1998-11-03 Regents Of The University Of Minnesota Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
EP0839156A1 (en) * 1995-07-20 1998-05-06 Xoma Corporation Anti-fungal peptides
US5780429A (en) * 1995-12-22 1998-07-14 Marine Biological Laboratory Anti-LPS factor from horseshoe crabs and methods of use
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
ATE198050T1 (de) 1996-05-10 2000-12-15 Xoma Technology Ltd Therapeutische anwendungen von bpi-protein- produkten zur behandlung von humaner meningococcämia
JP2000511190A (ja) * 1996-05-23 2000-08-29 ゾーマ コーポレイション 外傷に起因する出血に見舞われたヒトにおけるｂｐｉタンパク質産物の治療用途
WO1997044354A2 (en) 1996-05-24 1997-11-27 Regents Of The University Of Minnesota Synthesis of soluble beta-sheet forming peptides
US5888973A (en) 1996-08-09 1999-03-30 Xoma Corporation Anti-chlamydial uses of BPI protein products
US6482796B2 (en) 1996-11-01 2002-11-19 Xoma Corporation Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US5846789A (en) * 1996-12-10 1998-12-08 Council Of Scientific And Industrial Research Process for preparing nontoxic lipopolysaccharides from acidiphilium species
US6093573A (en) * 1997-06-20 2000-07-25 Xoma Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
DE19729810C2 (de) * 1997-07-11 2000-01-13 Max Delbrueck Centrum Mittel zur Sepsistherapie, seine Herstellung und seine Verwendung
US5990082A (en) * 1997-10-22 1999-11-23 Xoma Corporation Uses of lipopolysaccharide binding protein
US6013631A (en) 1998-06-19 2000-01-11 Xoma Corporation Bactericidal/permeability-increasing protein (BPI) deletion analogs
EP1572719A4 (en) 2002-02-20 2007-11-14 Univ Minnesota PARTIAL PEPTIDE MIMETICS AND METHOD
US8703134B2 (en) 2003-05-15 2014-04-22 Iogenetics, Llc Targeted cryptosporidium biocides
US8394379B2 (en) 2003-05-15 2013-03-12 Iogenetics, Llc Targeted cryptosporidium biocides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234912A (en) * 1989-02-14 1993-08-10 Incyte Pharmaceuticals, Inc. Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
US5089274A (en) * 1989-02-14 1992-02-18 Incyte Pharmaceuticals, Inc. Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
US5171739A (en) * 1989-02-14 1992-12-15 Incyte Pharmaceuticals, Inc. Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
ES2120949T4 (es) * 1990-06-28 2011-12-29 Sanofi-Aventis Deutschland Gmbh 50% Proteinas de fusión con porciones de inmunoglobulinas, su preparación y empleo.
AU2872792A (en) * 1991-09-26 1993-04-27 Incyte Pharmaceuticals, Inc. A new form of liposaccharide binding protein (lbp)
US5643570A (en) * 1992-05-19 1997-07-01 Xoma Corporation BPI-immunoglobulin fusion proteins

Also Published As

Publication number Publication date
WO1994025476A1 (en) 1994-11-10
EP0760849A4 (en) 1996-12-02
AU6942994A (en) 1994-11-21
EP0760849A1 (en) 1997-03-12
JPH08511682A (ja) 1996-12-10

Similar Documents

Publication Publication Date Title
CA2161971A1 (en) Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof
JP3493022B2 (ja) 組換えｂｐｉタンパク、ｂｐｉタンパクの使用および該タンパクの製造方法
Borregaard et al. Stimulus-dependent secretion of plasma proteins from human neutrophils.
EP1246846B1 (en) Soluble interleukin-20 receptor
EP1379266B1 (en) Modified annexin proteins and prevention and treatment of thrombosis
EP0610445B1 (en) Use of compositions comprising a bactericidal/permeability increasing protein and a lipid carrier
US7387780B2 (en) Soluble interleukin-20 receptor
JP2003514852A (ja) 炎症反応を阻害する細胞透過性ペプチドおよび使用方法
KR20150121715A (ko) Ｃｓｆ１ 치료제
US20060093614A1 (en) Platelet glycoprotein Ib alpha fusion polypeptides and methods of use thereof
JPH11500308A (ja) 新規ｃ−ＭＰＬリガンド
MXPA06003695A (es) Usos terapeuticos de variantes de quimiocinas.
JPH09500269A (ja) 殺菌性／透過性が増大したグリコシル化及び非グリコシル化タンパク質及びその製造方法
US6265187B1 (en) Recombinant endotoxin-neutralizing proteins
WO1993019772A1 (en) A novel therapy for treating sepsis using a soluble form of recombinant cd14 myelomonocytic antigen
JPH05501503A (ja) 多量体ゲルゾリン融合構築物
KR100260272B1 (ko) Tpo활성을 갖는 단백질의 아미노산을 코딩하는 염기 서열을 포함하는 dna
AU2003233008A1 (en) Fusion polypeptides and methods for inhibiting microbial adhesion

Legal Events

Date Code Title Description
FZDE Discontinued