CA2153419A1 - Novel taxoids, preparation thereof and pharmaceutical compositions containing same - Google Patents

Novel taxoids, preparation thereof and pharmaceutical compositions containing same

Info

Publication number
CA2153419A1
CA2153419A1 CA002153419A CA2153419A CA2153419A1 CA 2153419 A1 CA2153419 A1 CA 2153419A1 CA 002153419 A CA002153419 A CA 002153419A CA 2153419 A CA2153419 A CA 2153419A CA 2153419 A1 CA2153419 A1 CA 2153419A1
Authority
CA
Canada
Prior art keywords
radical
preparation
pharmaceutical compositions
compositions containing
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002153419A
Other languages
French (fr)
Other versions
CA2153419C (en
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Jean-Pierre Pulicani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Jean-Pierre Pulicani
Rhone-Poulenc Rorer S.A.
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9302370A external-priority patent/FR2702212B1/en
Application filed by Herve Bouchard, Jean-Dominique Bourzat, Alain Commercon, Jean-Pierre Pulicani, Rhone-Poulenc Rorer S.A., Aventis Pharma S.A. filed Critical Herve Bouchard
Publication of CA2153419A1 publication Critical patent/CA2153419A1/en
Application granted granted Critical
Publication of CA2153419C publication Critical patent/CA2153419C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveaux taxoïdes de formule générale (I), leur préparation et les compositions pharmaceutiques qui les contiennent. Dans la formule générale (I), Ar représente un radical aryle, R représente un atome d'hydrogène ou un radical acétyle ou alcoxyacétyle, R1 représente un radical benzoyle ou un radical R2-O-CO- dans lequel R2 représente un radical alcoyle, alcényle, cycloalcoyle, cycloalcényle, bicycloalcyle, phényle ou hétérocyclyle et R3 représente un radical alcoyle, alcényle, cycloalcoyle, cycloalcényle, bicycloalcoyle, aryle éventuellement substitué (à l'exception de phényle non substitué) ou hétéroyclyle. Les produits de formule générale (I) présentent des propriétés antitumorales remarquables.New taxoids of general formula (I), their preparation and the pharmaceutical compositions containing them. In the general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl or alkoxyacetyl radical, R1 represents a benzoyl radical or an R2-O-CO- radical in which R2 represents an alkyl radical, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl and R3 represents an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted aryl (except for unsubstituted phenyl) or heteroyclyl radical. The products of general formula (I) have remarkable anti-tumor properties.

CA002153419A 1993-03-02 1994-02-28 Novel taxoids, preparation thereof and pharmaceutical compositions containing same Expired - Lifetime CA2153419C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR93/02370 1993-03-02
FR9302370A FR2702212B1 (en) 1993-03-02 1993-03-02 New taxoids, their preparation and the pharmaceutical compositions containing them.
PCT/FR1994/000222 WO1994020484A1 (en) 1993-03-02 1994-02-28 Novel taxoids, preparation thereof and pharmaceutical compositions containing same

Publications (2)

Publication Number Publication Date
CA2153419A1 true CA2153419A1 (en) 1994-09-15
CA2153419C CA2153419C (en) 2007-01-02

Family

ID=37603318

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002153419A Expired - Lifetime CA2153419C (en) 1993-03-02 1994-02-28 Novel taxoids, preparation thereof and pharmaceutical compositions containing same

Country Status (1)

Country Link
CA (1) CA2153419C (en)

Also Published As

Publication number Publication date
CA2153419C (en) 2007-01-02

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Effective date: 20140228