CA2153419A1 - Novel taxoids, preparation thereof and pharmaceutical compositions containing same - Google Patents
Novel taxoids, preparation thereof and pharmaceutical compositions containing sameInfo
- Publication number
- CA2153419A1 CA2153419A1 CA002153419A CA2153419A CA2153419A1 CA 2153419 A1 CA2153419 A1 CA 2153419A1 CA 002153419 A CA002153419 A CA 002153419A CA 2153419 A CA2153419 A CA 2153419A CA 2153419 A1 CA2153419 A1 CA 2153419A1
- Authority
- CA
- Canada
- Prior art keywords
- radical
- preparation
- pharmaceutical compositions
- compositions containing
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 alkyl radical Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical group O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nouveaux taxoïdes de formule générale (I), leur préparation et les compositions pharmaceutiques qui les contiennent. Dans la formule générale (I), Ar représente un radical aryle, R représente un atome d'hydrogène ou un radical acétyle ou alcoxyacétyle, R1 représente un radical benzoyle ou un radical R2-O-CO- dans lequel R2 représente un radical alcoyle, alcényle, cycloalcoyle, cycloalcényle, bicycloalcyle, phényle ou hétérocyclyle et R3 représente un radical alcoyle, alcényle, cycloalcoyle, cycloalcényle, bicycloalcoyle, aryle éventuellement substitué (à l'exception de phényle non substitué) ou hétéroyclyle. Les produits de formule générale (I) présentent des propriétés antitumorales remarquables.New taxoids of general formula (I), their preparation and the pharmaceutical compositions containing them. In the general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl or alkoxyacetyl radical, R1 represents a benzoyl radical or an R2-O-CO- radical in which R2 represents an alkyl radical, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl and R3 represents an alkyl, alkenyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted aryl (except for unsubstituted phenyl) or heteroyclyl radical. The products of general formula (I) have remarkable anti-tumor properties.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9302370A FR2702212B1 (en) | 1993-03-02 | 1993-03-02 | New taxoids, their preparation and the pharmaceutical compositions containing them. |
| FR93/02370 | 1993-03-02 | ||
| PCT/FR1994/000222 WO1994020484A1 (en) | 1993-03-02 | 1994-02-28 | Novel taxoids, preparation thereof and pharmaceutical compositions containing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2153419A1 true CA2153419A1 (en) | 1994-09-15 |
| CA2153419C CA2153419C (en) | 2007-01-02 |
Family
ID=37603318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002153419A Expired - Lifetime CA2153419C (en) | 1993-03-02 | 1994-02-28 | Novel taxoids, preparation thereof and pharmaceutical compositions containing same |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2153419C (en) |
-
1994
- 1994-02-28 CA CA002153419A patent/CA2153419C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2153419C (en) | 2007-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140228 |