CA2214320A1 - Novel taxoids, preparation thereof, and pharmaceutical compositions containing same - Google Patents
Novel taxoids, preparation thereof, and pharmaceutical compositions containing sameInfo
- Publication number
- CA2214320A1 CA2214320A1 CA002214320A CA2214320A CA2214320A1 CA 2214320 A1 CA2214320 A1 CA 2214320A1 CA 002214320 A CA002214320 A CA 002214320A CA 2214320 A CA2214320 A CA 2214320A CA 2214320 A1 CA2214320 A1 CA 2214320A1
- Authority
- CA
- Canada
- Prior art keywords
- radical
- general formula
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 alkyl radical Chemical class 0.000 abstract 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical class O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nouveaux taxoïdes de formule générale (I), leur préparation et les compositions pharmaceutiques qui les contiennent. Dans la formule générale (I), Z représente un atome d'hydrogène ou un radical de formule générale (II) dans laquelle R1 représente un radical benzoyle éventuellement substitué ou un radical R2-O-CO- dans lequel R2 représente un radical alcoyle, alcényle, alcynyle, cycloalcoyle, cycloalcényle, bicycloalcoyle, phényle éventuellement substitué ou hétérocyclyle, R3 représente un radical alcoyle, alcényle, alcynyle, cycloalcoyle, phényle, naphtyle ou hétérocyclique aromatique, R4 représente un radical alcoxy, alcényloxy, alcynyloxy, cycloalcoyloxy ou cycloalcényloxy éventuellement substitué. Les nouveaux produits de formule générale (I) dans laquelle Z représente un radical de formule générale (II) présentent des propriétés antitumorales et antileucémiques remarquables.New taxoids of general formula (I), their preparation and the pharmaceutical compositions containing them. In the general formula (I), Z represents a hydrogen atom or a radical of general formula (II) in which R1 represents an optionally substituted benzoyl radical or a radical R2-O-CO- in which R2 represents an alkyl radical, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl, R3 represents an alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl or heterocyclic aromatic radical, R4 represents an alkoxyalkyl, cycloalkylalkyl or alkoxyalkyloxy, . The new products of general formula (I) in which Z represents a radical of general formula (II) have remarkable antitumor and antileukemic properties.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9504559 | 1995-04-14 | ||
FR9504559A FR2732968B1 (en) | 1995-04-14 | 1995-04-14 | NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
PCT/FR1996/000559 WO1996032387A1 (en) | 1995-04-14 | 1996-04-12 | Novel taxoids, preparation thereof, and pharmaceutical compositions containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2214320A1 true CA2214320A1 (en) | 1996-10-17 |
CA2214320C CA2214320C (en) | 2007-02-06 |
Family
ID=37734888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002214320A Expired - Fee Related CA2214320C (en) | 1995-04-14 | 1996-04-12 | Novel taxoids, preparation thereof, and pharmaceutical compositions containing same |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2214320C (en) |
-
1996
- 1996-04-12 CA CA002214320A patent/CA2214320C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2214320C (en) | 2007-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150413 |