CA2139754A1 - Low light color imaging system with cooled integrating camera - Google Patents
Low light color imaging system with cooled integrating cameraInfo
- Publication number
- CA2139754A1 CA2139754A1 CA002139754A CA2139754A CA2139754A1 CA 2139754 A1 CA2139754 A1 CA 2139754A1 CA 002139754 A CA002139754 A CA 002139754A CA 2139754 A CA2139754 A CA 2139754A CA 2139754 A1 CA2139754 A1 CA 2139754A1
- Authority
- CA
- Canada
- Prior art keywords
- image
- color
- biological sample
- imaging
- colors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003384 imaging method Methods 0.000 title claims abstract description 46
- 239000003086 colorant Substances 0.000 claims abstract description 39
- 238000001816 cooling Methods 0.000 claims abstract description 30
- 239000007850 fluorescent dye Substances 0.000 claims abstract description 9
- 239000012472 biological sample Substances 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 13
- 230000005693 optoelectronics Effects 0.000 claims description 13
- 239000000523 sample Substances 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 238000009826 distribution Methods 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims 5
- 238000009833 condensation Methods 0.000 claims 5
- 239000007789 gas Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 238000009595 pap smear Methods 0.000 abstract 1
- 230000003442 weekly effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 17
- 239000000975 dye Substances 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 230000005945 translocation Effects 0.000 description 6
- 101150049556 Bcr gene Proteins 0.000 description 4
- 241000282320 Panthera leo Species 0.000 description 4
- 238000010191 image analysis Methods 0.000 description 4
- 210000004940 nucleus Anatomy 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 239000003298 DNA probe Substances 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 108020003215 DNA Probes Proteins 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
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- 210000000805 cytoplasm Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- YFONKFDEZLYQDH-OPQQBVKSSA-N N-[(1R,2S)-2,6-dimethyindan-1-yl]-6-[(1R)-1-fluoroethyl]-1,3,5-triazine-2,4-diamine Chemical compound C[C@@H](F)C1=NC(N)=NC(N[C@H]2C3=CC(C)=CC=C3C[C@@H]2C)=N1 YFONKFDEZLYQDH-OPQQBVKSSA-N 0.000 description 1
- 241000950638 Symphysodon discus Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 108700025690 abl Genes Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000004214 philadelphia chromosome Anatomy 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/50—Constructional details
- H04N23/51—Housings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
- G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Multimedia (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Color Television Image Signal Generators (AREA)
- Connector Housings Or Holding Contact Members (AREA)
- Spectrometry And Color Measurement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91070892A | 1992-07-08 | 1992-07-08 | |
| US910,708 | 1992-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2139754A1 true CA2139754A1 (en) | 1994-01-20 |
Family
ID=25429219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002139754A Abandoned CA2139754A1 (en) | 1992-07-08 | 1993-07-08 | Low light color imaging system with cooled integrating camera |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0691064A1 (de) |
| JP (1) | JPH07509819A (de) |
| AU (1) | AU4669593A (de) |
| CA (1) | CA2139754A1 (de) |
| WO (1) | WO1994001968A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834203A (en) * | 1997-08-25 | 1998-11-10 | Applied Spectral Imaging | Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore |
| EP1576806A1 (de) * | 2002-12-04 | 2005-09-21 | Applied Precision, LLC | Thermisch effizientes gehäuse einer ccd-kamera |
| US8644580B2 (en) * | 2008-08-07 | 2014-02-04 | Cambridge Research & Instrumentation, Inc. | Detection of RNA in tissue samples |
| US8416302B2 (en) | 2009-02-10 | 2013-04-09 | Microsoft Corporation | Low-light imaging augmented with non-intrusive lighting |
| CA2860997C (en) * | 2012-01-19 | 2017-10-10 | Shanghai Ruishi Machine Vision Technology Co., Ltd. | Camera with built-in polarizer switching mechanism |
| FR3037399B1 (fr) * | 2015-06-12 | 2019-06-14 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Dispositif d'imagerie sans lentille |
| CN115308176B (zh) * | 2022-07-26 | 2024-09-13 | 山东大学 | 一种癌变细胞判别用口腔黏膜多频荧光成像系统及方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58148572A (ja) * | 1982-02-27 | 1983-09-03 | Sony Corp | 固体撮像装置 |
| DE3304782A1 (de) * | 1983-02-11 | 1984-08-16 | Egyt Gyógyszervegyészeti Gyár, Budapest | Verfahren und messgeraet zur zerstoerungsfreien schnellidentifizierung von anorganischen und organischen stoffen |
| GB2146865A (en) * | 1983-09-16 | 1985-04-24 | Rca Corp | Camera with reduced condensation cooled solid-state imager |
| US4551760A (en) * | 1983-09-16 | 1985-11-05 | Rca Corporation | Television camera with solid-state imagers cooled by a thermal servo |
| US4547809A (en) * | 1984-04-27 | 1985-10-15 | Rca Corporation | Thermally isolated imager |
| US4587563A (en) * | 1984-09-28 | 1986-05-06 | Rca Corporation | Cooler control for a solid-state imager camera |
| US5008185A (en) * | 1985-11-04 | 1991-04-16 | Cell Analysis Systems, Inc. | Methods and apparatus for the quantitation of nuclear proteins |
| US4998284A (en) * | 1987-11-17 | 1991-03-05 | Cell Analysis Systems, Inc. | Dual color camera microscope and methodology for cell staining and analysis |
| US4739409A (en) * | 1986-10-10 | 1988-04-19 | Eastman Kodak Company | Intelligent exposure control for electronic cameras |
| GB2196219A (en) * | 1986-10-11 | 1988-04-20 | Astromed Ltd | Imaging of light-opaque specimens by transmission of radiation therethrough |
| DE3812899A1 (de) * | 1988-04-18 | 1989-10-26 | Wilfried Heil | Elektronische kamera zur dokumentation von fluoreszenzmustern auf elektrophoresegelen |
| JPH0271683A (ja) * | 1988-09-06 | 1990-03-12 | Fuji Photo Film Co Ltd | Ｃｃｄパッケージ |
| US5087965A (en) * | 1989-06-28 | 1992-02-11 | American Innovision, Inc. | Recognition of image colors using arbitrary shapes in color space |
| US5221964A (en) * | 1991-08-05 | 1993-06-22 | Dalsa Inc | Electronically expandable modular ccd camera |
| US5216250A (en) * | 1991-11-27 | 1993-06-01 | Lorad Corporation | Digital imaging system using CCD array |
| JPH06331278A (ja) * | 1993-05-26 | 1994-11-29 | Nippon Steel Corp | 直流アーク炉の絶縁監視方法 |
-
1993
- 1993-07-08 AU AU46695/93A patent/AU4669593A/en not_active Withdrawn
- 1993-07-08 EP EP93917039A patent/EP0691064A1/de not_active Withdrawn
- 1993-07-08 JP JP6503513A patent/JPH07509819A/ja active Pending
- 1993-07-08 CA CA002139754A patent/CA2139754A1/en not_active Abandoned
- 1993-07-08 WO PCT/US1993/006442 patent/WO1994001968A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0691064A1 (de) | 1996-01-10 |
| EP0691064A4 (de) | 1995-11-03 |
| AU4669593A (en) | 1994-01-31 |
| WO1994001968A1 (en) | 1994-01-20 |
| JPH07509819A (ja) | 1995-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 19990708 |