CA2137342A1 - Test quantitatif pour la determination du temps de thrombine - Google Patents

Test quantitatif pour la determination du temps de thrombine

Info

Publication number
CA2137342A1
CA2137342A1 CA 2137342 CA2137342A CA2137342A1 CA 2137342 A1 CA2137342 A1 CA 2137342A1 CA 2137342 CA2137342 CA 2137342 CA 2137342 A CA2137342 A CA 2137342A CA 2137342 A1 CA2137342 A1 CA 2137342A1
Authority
CA
Canada
Prior art keywords
thrombin
fibrinogen
plasma
concentration
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2137342
Other languages
English (en)
Inventor
Thomas Reid
Barbara Alving
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Army
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/021,033 external-priority patent/US5476771A/en
Application filed by Individual filed Critical Individual
Publication of CA2137342A1 publication Critical patent/CA2137342A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA 2137342 1992-06-05 1993-06-03 Test quantitatif pour la determination du temps de thrombine Abandoned CA2137342A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89363192A 1992-06-05 1992-06-05
US07/893,631 1992-06-05
US08/021,033 US5476771A (en) 1993-02-22 1993-02-22 Test for quantitative thrombin time
US08/021,033 1993-02-22

Publications (1)

Publication Number Publication Date
CA2137342A1 true CA2137342A1 (fr) 1993-12-23

Family

ID=26694177

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2137342 Abandoned CA2137342A1 (fr) 1992-06-05 1993-06-03 Test quantitatif pour la determination du temps de thrombine

Country Status (5)

Country Link
EP (1) EP0643727A4 (fr)
JP (1) JPH08501682A (fr)
AU (2) AU4405293A (fr)
CA (1) CA2137342A1 (fr)
WO (2) WO1993025220A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041432A1 (fr) * 1996-04-30 1997-11-06 Medtronic, Inc. Procede pour determiner la reponse d'un inhibiteur de plaquettes
US6221672B1 (en) 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
JP3626982B2 (ja) * 1997-08-29 2005-03-09 アークレイ株式会社 タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット
EP2622354A1 (fr) * 2010-10-01 2013-08-07 Rigshospitalet Composés capables de moduler/préserver l'intégrité endothéliale à utiliser dans la prévention ou le traitement de la coagulopathie traumatique aiguë et la réanimation après arrêt cardiaque
WO2013143548A1 (fr) * 2012-03-30 2013-10-03 Rigshospitalet Composés capables de moduler/préserver l'intégrité endothéliale et adaptés pour être utilisés dans la prévention ou le traitement de la coagulopathie traumatique aiguë et la réanimation après arrêt cardiaque
CN117741166B (zh) * 2024-02-19 2024-04-26 北京水木济衡生物技术有限公司 一种多项目复合凝血质控品及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3038163A1 (de) * 1980-10-09 1982-05-06 Boehringer Mannheim Gmbh, 6800 Mannheim Thrombininhibitor, seine herstellung und verwendung
WO1982001377A1 (fr) * 1980-10-09 1982-04-29 Lill Helmut Procede de determination d'une bm ('binding moderately') antithrombine
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US5019393A (en) * 1988-08-03 1991-05-28 New England Deaconess Hospital Corporation Biocompatible substance with thromboresistance
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
EP0442843B1 (fr) * 1990-02-14 1998-09-09 Pentapharm A.G. Inhibiteur pour le prétraitement anticoagulant des échantillons sanguins
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin

Also Published As

Publication number Publication date
WO1993025220A1 (fr) 1993-12-23
JPH08501682A (ja) 1996-02-27
AU4768193A (en) 1994-01-04
EP0643727A1 (fr) 1995-03-22
EP0643727A4 (fr) 1998-05-13
WO1993025578A1 (fr) 1993-12-23
AU4405293A (en) 1994-01-04

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Legal Events

Date Code Title Description
FZDE Dead