CA2136610C - Method for production of a whey protein hydrolyzate and a whey protein hydrolyzate - Google Patents
Method for production of a whey protein hydrolyzate and a whey protein hydrolyzate Download PDFInfo
- Publication number
- CA2136610C CA2136610C CA002136610A CA2136610A CA2136610C CA 2136610 C CA2136610 C CA 2136610C CA 002136610 A CA002136610 A CA 002136610A CA 2136610 A CA2136610 A CA 2136610A CA 2136610 C CA2136610 C CA 2136610C
- Authority
- CA
- Canada
- Prior art keywords
- fact
- protein hydrolyzate
- whey protein
- content
- hydrolysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108010046377 Whey Proteins Proteins 0.000 title claims abstract description 42
- 102000007544 Whey Proteins Human genes 0.000 title claims abstract description 40
- 235000021119 whey protein Nutrition 0.000 title claims abstract description 40
- 239000003531 protein hydrolysate Substances 0.000 title claims abstract description 39
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 44
- 230000007062 hydrolysis Effects 0.000 claims abstract description 13
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 13
- 239000007858 starting material Substances 0.000 claims abstract description 8
- 230000002378 acidificating effect Effects 0.000 claims abstract description 6
- 239000005018 casein Substances 0.000 claims abstract description 6
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000021240 caseins Nutrition 0.000 claims abstract description 6
- 238000001556 precipitation Methods 0.000 claims abstract description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 238000009826 distribution Methods 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 230000002779 inactivation Effects 0.000 claims description 7
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 239000004365 Protease Substances 0.000 claims description 6
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 6
- 230000009467 reduction Effects 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 238000000108 ultra-filtration Methods 0.000 claims description 5
- 102000005158 Subtilisins Human genes 0.000 claims description 4
- 108010056079 Subtilisins Proteins 0.000 claims description 4
- 108010009355 microbial metalloproteinases Proteins 0.000 claims description 4
- 238000001728 nano-filtration Methods 0.000 claims description 4
- 238000010979 pH adjustment Methods 0.000 claims description 4
- 239000002002 slurry Substances 0.000 claims description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- 235000011116 calcium hydroxide Nutrition 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 239000012466 permeate Substances 0.000 claims description 3
- 238000001223 reverse osmosis Methods 0.000 claims description 3
- 102000035195 Peptidases Human genes 0.000 claims description 2
- 102000004142 Trypsin Human genes 0.000 claims description 2
- 108090000631 Trypsin Proteins 0.000 claims description 2
- 239000005862 Whey Substances 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 238000001471 micro-filtration Methods 0.000 claims description 2
- 239000012465 retentate Substances 0.000 claims description 2
- 239000012588 trypsin Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 description 17
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 7
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 235000020183 skimmed milk Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 5
- 230000009257 reactivity Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 4
- GNNALEGJVYVIIH-UHFFFAOYSA-N benzene-1,2-diamine;hydrochloride Chemical compound Cl.NC1=CC=CC=C1N GNNALEGJVYVIIH-UHFFFAOYSA-N 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000003643 water by type Substances 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 239000013566 allergen Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 235000020247 cow milk Nutrition 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 3
- APOYTRAZFJURPB-UHFFFAOYSA-N 2-methoxy-n-(2-methoxyethyl)-n-(trifluoro-$l^{4}-sulfanyl)ethanamine Chemical compound COCCN(S(F)(F)F)CCOC APOYTRAZFJURPB-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- FBEHFRAORPEGFH-UHFFFAOYSA-N Allyxycarb Chemical compound CNC(=O)OC1=CC(C)=C(N(CC=C)CC=C)C(C)=C1 FBEHFRAORPEGFH-UHFFFAOYSA-N 0.000 description 1
- 241000194108 Bacillus licheniformis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 101150013573 INVE gene Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010028164 Multiple allergies Diseases 0.000 description 1
- 101100286588 Mus musculus Igfl gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 101150076562 virB gene Proteins 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK712/92 | 1992-05-27 | ||
| DK92712A DK71292D0 (https=) | 1992-05-27 | 1992-05-27 | |
| PCT/DK1993/000182 WO1993024020A1 (en) | 1992-05-27 | 1993-05-26 | Method for production of a whey protein hydrolyzate and a whey protein hydrolyzate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2136610A1 CA2136610A1 (en) | 1993-12-09 |
| CA2136610C true CA2136610C (en) | 2004-10-05 |
Family
ID=8096674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002136610A Expired - Fee Related CA2136610C (en) | 1992-05-27 | 1993-05-26 | Method for production of a whey protein hydrolyzate and a whey protein hydrolyzate |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0642307B1 (https=) |
| JP (1) | JP3230681B2 (https=) |
| AT (1) | ATE161689T1 (https=) |
| AU (1) | AU668400B2 (https=) |
| CA (1) | CA2136610C (https=) |
| DE (1) | DE69316207T2 (https=) |
| DK (2) | DK71292D0 (https=) |
| ES (1) | ES2114055T3 (https=) |
| GR (1) | GR3026293T3 (https=) |
| NZ (1) | NZ253019A (https=) |
| WO (1) | WO1993024020A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405637A (en) * | 1993-06-30 | 1995-04-11 | Bristol-Myers Squibb Company | Milk protein partial hydrolysate and infant formula containing same |
| US5618689A (en) * | 1995-05-25 | 1997-04-08 | Nestec S.A. | Enhanced procedures for preparing food hydrolysates |
| DK1087668T3 (da) | 1998-06-17 | 2005-01-24 | New Zealand Dairy Board | Bioaktivt valleproteinhydrolysat |
| NZ506866A (en) * | 2000-09-11 | 2003-05-30 | New Zealand Dairy Board | Bioactive whey protein hydrolysate free of bitter flavours wherein the enzyme used is a heat labile protease |
| WO2003059083A1 (de) * | 2002-01-21 | 2003-07-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Molkenproteinhydrolysate und peptidfraktionen aus molkenprotein mit bioaktiver wirkung aus hydrolysen mit proteasen |
| PL368179A1 (en) * | 2004-05-24 | 2005-11-28 | Sgp & Sons Ab | Proteollytic method for processing proteins and protein hydrolysis products, enriched with exogenous, semi-exogenous and conditionally exogenous amino acids for making therapeutic preparation used in normal and medicinal diets |
| DE102008032828A1 (de) * | 2008-07-02 | 2010-01-07 | Technische Universität Dresden | Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel |
| US9055752B2 (en) | 2008-11-06 | 2015-06-16 | Intercontinental Great Brands Llc | Shelf-stable concentrated dairy liquids and methods of forming thereof |
| CN102378581A (zh) * | 2009-04-02 | 2012-03-14 | 诺维信公司 | 用于制备基于乳的蛋白质水解产物的方法 |
| UA112972C2 (uk) | 2010-09-08 | 2016-11-25 | Інтерконтінентал Грейт Брендс ЛЛС | Рідкий молочний концентрат з високим вмістом сухих речовин |
| KR101698379B1 (ko) * | 2015-09-17 | 2017-01-20 | 삼육대학교산학협력단 | 산양유 단백질 가수분해물, 그것의 제조방법 및 그것의 식품에 사용하는 용도 |
| RU2663583C2 (ru) * | 2015-12-30 | 2018-08-07 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр пищевых систем им. В.М. Горбатова" РАН | Способ производства гидролизата сывороточных белков |
| CN109310128A (zh) | 2016-04-08 | 2019-02-05 | 弗劳恩霍夫应用研究促进协会 | 来自于豆科或油料果实的工艺技术功能植物蛋白分馏物 |
| BR112020012263A2 (pt) | 2018-01-16 | 2020-11-24 | Frieslandcampina Nederland B.V. | método de fornecimento de uma composição nutricional hipoalergênica para bebês que correm o risco de desenvolver alergia ao leite de vaca, composição nutricional hipoalergênica para bebês, método para limpar um hidrolisado parcial de proteína(s) do leite de um ou mais componentes capazes de se ligarem ao rage e/ou que possuem a capacidade de induzir a desgranulação de basófilos, e, hidrolisado parcial de proteína(s) do leite. |
| FI3975733T3 (fi) * | 2019-05-29 | 2023-11-02 | Arla Foods Amba | Maittavia, pitkälle hydrolysoituja heraproteiinihydrolysaatteja |
| CA3211852A1 (en) | 2021-03-02 | 2022-09-09 | Arla Foods Amba | Immunogenic protein hydrolysate with reduced allergenicity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2459620B1 (fr) * | 1979-06-26 | 1983-08-05 | Agronomique Inst Nat Rech | Hydrolisat enzymatique total de proteines de lactoserum, obtention et application |
| EP0065663A1 (en) * | 1981-05-11 | 1982-12-01 | Miles Laboratories, Inc. | Method for the preparation of a protein hydrolyzate from whey protein |
| FR2608051B1 (fr) * | 1986-12-15 | 1989-04-07 | Bellon Labor Sa Roger | Procede de fabrication d'un hydrolysat enzymatique de proteines riche en di- et tri-peptides, utilisable notamment en nutrition artificielle et en dietetique |
| BE1003298A3 (nl) * | 1990-01-12 | 1992-02-18 | Tessenderlo Chem Nv | Werkwijze voor het bereiden van een enzymatisch hydrolysaat. |
| JP3153237B2 (ja) * | 1990-03-09 | 2001-04-03 | ノボ ノルディスク アクティーゼルスカブ | タンパク質加水分解物 |
| DK3991D0 (da) * | 1991-01-10 | 1991-01-10 | Novo Nordisk As | Fremgangsmaade til fremstilling af et proteinhydrolysat |
| ES2097328T3 (es) * | 1991-05-31 | 1997-04-01 | Danmark Protein As | Metodo para la produccion de proteina de suero lacteo. |
| EP0604467A1 (en) * | 1991-08-30 | 1994-07-06 | Teagasc, The Agriculture And Food Development Authority | Hypoallergenic whey protein hydrolysate |
-
1992
- 1992-05-27 DK DK92712A patent/DK71292D0/da unknown
-
1993
- 1993-05-26 JP JP50009794A patent/JP3230681B2/ja not_active Expired - Fee Related
- 1993-05-26 NZ NZ253019A patent/NZ253019A/xx not_active IP Right Cessation
- 1993-05-26 ES ES93912667T patent/ES2114055T3/es not_active Expired - Lifetime
- 1993-05-26 EP EP93912667A patent/EP0642307B1/en not_active Expired - Lifetime
- 1993-05-26 AT AT93912667T patent/ATE161689T1/de not_active IP Right Cessation
- 1993-05-26 AU AU43099/93A patent/AU668400B2/en not_active Ceased
- 1993-05-26 DE DE69316207T patent/DE69316207T2/de not_active Expired - Fee Related
- 1993-05-26 DK DK93912667T patent/DK0642307T3/da active
- 1993-05-26 CA CA002136610A patent/CA2136610C/en not_active Expired - Fee Related
- 1993-05-26 WO PCT/DK1993/000182 patent/WO1993024020A1/en not_active Ceased
-
1998
- 1998-03-06 GR GR980400464T patent/GR3026293T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69316207T2 (de) | 1998-06-25 |
| EP0642307A1 (en) | 1995-03-15 |
| ES2114055T3 (es) | 1998-05-16 |
| JPH07506971A (ja) | 1995-08-03 |
| AU668400B2 (en) | 1996-05-02 |
| NZ253019A (en) | 1995-12-21 |
| DK0642307T3 (da) | 1998-09-07 |
| AU4309993A (en) | 1993-12-30 |
| EP0642307B1 (en) | 1998-01-07 |
| ATE161689T1 (de) | 1998-01-15 |
| CA2136610A1 (en) | 1993-12-09 |
| DK71292D0 (https=) | 1992-05-27 |
| GR3026293T3 (en) | 1998-06-30 |
| WO1993024020A1 (en) | 1993-12-09 |
| JP3230681B2 (ja) | 2001-11-19 |
| DE69316207D1 (de) | 1998-02-12 |
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