CA2128591A1 - Controlled Release Formulations Coated with Aqueous Dispersions of Acrylic Polymers - Google Patents

Controlled Release Formulations Coated with Aqueous Dispersions of Acrylic Polymers

Info

Publication number
CA2128591A1
CA2128591A1 CA 2128591 CA2128591A CA2128591A1 CA 2128591 A1 CA2128591 A1 CA 2128591A1 CA 2128591 CA2128591 CA 2128591 CA 2128591 A CA2128591 A CA 2128591A CA 2128591 A1 CA2128591 A1 CA 2128591A1
Authority
CA
Canada
Prior art keywords
agent
controlled release
release formulations
acrylic polymers
aqueous dispersions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2128591
Other languages
French (fr)
Other versions
CA2128591C (en
Inventor
Benjamin Oshlack
Mark Chasin
Frank Pedi, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroceltique SA
Original Assignee
Benjamin Oshlack
Mark Chasin
Frank Pedi, Jr.
Euroceltique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US08/097,558 priority Critical patent/US5580578A/en
Priority to US097,558 priority
Application filed by Benjamin Oshlack, Mark Chasin, Frank Pedi, Jr., Euroceltique, S.A. filed Critical Benjamin Oshlack
Publication of CA2128591A1 publication Critical patent/CA2128591A1/en
Application granted granted Critical
Publication of CA2128591C publication Critical patent/CA2128591C/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally active therapeutic agent, a disinfecting and sanitizing agent, a cleansing agent, a fragrance agent and a fertilizing agent, overcoated with an aqueous dispersion of the plasticized water-insoluble acrylic polymer.
The formulation provides a stable dissolution of the active agent which is unchanged after exposure to accelerated storage conditions.
CA 2128591 1992-01-27 1994-07-21 Controlled release formulations coated with aqueous dispersions of acrylic polymers Expired - Lifetime CA2128591C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US08/097,558 US5580578A (en) 1992-01-27 1993-07-27 Controlled release formulations coated with aqueous dispersions of acrylic polymers
US097,558 1993-07-27

Publications (2)

Publication Number Publication Date
CA2128591A1 true CA2128591A1 (en) 1995-01-28
CA2128591C CA2128591C (en) 1999-03-23

Family

ID=22264016

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2128591 Expired - Lifetime CA2128591C (en) 1992-01-27 1994-07-21 Controlled release formulations coated with aqueous dispersions of acrylic polymers

Country Status (4)

Country Link
US (3) US5580578A (en)
EP (1) EP0636366A3 (en)
AU (1) AU686168B2 (en)
CA (1) CA2128591C (en)

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AU6868994A (en) 1995-02-09
US5580578A (en) 1996-12-03

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