CA2122992A1 - Leukotriene-b derivatives, process for preparing the same and medicaments - Google Patents

Leukotriene-b derivatives, process for preparing the same and medicaments

Info

Publication number
CA2122992A1
CA2122992A1 CA002122992A CA2122992A CA2122992A1 CA 2122992 A1 CA2122992 A1 CA 2122992A1 CA 002122992 A CA002122992 A CA 002122992A CA 2122992 A CA2122992 A CA 2122992A CA 2122992 A1 CA2122992 A1 CA 2122992A1
Authority
CA
Canada
Prior art keywords
hydroxy
acetoxy
tridecadienyl
acid
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002122992A
Other languages
English (en)
French (fr)
Inventor
Werner Skuballa
Bernd Buchmann
Josef Heindl
Wolfgang Frohlich
Roland Ekerdt
Claudia Giesen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4139869A external-priority patent/DE4139869A1/de
Priority claimed from DE4139868A external-priority patent/DE4139868A1/de
Application filed by Schering AG filed Critical Schering AG
Publication of CA2122992A1 publication Critical patent/CA2122992A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0058—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a not condensed ring different from a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Furan Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002122992A 1991-11-29 1992-11-19 Leukotriene-b derivatives, process for preparing the same and medicaments Abandoned CA2122992A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4139869A DE4139869A1 (de) 1991-11-29 1991-11-29 Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DEP4139868.8 1991-11-29
DEP4139869.6 1991-11-29
DE4139868A DE4139868A1 (de) 1991-11-29 1991-11-29 Neue Leukotrien-B¶4¶-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
CA2122992A1 true CA2122992A1 (en) 1993-06-10

Family

ID=25909745

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002122992A Abandoned CA2122992A1 (en) 1991-11-29 1992-11-19 Leukotriene-b derivatives, process for preparing the same and medicaments

Country Status (14)

Country Link
US (1) US5502075A (enExample)
EP (1) EP0614457B1 (enExample)
JP (1) JPH07505129A (enExample)
AT (1) ATE141593T1 (enExample)
AU (1) AU676670B2 (enExample)
CA (1) CA2122992A1 (enExample)
DE (1) DE59206968D1 (enExample)
DK (1) DK0614457T3 (enExample)
ES (1) ES2093280T3 (enExample)
GR (1) GR3021761T3 (enExample)
HU (1) HUT70477A (enExample)
NO (1) NO941978L (enExample)
PT (1) PT101093A (enExample)
WO (1) WO1993011105A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701477B1 (fr) * 1993-02-16 1995-03-31 Adir Nouveaux composés (cyclohexyl)alcéniques, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
US8729108B2 (en) * 2008-06-17 2014-05-20 Christopher J Dannaker Waterborne topical compositions for the delivery of active ingredients such as azelaic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5069848A (en) * 1989-04-05 1991-12-03 Mitsui Toatsu Chemicals, Inc. Extrusion process of polyimide and polyimide pellet used for the process
DE3917597A1 (de) * 1989-05-26 1990-11-29 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE4108351A1 (de) * 1991-03-12 1992-09-17 Schering Ag Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
JPH07505129A (ja) 1995-06-08
DE59206968D1 (de) 1996-09-26
US5502075A (en) 1996-03-26
HU9401458D0 (en) 1994-08-29
AU2943592A (en) 1993-06-28
DK0614457T3 (enExample) 1997-02-24
NO941978L (no) 1994-07-29
EP0614457A1 (de) 1994-09-14
EP0614457B1 (de) 1996-08-21
AU676670B2 (en) 1997-03-20
ES2093280T3 (es) 1996-12-16
PT101093A (pt) 1994-02-28
GR3021761T3 (en) 1997-02-28
ATE141593T1 (de) 1996-09-15
HUT70477A (en) 1995-10-30
WO1993011105A1 (de) 1993-06-10
NO941978D0 (no) 1994-05-27

Similar Documents

Publication Publication Date Title
US5187286A (en) Leukotriene-b4 derivatives, process for their production and their use as pharmaceutical agents
US5414016A (en) New leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
CA2082818A1 (en) Leukotriene b4 derivatives, method for preparing them and their use as drugs
CA2122992A1 (en) Leukotriene-b derivatives, process for preparing the same and medicaments
EP0234576B1 (en) Prostacyclin analogue, and blood circulation improving agent and anti-ulcer composition containing it as active ingredient
US5783602A (en) Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents
US5196570A (en) Leukotriene-b4 derivatives, process for their production and their use as pharmaceutical agents
DE4242390A1 (de) Neue Leukotiren-B¶4¶-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5859054A (en) Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents
CA2182191A1 (en) New leukotriene b4 derivatives, methods of preparing them and their use as drugs
US6340706B1 (en) Leukotriene-B4 derivatives, in particular 7-methylcyclohexyl-LTB4 antagonists
US5183925A (en) Leukotriene-b4 derivatives, process for their production and their use as pharmaceutical agents
US6160012A (en) Leukotriene B4 derivatives, in particular oximo-LTB4 - antagonists
IE66678B1 (en) New leukotriene B4 derivatives a process for their production and their use as pharmaceutical agents
HUT75342A (en) New leukotriene b4 derivatives, methods of preparing them and their use as drugs
DE4236540A1 (de) Neue Leukotrien-B¶4¶-Derivate, Verfahren zu ihrer H erstellung und ihre Verwendung als Arzneimittel
DE4139868A1 (de) Neue Leukotrien-B¶4¶-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4139869A1 (de) Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Legal Events

Date Code Title Description
FZDE Discontinued