CA2118212A1 - Azote de substitution renfermant des composes spiranniques pour usage dans le traitement des deficits cognitifs - Google Patents

Azote de substitution renfermant des composes spiranniques pour usage dans le traitement des deficits cognitifs

Info

Publication number
CA2118212A1
CA2118212A1 CA002118212A CA2118212A CA2118212A1 CA 2118212 A1 CA2118212 A1 CA 2118212A1 CA 002118212 A CA002118212 A CA 002118212A CA 2118212 A CA2118212 A CA 2118212A CA 2118212 A1 CA2118212 A1 CA 2118212A1
Authority
CA
Canada
Prior art keywords
compound
mammal
effective amount
therapeutically effective
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002118212A
Other languages
English (en)
Inventor
Matthew M. Abelman
David R. Brittelli
David A. Nugiel
Matthew E. Voss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2118212A1 publication Critical patent/CA2118212A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002118212A 1992-04-16 1993-04-15 Azote de substitution renfermant des composes spiranniques pour usage dans le traitement des deficits cognitifs Abandoned CA2118212A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86916392A 1992-04-16 1992-04-16
US07/869,163 1992-04-16

Publications (1)

Publication Number Publication Date
CA2118212A1 true CA2118212A1 (fr) 1993-10-28

Family

ID=25353043

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002118212A Abandoned CA2118212A1 (fr) 1992-04-16 1993-04-15 Azote de substitution renfermant des composes spiranniques pour usage dans le traitement des deficits cognitifs

Country Status (5)

Country Link
EP (1) EP0636132A1 (fr)
JP (1) JPH07507772A (fr)
AU (1) AU4027693A (fr)
CA (1) CA2118212A1 (fr)
WO (1) WO1993021185A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1928454T3 (da) 2005-05-10 2014-11-03 Intermune Inc Pyridonderivater til modulering af stress-aktiveret proteinkinasesystem
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
US10343991B2 (en) 2016-11-02 2019-07-09 Council Of Scientific & Industrial Research C5, C6 substituted and/or fused oxindoles as anti-cancer agents and process for preparation thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US5173489A (en) * 1986-04-10 1992-12-22 The Dupont Merck Pharmaceutical Co. α,α-disubstituted aromatics and heteroaromatics as cognition enhancers

Also Published As

Publication number Publication date
JPH07507772A (ja) 1995-08-31
EP0636132A1 (fr) 1995-02-01
AU4027693A (en) 1993-11-18
WO1993021185A1 (fr) 1993-10-28

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Legal Events

Date Code Title Description
FZDE Dead