CA2115332A1 - Propanolamine derivatives - Google Patents

Propanolamine derivatives

Info

Publication number
CA2115332A1
CA2115332A1 CA002115332A CA2115332A CA2115332A1 CA 2115332 A1 CA2115332 A1 CA 2115332A1 CA 002115332 A CA002115332 A CA 002115332A CA 2115332 A CA2115332 A CA 2115332A CA 2115332 A1 CA2115332 A1 CA 2115332A1
Authority
CA
Canada
Prior art keywords
tert
compound
butyl
piperazinyl
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002115332A
Other languages
English (en)
French (fr)
Inventor
Kazumi Ogata
Takahiro Sakaue
Yuuichi Isowaki
Takaaki Deguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Publication of CA2115332A1 publication Critical patent/CA2115332A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002115332A 1993-02-15 1994-02-09 Propanolamine derivatives Abandoned CA2115332A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25361-1993 1993-02-15
JP2536193 1993-02-15
JP25673993 1993-10-14
JP256739-1993 1993-10-14

Publications (1)

Publication Number Publication Date
CA2115332A1 true CA2115332A1 (en) 1994-08-16

Family

ID=26362958

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002115332A Abandoned CA2115332A1 (en) 1993-02-15 1994-02-09 Propanolamine derivatives

Country Status (5)

Country Link
US (1) US5504087A (en, 2012)
EP (1) EP0611748A1 (en, 2012)
KR (1) KR940019671A (en, 2012)
CA (1) CA2115332A1 (en, 2012)
TW (1) TW275614B (en, 2012)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2172183A1 (en) * 1995-03-29 1996-09-30 Kazumi Ogata Piperazine derivative
WO1998033771A1 (fr) * 1997-01-30 1998-08-06 Senju Pharmaceutical Co., Ltd. Derives d'hydroquinone
AU754656B2 (en) * 1997-10-31 2002-11-21 Asubio Pharma Co., Ltd. Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1236523C2 (de) * 1962-02-15 1975-06-12 Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim Verfahren zur herstellung von basischen phenylaethern und deren salzen
GB1123258A (en) * 1965-09-15 1968-08-14 Ici Ltd Alkanolamine derivatives
NL301580A (en, 2012) * 1962-12-11
US3211735A (en) * 1963-01-14 1965-10-12 Ciba Geigy Corp N-aryl-n'-oxyalkyldiazacycloalkanes
GB1069345A (en) * 1963-07-19 1967-05-17 Ici Ltd New alkanolamine derivatives
GB2044251B (en) * 1978-12-01 1983-03-23 Bristol Myers Co Phenoxypropanolamine derivatives
JPS58164583A (ja) * 1982-03-18 1983-09-29 Nippon Shinyaku Co Ltd フエノキシプロパノ−ルアミン誘導体
US4652584A (en) * 1984-07-13 1987-03-24 Mcneilab, Inc. Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
ES8609190A1 (es) * 1985-02-07 1986-07-16 Pharma Investi S A Un procedimiento para preparar eteres fenolicos
US4665094A (en) * 1985-08-29 1987-05-12 Merck & Co., Inc. Oculoselective beta-blockers for treatment of elevated intraocular pressure
FR2672594B1 (fr) * 1991-02-08 1994-07-01 Synthelabo Derives d'ethers de phenols, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
TW275614B (en, 2012) 1996-05-11
KR940019671A (ko) 1994-09-14
EP0611748A1 (en) 1994-08-24
US5504087A (en) 1996-04-02

Similar Documents

Publication Publication Date Title
US3813384A (en) Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
US4234584A (en) Substituted phenylpiperazine derivatives
EP0533240A2 (en) Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US4613598A (en) Piperazine derivatives and their acid addition salts
US4191765A (en) 1-Aryloxy-2-hydroxy-3-aminopropanes
EP0524742A2 (en) Benzo(a)fluorene compounds
US4381398A (en) Amino-alcohol derivatives
US4145427A (en) N- 1-(3-Benzoyl-propyl)-4-piperidyl!-sulfonic acid amides and salts thereof
CA1116598A (en) 3-indolyl-tertiary butylaminopropanols
US3983239A (en) Hexahydro-γ-carboline derivatives and their salts
CA2115332A1 (en) Propanolamine derivatives
US3856794A (en) 1-phenoxy-3-arylpiperazinyl-2-propanol hypotensives
CA1227797A (en) Aryloxy-n-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity
EP0182572B1 (en) Novel crystalline form of benzothiazine dioxide salt
US3657276A (en) Dibenzo (c f) thiazepine (1 2) compounds
US4246260A (en) Substituted omicron-phenylenediamine derivatives, process for their preparation and their use as medicaments
CZ281377B6 (cs) Thiadiazinony, způsob jejich výroby a farmaceutické přípravky na jejich bázi
EP0039919B1 (en) Benzoxazole and benzothiazole derivatives with anti-allergic activity
EP0034894B1 (en) 2-(1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, processes for their preparation, intermediates used in the processes and the preparation thereof and pharmaceutical compositions containing the derivatives
EP0161498A1 (en) Phenylpiperazine derivatives and their acid addition salts
EP0408714B1 (en) Heterocyclic sulphonylnitromethanes, process for their preparation and pharmaceutical compositions
US3850947A (en) 3-thiazol-4'-oxy-aminopropanol cardiovascular agents
EP0127182B1 (en) 1-phenylalkyl-4-(mercapto and carbamylthio)alkyl-piperazines and -homopiperazines and their use in the treatment of allergic diseases
US3700663A (en) Dibenzothiazepine ethers
CA1083151A (en) Naphthalenone phthalazinylhydrazones

Legal Events

Date Code Title Description
FZDE Dead