CA2102804A1 - Oligonucleotides a extremite 3' bloquee - Google Patents

Oligonucleotides a extremite 3' bloquee

Info

Publication number
CA2102804A1
CA2102804A1 CA002102804A CA2102804A CA2102804A1 CA 2102804 A1 CA2102804 A1 CA 2102804A1 CA 002102804 A CA002102804 A CA 002102804A CA 2102804 A CA2102804 A CA 2102804A CA 2102804 A1 CA2102804 A1 CA 2102804A1
Authority
CA
Canada
Prior art keywords
oligonucleotides
oligonucleotide
therapeutic composition
capped
oligonucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002102804A
Other languages
English (en)
Inventor
Sudhir Agrawal
Jamal Temsamani
Jin-Yan Tang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2102804A1 publication Critical patent/CA2102804A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002102804A 1991-05-10 1992-05-08 Oligonucleotides a extremite 3' bloquee Abandoned CA2102804A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69856891A 1991-05-10 1991-05-10
US698,568 1991-05-10

Publications (1)

Publication Number Publication Date
CA2102804A1 true CA2102804A1 (fr) 1992-11-11

Family

ID=24805802

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002102804A Abandoned CA2102804A1 (fr) 1991-05-10 1992-05-08 Oligonucleotides a extremite 3' bloquee

Country Status (4)

Country Link
EP (1) EP0588881A1 (fr)
JP (1) JPH07501314A (fr)
CA (1) CA2102804A1 (fr)
WO (1) WO1992020697A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346614B1 (en) 1992-07-23 2002-02-12 Hybridon, Inc. Hybrid oligonucleotide phosphorothioates
TW244371B (fr) * 1992-07-23 1995-04-01 Tri Clover Inc
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
US5858988A (en) * 1993-02-24 1999-01-12 Wang; Jui H. Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
GB9304618D0 (en) * 1993-03-06 1993-04-21 Ciba Geigy Ag Chemical compounds
DE4338704A1 (de) * 1993-11-12 1995-05-18 Hoechst Ag Stabilisierte Oligonucleotide und deren Verwendung
DE19502912A1 (de) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
US5888737A (en) 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
WO2000027795A1 (fr) 1998-11-12 2000-05-18 Invitrogen Corporation Reactifs de transfection
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000040592A1 (fr) * 1998-12-30 2000-07-13 Oligos Etc. Inc. Acides nucleiques a extremites bloquees, squelette modifie et stabilite acide et leurs utilisations therapeutiques
US6627215B1 (en) 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
WO2016011203A1 (fr) 2014-07-15 2016-01-21 Life Technologies Corporation Compositions comprenant des agrégats lipidiques et procédés d'administration efficace de molécules dans des cellules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE126518T1 (de) * 1985-03-28 1995-09-15 Chiron Corp 0,0'-dicyanoethyl-phosphoramidite, verfahren zu deren herstellung und ihre verwendung in phosphorylierungsreaktionen.
FR2582653B1 (fr) * 1985-05-30 1987-08-14 Centre Nat Rech Scient Nouveaux composes de couplage, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
NL8700724A (nl) * 1987-03-27 1988-10-17 Univ Eindhoven Tech Poly(deoxyribonucleotiden), farmaceutische samenstellingen, gebruik en bereiding van de poly(deoxyribonucleotiden).
ATE151467T1 (de) * 1987-11-30 1997-04-15 Univ Iowa Res Found Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
AU5418290A (en) * 1989-03-31 1990-11-05 University Patents Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
US5149798A (en) * 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses

Also Published As

Publication number Publication date
JPH07501314A (ja) 1995-02-09
WO1992020697A1 (fr) 1992-11-26
EP0588881A1 (fr) 1994-03-30

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead