CA2099503A1 - Alpha-l-iduronidase synthetique et sequences de genes la codant - Google Patents
Alpha-l-iduronidase synthetique et sequences de genes la codantInfo
- Publication number
- CA2099503A1 CA2099503A1 CA002099503A CA2099503A CA2099503A1 CA 2099503 A1 CA2099503 A1 CA 2099503A1 CA 002099503 A CA002099503 A CA 002099503A CA 2099503 A CA2099503 A CA 2099503A CA 2099503 A1 CA2099503 A1 CA 2099503A1
- Authority
- CA
- Canada
- Prior art keywords
- iduronidase
- alpha
- sequences encoding
- genetic sequences
- encoding same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK949091 | 1991-11-14 | ||
AUPK9490/91 | 1991-11-14 | ||
PCT/AU1992/000611 WO1993010244A1 (fr) | 1991-11-14 | 1992-11-12 | α-L IDURONIDASE SYNTHETIQUE ET SEQUENCES GENETIQUES LA CODANT |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2099503A1 true CA2099503A1 (fr) | 1993-05-15 |
CA2099503C CA2099503C (fr) | 2007-10-09 |
Family
ID=3775823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002099503A Expired - Lifetime CA2099503C (fr) | 1991-11-14 | 1992-11-12 | Alpha-l-iduronidase synthetique et sequences de genes la codant |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0578790A4 (fr) |
JP (1) | JPH06504449A (fr) |
KR (1) | KR930703447A (fr) |
AU (1) | AU649897B2 (fr) |
CA (1) | CA2099503C (fr) |
NZ (1) | NZ245123A (fr) |
WO (1) | WO1993010244A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002514429A (ja) * | 1998-05-13 | 2002-05-21 | ハーバー−ユーシーエルエー | 組換えα−L−イズロニダーゼ、その生成及び精製方法及びその欠損により引き起こされる疾病の治療方法 |
US6569661B1 (en) | 1999-11-12 | 2003-05-27 | Biomarin Pharmaceutical Inc. | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
US6426208B1 (en) | 1999-11-12 | 2002-07-30 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
GB0606190D0 (en) | 2006-03-28 | 2006-05-10 | Isis Innovation | Construct |
US8679478B2 (en) | 2010-10-04 | 2014-03-25 | Duke University | Methods of lysosomal storage disease therapy |
WO2012054723A2 (fr) | 2010-10-22 | 2012-04-26 | Opko Curna Llc | Traitement de maladies associées à l'alpha-l-iduronidase (idua) par inhibition du transcrit antisens endogène de idua |
US10940125B2 (en) | 2015-09-18 | 2021-03-09 | Duke University | Methods and compositions for the treatment of steatosis-associated disorders |
EP3576768A4 (fr) * | 2017-01-31 | 2020-11-04 | REGENXBIO Inc. | Traitement de la mucopolysaccharidose i avec une alpha-l-iduronidase glycosylée entièrement humaine (idua) |
WO2019010335A1 (fr) | 2017-07-06 | 2019-01-10 | The Trustees Of The University Of Pennsylvania | Thérapie génique médiée par aav9 pour traiter la mucopolysaccharidose de type i |
EP3684938A1 (fr) | 2017-09-22 | 2020-07-29 | The Trustees of the University of Pennsylvania | Thérapie génique pour le traitement de la mucopolysaccharidose de type ii |
-
1992
- 1992-11-12 KR KR1019930702107A patent/KR930703447A/ko not_active Application Discontinuation
- 1992-11-12 WO PCT/AU1992/000611 patent/WO1993010244A1/fr not_active Application Discontinuation
- 1992-11-12 CA CA002099503A patent/CA2099503C/fr not_active Expired - Lifetime
- 1992-11-12 EP EP9292923074A patent/EP0578790A4/fr not_active Withdrawn
- 1992-11-12 AU AU29141/92A patent/AU649897B2/en not_active Ceased
- 1992-11-12 JP JP5508825A patent/JPH06504449A/ja active Pending
- 1992-11-13 NZ NZ245123A patent/NZ245123A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ245123A (en) | 1995-05-26 |
AU649897B2 (en) | 1994-06-02 |
WO1993010244A1 (fr) | 1993-05-27 |
JPH06504449A (ja) | 1994-05-26 |
KR930703447A (ko) | 1993-11-30 |
EP0578790A4 (fr) | 1994-11-02 |
CA2099503C (fr) | 2007-10-09 |
AU2914192A (en) | 1993-06-15 |
EP0578790A1 (fr) | 1994-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |