CA2099503C - Alpha-l-iduronidase synthetique et sequences de genes la codant - Google Patents
Alpha-l-iduronidase synthetique et sequences de genes la codant Download PDFInfo
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- CA2099503C CA2099503C CA002099503A CA2099503A CA2099503C CA 2099503 C CA2099503 C CA 2099503C CA 002099503 A CA002099503 A CA 002099503A CA 2099503 A CA2099503 A CA 2099503A CA 2099503 C CA2099503 C CA 2099503C
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- idua
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01076—L-Iduronidase (3.2.1.76)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPK9490/91 | 1991-11-14 | ||
| AUPK949091 | 1991-11-14 | ||
| PCT/AU1992/000611 WO1993010244A1 (fr) | 1991-11-14 | 1992-11-12 | α-L IDURONIDASE SYNTHETIQUE ET SEQUENCES GENETIQUES LA CODANT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2099503A1 CA2099503A1 (fr) | 1993-05-15 |
| CA2099503C true CA2099503C (fr) | 2007-10-09 |
Family
ID=3775823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002099503A Expired - Lifetime CA2099503C (fr) | 1991-11-14 | 1992-11-12 | Alpha-l-iduronidase synthetique et sequences de genes la codant |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0578790A4 (fr) |
| JP (1) | JPH06504449A (fr) |
| KR (1) | KR930703447A (fr) |
| AU (1) | AU649897B2 (fr) |
| CA (1) | CA2099503C (fr) |
| NZ (1) | NZ245123A (fr) |
| WO (1) | WO1993010244A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1300323A (zh) * | 1998-05-13 | 2001-06-20 | 加州大学洛杉矶分校港口研究和教育院 | 重组α－L－艾杜糖苷酸酶,其生产和纯化的方法以及治疗其缺乏导致的疾病的方法 |
| US6569661B1 (en) | 1999-11-12 | 2003-05-27 | Biomarin Pharmaceutical Inc. | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
| US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| US6426208B1 (en) | 1999-11-12 | 2002-07-30 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof |
| GB0606190D0 (en) | 2006-03-28 | 2006-05-10 | Isis Innovation | Construct |
| US8679478B2 (en) | 2010-10-04 | 2014-03-25 | Duke University | Methods of lysosomal storage disease therapy |
| CA2815212A1 (fr) | 2010-10-22 | 2012-04-26 | Curna, Inc. | Traitement de maladies associees a l'alpha-l-iduronidase (idua) par inhibition du transcrit antisens endogene de idua |
| WO2017049157A1 (fr) | 2015-09-18 | 2017-03-23 | Duke University | Méthodes et compositions pour le traitement de troubles associés à une stéatose |
| AU2018216807A1 (en) * | 2017-01-31 | 2019-08-08 | Regenxbio Inc. | Treatment of mucopolysaccharidosis I with fully-human glycosylated human alpha-l-iduronidase (IDUA) |
| EP3676385A1 (fr) | 2017-07-06 | 2020-07-08 | The Trustees of The University of Pennsylvania | Thérapie génique médiée par aav9 pour traiter la mucopolysaccharidose de type i |
| SG11202002457RA (en) | 2017-09-22 | 2020-04-29 | Univ Pennsylvania | Gene therapy for treating mucopolysaccharidosis type ii |
-
1992
- 1992-11-12 CA CA002099503A patent/CA2099503C/fr not_active Expired - Lifetime
- 1992-11-12 JP JP5508825A patent/JPH06504449A/ja active Pending
- 1992-11-12 WO PCT/AU1992/000611 patent/WO1993010244A1/fr not_active Ceased
- 1992-11-12 AU AU29141/92A patent/AU649897B2/en not_active Ceased
- 1992-11-12 KR KR1019930702107A patent/KR930703447A/ko not_active Withdrawn
- 1992-11-12 EP EP9292923074A patent/EP0578790A4/fr not_active Withdrawn
- 1992-11-13 NZ NZ245123A patent/NZ245123A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0578790A4 (fr) | 1994-11-02 |
| KR930703447A (ko) | 1993-11-30 |
| CA2099503A1 (fr) | 1993-05-15 |
| EP0578790A1 (fr) | 1994-01-19 |
| WO1993010244A1 (fr) | 1993-05-27 |
| NZ245123A (en) | 1995-05-26 |
| JPH06504449A (ja) | 1994-05-26 |
| AU649897B2 (en) | 1994-06-02 |
| AU2914192A (en) | 1993-06-15 |
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