CA2095832A1 - Ions de metaux de transition et de terres rares, a l'interieur d'un tamis moleculaire, agents de contraste pour le tractus gastro-intestinal - Google Patents

Ions de metaux de transition et de terres rares, a l'interieur d'un tamis moleculaire, agents de contraste pour le tractus gastro-intestinal

Info

Publication number
CA2095832A1
CA2095832A1 CA2095832A CA2095832A CA2095832A1 CA 2095832 A1 CA2095832 A1 CA 2095832A1 CA 2095832 A CA2095832 A CA 2095832A CA 2095832 A CA2095832 A CA 2095832A CA 2095832 A1 CA2095832 A1 CA 2095832A1
Authority
CA
Canada
Prior art keywords
molecular sieve
enclosed
pct
gastrointestinal tract
zeolite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2095832A
Other languages
English (en)
Other versions
CA2095832C (fr
Inventor
Kenneth J. Balkus, Jr.
A. Dean Sherry
Stuart W. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Kenneth J. Balkus, Jr.
A. Dean Sherry
Board Of Regents, The University Of Texas System
Stuart W. Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kenneth J. Balkus, Jr., A. Dean Sherry, Board Of Regents, The University Of Texas System, Stuart W. Young filed Critical Kenneth J. Balkus, Jr.
Publication of CA2095832A1 publication Critical patent/CA2095832A1/fr
Application granted granted Critical
Publication of CA2095832C publication Critical patent/CA2095832C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/189—Host-guest complexes, e.g. cyclodextrins
    • A61K49/1893—Molecular sieves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

L'invention se rapporte à un procédé d'utilisation d'ions paramagnétiques inclus dans un tamis moléculaire, en tant qu'agents de contraste ou d'accentuation de la brillance de l'image. En particulier, le gadolinium trivalent compris dans la zéolithe est efficace dans les examens effectués par résonnance magnétique, de la totalité des voies gastrointestinales, du fait qu'il permet de produire d'excellentes images. On peut administrer de façon appropriée les complexes de gadolinium compris dans la zéolithe, sans effets secondaires de diarrhées. On peut inclure d'autres ions de métaux de transition, y compris le manganèse bivalent, dans tout tamis moléculaire approprié possédant des propriétés d'échange d'ions suffisantes à l'échange du métal sélectionné. L'ion métallique paramagnétique échangé peut être un ion libre à l'intérieur de la structure zéolithe ou un ion lié à un chélatant. De façon alternative, on peut inclure un ion métallique paramagnétique en tant que partie d'une structure de tamis moléculaire.
CA002095832A 1990-12-07 1991-12-06 Ions de metaux de transition et de terres rares, a l'interieur d'un tamis moleculaire, agents de contraste pour le tractus gastro-intestinal Expired - Fee Related CA2095832C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/624,106 US5122363A (en) 1990-12-07 1990-12-07 Zeolite-enclosed transistion and rare earth metal ions as contrast agents for the gastrointestinal tract
US624,106 1990-12-07
PCT/US1991/009222 WO1992010213A1 (fr) 1990-12-07 1991-12-06 Ion paramagnetique de diagnostic inclus dans un tamis moleculaire

Publications (2)

Publication Number Publication Date
CA2095832A1 true CA2095832A1 (fr) 1992-06-08
CA2095832C CA2095832C (fr) 2000-02-08

Family

ID=24500680

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095832A Expired - Fee Related CA2095832C (fr) 1990-12-07 1991-12-06 Ions de metaux de transition et de terres rares, a l'interieur d'un tamis moleculaire, agents de contraste pour le tractus gastro-intestinal

Country Status (12)

Country Link
US (3) US5122363A (fr)
EP (1) EP0560910B1 (fr)
JP (1) JP2716094B2 (fr)
AT (1) ATE135237T1 (fr)
AU (1) AU652213B2 (fr)
CA (1) CA2095832C (fr)
DE (1) DE69117973T2 (fr)
DK (1) DK0560910T3 (fr)
ES (1) ES2085617T3 (fr)
GR (1) GR3020191T3 (fr)
SG (1) SG43963A1 (fr)
WO (1) WO1992010213A1 (fr)

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Also Published As

Publication number Publication date
EP0560910A1 (fr) 1993-09-22
JP2716094B2 (ja) 1998-02-18
US5122363A (en) 1992-06-16
WO1992010213A1 (fr) 1992-06-25
AU9144291A (en) 1992-07-08
ES2085617T3 (es) 1996-06-01
CA2095832C (fr) 2000-02-08
SG43963A1 (en) 1997-11-14
GR3020191T3 (en) 1996-09-30
DE69117973T2 (de) 1996-09-12
DE69117973D1 (de) 1996-04-18
DK0560910T3 (da) 1996-07-22
US5429814A (en) 1995-07-04
AU652213B2 (en) 1994-08-18
ATE135237T1 (de) 1996-03-15
JPH06509544A (ja) 1994-10-27
US5277896A (en) 1994-01-11
EP0560910B1 (fr) 1996-03-13

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