CA2090321A1 - Therapeutically useful 2-aminotetralin derivatives - Google Patents
Therapeutically useful 2-aminotetralin derivativesInfo
- Publication number
- CA2090321A1 CA2090321A1 CA002090321A CA2090321A CA2090321A1 CA 2090321 A1 CA2090321 A1 CA 2090321A1 CA 002090321 A CA002090321 A CA 002090321A CA 2090321 A CA2090321 A CA 2090321A CA 2090321 A1 CA2090321 A1 CA 2090321A1
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- therapeutically useful
- het
- cycloalkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Abstract
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of for-mula (I), wherein R is hydrogen or halogen, wherein R1 is hydrogen, OR4, SR4, CONR5R6, CN, het, C(O)het, CF3, SO2NR5R6, 5-oxazolyl, CSNR5R6, OSO2CF3, wherein R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, (CH2)m-cycloalkyl; (CH2)m-cycloalkenyl, (CH2)m-aryl, (CH2)m-CO2R4, (CH2)m-OR4, wherein R4, R5 and R6 are independ-ently hydrogen, alkyl, alkenyl, cycloalkyl, and wherein X is (CH2)n, m = 0-4, n = 4-8, p = 0,1. These compounds are use-ful to treat central nervous system disorders, hypertension, diabetes, sexual impotency and to control appetite.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59691690A | 1990-10-12 | 1990-10-12 | |
US596,916 | 1990-10-12 | ||
US59692390A | 1990-10-15 | 1990-10-15 | |
US596,923 | 1990-10-15 | ||
PCT/US1991/006863 WO1992006967A1 (en) | 1990-10-12 | 1991-09-26 | Therapeutically useful 2-aminotetralin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2090321A1 true CA2090321A1 (en) | 1992-04-13 |
CA2090321C CA2090321C (en) | 2002-04-09 |
Family
ID=27082677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002090321A Expired - Fee Related CA2090321C (en) | 1990-10-12 | 1991-09-26 | Therapeutically useful 2-aminotetralin derivatives |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0552246A1 (en) |
JP (1) | JPH06502165A (en) |
KR (1) | KR100207876B1 (en) |
CA (1) | CA2090321C (en) |
HU (1) | HU211928A9 (en) |
WO (1) | WO1992006967A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301732D0 (en) * | 1993-05-18 | 1993-05-18 | Haakan Wilhelm Wikstroem | NEW CENTRALLY ACTING 5-, 6-, 7-, AND 8-SUBSTITUTED SULPHONE ESTERS OF N-MONOSUBSTITUTED 2-AMINOTETRALINS |
US5457121A (en) * | 1994-09-02 | 1995-10-10 | Eli Lilly And Company | Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake |
US6844368B1 (en) | 1998-12-22 | 2005-01-18 | Edward Roberts | Compounds useful in pain management |
NZ569608A (en) * | 2006-01-06 | 2011-09-30 | Sepracor Inc | Tetralone-based monoamine reuptake inhibitors |
WO2009121872A2 (en) | 2008-04-01 | 2009-10-08 | Abbott Gmbh & Co. Kg | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
AR075442A1 (en) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USES IN THERAPY |
US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9045459B2 (en) | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
MX2014001457A (en) | 2011-08-05 | 2014-08-21 | Abbvie Deutschland | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives, pharmaceutical compositions containing them, and their use in therapy. |
CA2853254A1 (en) | 2011-11-18 | 2013-05-23 | Abbvie Inc. | N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
WO2015055771A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
CA2924689A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2352020A (en) * | 1939-11-17 | 1944-06-20 | Scheuing Georg | Process for the production of analgetically active tetrahydronaphthols |
GB2037288B (en) * | 1977-08-04 | 1982-07-14 | Squibb & Sons Inc | Naphthalene derivatives |
SE8004002L (en) * | 1980-05-29 | 1981-11-30 | Arvidsson Folke Lars Erik | THERAPEUTICALLY APPLICABLE TETRALIN DERIVATIVES |
US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
-
1991
- 1991-09-26 EP EP91918589A patent/EP0552246A1/en not_active Withdrawn
- 1991-09-26 JP JP3517898A patent/JPH06502165A/en active Pending
- 1991-09-26 WO PCT/US1991/006863 patent/WO1992006967A1/en not_active Application Discontinuation
- 1991-09-26 CA CA002090321A patent/CA2090321C/en not_active Expired - Fee Related
- 1991-09-26 KR KR1019930701096A patent/KR100207876B1/en not_active IP Right Cessation
-
1995
- 1995-06-23 HU HU95P/P00417P patent/HU211928A9/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2090321C (en) | 2002-04-09 |
EP0552246A1 (en) | 1993-07-28 |
WO1992006967A1 (en) | 1992-04-30 |
JPH06502165A (en) | 1994-03-10 |
KR100207876B1 (en) | 1999-07-15 |
HU211928A9 (en) | 1996-01-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2090321A1 (en) | Therapeutically useful 2-aminotetralin derivatives | |
DK0476016T3 (en) | CNS-active 8-heterocyclyl-2-aminotetraline derivatives | |
FI113651B (en) | Process for the preparation of therapeutically useful bentsimidazole compounds | |
DE122004000039I1 (en) | Gaba and L-glutaminase analogues for the treatment of epilepsy | |
ES8306708A1 (en) | Therapeutically useful 1-alkyl-2-aminotetralin derivatives. | |
US4711958A (en) | Morpholine containing amino acid derivatives | |
MY106401A (en) | N-imidazolyl-and-n-imidazolymethyl-derivatives of substituted bicyclic compounds. | |
DE69030665D1 (en) | (1,2N) AND (3,2N) -BOXYCLICAL-2-AMINO-TETRALINE DERIVATIVES | |
ZA909043B (en) | Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders | |
IT1211792B (en) | O-ALCANOIL ACID DERIVATIVES 3 AMINO 2- HYDROXYPROPANSULPHONIC ANTICONVULSIVE ADAPTITY AND THEIR PHARMACEUTICAL COMPOSITIONS FOR THE THERAPEUTIC TREATMENT OF EPILEPSY | |
EA199700287A1 (en) | BENZAMIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | |
DE69206607T2 (en) | TREATMENT OF COGNITIVE DISORDERS. | |
GR3006432T3 (en) | ||
MY123317A (en) | Synthesis of chiral beta-amino acids | |
FI103970B1 (en) | A process for the preparation of 3- (1,2-benzisoxazol-3-yl) -4-pyridinamine and derivatives thereof for the treatment of pain and for the treatment of dermatological and memory disorders | |
FI904184A0 (en) | Analogous Process for the Preparation of Therapeutically Useful Oxodibenzoxepine and Oxothienobenzoxepinalkylamine and Alkanoic Acid Amide Derivatives | |
EP0575500A1 (en) | Hiv protease inhibitors | |
ES8704922A2 (en) | Improvements to the subject matter of patent of invention no. 541,911 relating to Process for obtaining new [alpha]- (alkylaminopropionyl)-thiophen derivatives substituted in the thiophen ring |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |