CA2088100C - Methods and apparatus for isotopic analysis - Google Patents
Methods and apparatus for isotopic analysisInfo
- Publication number
- CA2088100C CA2088100C CA002088100A CA2088100A CA2088100C CA 2088100 C CA2088100 C CA 2088100C CA 002088100 A CA002088100 A CA 002088100A CA 2088100 A CA2088100 A CA 2088100A CA 2088100 C CA2088100 C CA 2088100C
- Authority
- CA
- Canada
- Prior art keywords
- analyte
- isotope
- isotopes
- bearing species
- wavelengths
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 58
- 230000000155 isotopic effect Effects 0.000 title claims abstract description 28
- 238000004458 analytical method Methods 0.000 title description 8
- 230000007704 transition Effects 0.000 claims abstract description 131
- 239000012491 analyte Substances 0.000 claims abstract description 101
- 230000005281 excited state Effects 0.000 claims abstract description 30
- 238000012544 monitoring process Methods 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 238000012360 testing method Methods 0.000 claims abstract description 26
- 230000004044 response Effects 0.000 claims description 32
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 28
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 28
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 26
- 230000005855 radiation Effects 0.000 claims description 23
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 18
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical class O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
- 230000005707 optogalvanic effect Effects 0.000 abstract description 14
- 239000000700 radioactive tracer Substances 0.000 abstract description 13
- 230000003993 interaction Effects 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 6
- 241000894007 species Species 0.000 description 58
- 239000007789 gas Substances 0.000 description 22
- 238000010521 absorption reaction Methods 0.000 description 11
- 238000012806 monitoring device Methods 0.000 description 9
- 125000004429 atom Chemical group 0.000 description 8
- 230000002285 radioactive effect Effects 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 7
- 239000004202 carbamide Substances 0.000 description 7
- 230000005283 ground state Effects 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000004364 calculation method Methods 0.000 description 6
- 239000012159 carrier gas Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- 229910002091 carbon monoxide Inorganic materials 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 238000004949 mass spectrometry Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 239000012857 radioactive material Substances 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 229910052770 Uranium Inorganic materials 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003989 dielectric material Substances 0.000 description 2
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- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
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- 244000005700 microbiome Species 0.000 description 2
- 238000010895 photoacoustic effect Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000012306 spectroscopic technique Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- PFNQVRZLDWYSCW-UHFFFAOYSA-N (fluoren-9-ylideneamino) n-naphthalen-1-ylcarbamate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1=NOC(=O)NC1=CC=CC2=CC=CC=C12 PFNQVRZLDWYSCW-UHFFFAOYSA-N 0.000 description 1
- PCLIRWBVOVZTOK-UHFFFAOYSA-M 2-(1-methylpyrrolidin-1-ium-1-yl)ethyl 2-hydroxy-2,2-diphenylacetate;iodide Chemical compound [I-].C=1C=CC=CC=1C(O)(C=1C=CC=CC=1)C(=O)OCC[N+]1(C)CCCC1 PCLIRWBVOVZTOK-UHFFFAOYSA-M 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- -1 antibodies Proteins 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 238000009739 binding Methods 0.000 description 1
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- 229910052729 chemical element Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000007705 chemical test Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000001307 laser spectroscopy Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000001630 optogalvanic spectroscopy Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/626—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using heat to ionise a gas
- G01N27/628—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using heat to ionise a gas and a beam of energy, e.g. laser enhanced ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/623—Ion mobility spectrometry combined with mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/68—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence using high frequency electric fields
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/204998—Inorganic carbon compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/829,416 US5394236A (en) | 1992-02-03 | 1992-02-03 | Methods and apparatus for isotopic analysis |
| US07/829,416 | 1992-02-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2088100A1 CA2088100A1 (en) | 1993-08-04 |
| CA2088100C true CA2088100C (en) | 1997-11-25 |
Family
ID=25254486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002088100A Expired - Fee Related CA2088100C (en) | 1992-02-03 | 1993-01-26 | Methods and apparatus for isotopic analysis |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5394236A (enExample) |
| EP (1) | EP0556614B1 (enExample) |
| JP (1) | JP3338497B2 (enExample) |
| KR (1) | KR970007066B1 (enExample) |
| CN (1) | CN1043685C (enExample) |
| AT (1) | ATE224538T1 (enExample) |
| AU (1) | AU659905B2 (enExample) |
| CA (1) | CA2088100C (enExample) |
| DE (1) | DE69332297T2 (enExample) |
| TW (1) | TW254850B (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5394236A (en) * | 1992-02-03 | 1995-02-28 | Rutgers, The State University | Methods and apparatus for isotopic analysis |
| US5412467A (en) * | 1993-03-24 | 1995-05-02 | Praxair Technology, Inc. | Gas emission spectrometer and method |
| US5900533A (en) * | 1995-08-03 | 1999-05-04 | Trw Inc. | System and method for isotope ratio analysis and gas detection by photoacoustics |
| WO1997026827A1 (en) * | 1996-01-26 | 1997-07-31 | Battelle Memorial Institute | Optical non-radioactive breath analysis |
| US5818580A (en) * | 1996-03-12 | 1998-10-06 | Rutgers, The State University | Simultaneous multisample analysis and apparatus therefor |
| US5706082A (en) * | 1996-05-14 | 1998-01-06 | Alimenterics Inc. | Optogalvanic spectroscopy with phase independent detection |
| US5747809A (en) * | 1996-06-11 | 1998-05-05 | Sri International | NDIR apparatus and method for measuring isotopic ratios in gaseous samples |
| US5944670A (en) * | 1996-12-02 | 1999-08-31 | Oridion Medical Ltd. | Breath test for the diagnosis of bacterial infection |
| US6186958B1 (en) | 1997-02-26 | 2001-02-13 | Oridion Medical | Breath test analyzer |
| IL121793A (en) * | 1997-09-17 | 2008-06-05 | Lewis Coleman | Isotopic gas analyzer |
| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| USRE38728E1 (en) * | 1997-09-11 | 2005-04-19 | Oridion Medical, LTD | Breath test analyzer |
| JP2001515745A (ja) | 1997-09-11 | 2001-09-25 | オリディオン・メディカル・リミテッド | ブレス検査分析装置 |
| US6284219B1 (en) | 1998-06-30 | 2001-09-04 | Phenome Sciences Inc. | In vivo determination of metabolic function for use in therapy management |
| AT408376B (de) * | 1999-04-07 | 2001-11-26 | Lendl Bernhard Dr | Verfahren zur infrarot-optischen bestimmung der konzentration zumindest eines analyten in einer flüssigen probe |
| AU5243100A (en) * | 1999-06-08 | 2000-12-28 | Oridion Medical (1987) Ltd. | Gas analyzer calibration checking device |
| US6656127B1 (en) | 1999-06-08 | 2003-12-02 | Oridion Breathid Ltd. | Breath test apparatus and methods |
| US6179691B1 (en) * | 1999-08-06 | 2001-01-30 | Taiwan Semiconductor Manufacturing Company | Method for endpoint detection for copper CMP |
| US6800855B1 (en) * | 1999-12-27 | 2004-10-05 | Nippon Sanso Corporation | Spectroscopic method for analyzing isotopes by using a semiconductor laser |
| US20010037070A1 (en) * | 2000-02-22 | 2001-11-01 | Cranley Paul E. | Personal computer breath analyzer for health-related behavior modification and method |
| US6609068B2 (en) | 2000-02-22 | 2003-08-19 | Dow Global Technologies Inc. | Personal computer breath analyzer for health-related behavior modification and method |
| US7004909B1 (en) * | 2001-03-19 | 2006-02-28 | Pranalytica, Inc. | Diagnostic method for high sensitivity detection of component concentrations in human gas emissions |
| DE60239552D1 (de) * | 2001-10-24 | 2011-05-05 | Univ California | Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser |
| EP1483399B1 (en) * | 2002-02-12 | 2008-10-29 | The Regents of the University of California | Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products |
| US6888127B2 (en) * | 2002-02-26 | 2005-05-03 | Halliburton Energy Services, Inc. | Method and apparatus for performing rapid isotopic analysis via laser spectroscopy |
| IL148468A (en) | 2002-03-03 | 2012-12-31 | Exalenz Bioscience Ltd | Breath collection system |
| CA2503681A1 (en) * | 2002-04-05 | 2003-10-23 | Marc K. Hellerstein | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| US20060094057A1 (en) * | 2002-07-30 | 2006-05-04 | Maro K. Hellerstein | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
| WO2004021863A2 (en) * | 2002-09-04 | 2004-03-18 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
| DK1546373T3 (da) * | 2002-09-13 | 2009-03-30 | Univ California | Fremgangsmåder til måling af hastigheder af revers cholesteroltransport in vivo som et indeks for antiatherogenese |
| EP1545628A4 (en) * | 2002-09-16 | 2010-07-28 | Univ California | BIOCHEMICAL METHOD FOR MEASURING THE METABOLIC FITNESS OF WOVEN OR THE WHOLE ORGANISM |
| US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| WO2004042360A2 (en) * | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US9682425B2 (en) | 2009-12-08 | 2017-06-20 | Baker Hughes Incorporated | Coated metallic powder and method of making the same |
| US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| CA2553223A1 (en) * | 2004-01-15 | 2005-08-04 | Cedars-Sinai Medical Center | System and method for expression proteomics based on isotope ratio modification |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| AU2005222430A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| US7251037B2 (en) * | 2005-03-07 | 2007-07-31 | Caleb Brett Usa, Inc. | Method to reduce background noise in a spectrum |
| US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
| TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
| EP1887342A1 (en) * | 2006-08-11 | 2008-02-13 | Geoservices | Device for quantifiying the relative contents of two isotopes of at least one specific gaseous constituent contained in a gaseous sample from a fluid related assembly and process. |
| US7616305B2 (en) * | 2006-11-30 | 2009-11-10 | Rutgers, The State University | Analytical methods and apparatus |
| WO2009108687A2 (en) * | 2008-02-25 | 2009-09-03 | University Of Utah Research Foundation | Device and system to reconstruct travel history of an individual |
| EP2344879A4 (en) * | 2008-09-15 | 2013-03-20 | Platypus Technologies Llc | DETECTION OF STEAM PHASE COMPOUNDS BY CHANGING THE PHYSICAL PROPERTIES OF A LIQUID CRYSTAL |
| KR101068996B1 (ko) * | 2008-09-18 | 2011-09-30 | 한국표준과학연구원 | 안정동위원소의 질량비를 이용한 동물의 월령 측정 방법 |
| JP5587344B2 (ja) * | 2009-02-02 | 2014-09-10 | プラネタリー・エミッションズ・マネージメント | 温室ガスフラックスを監視するためのシステム |
| US10240419B2 (en) | 2009-12-08 | 2019-03-26 | Baker Hughes, A Ge Company, Llc | Downhole flow inhibition tool and method of unplugging a seat |
| US9110008B2 (en) * | 2010-07-26 | 2015-08-18 | Los Gatos Research | Method for isotopic analysis of water in bodily fluids |
| TWI393892B (zh) * | 2010-09-20 | 2013-04-21 | Univ Nat Formosa | Detection method of electro - optical signal and its detection system |
| US8945936B2 (en) | 2011-04-06 | 2015-02-03 | Fresenius Medical Care Holdings, Inc. | Measuring chemical properties of a sample fluid in dialysis systems |
| US8631876B2 (en) | 2011-04-28 | 2014-01-21 | Baker Hughes Incorporated | Method of making and using a functionally gradient composite tool |
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1992
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- 1993-01-26 CA CA002088100A patent/CA2088100C/en not_active Expired - Fee Related
- 1993-01-28 AT AT93101294T patent/ATE224538T1/de not_active IP Right Cessation
- 1993-01-28 EP EP93101294A patent/EP0556614B1/en not_active Expired - Lifetime
- 1993-01-28 DE DE69332297T patent/DE69332297T2/de not_active Expired - Fee Related
- 1993-01-29 AU AU32114/93A patent/AU659905B2/en not_active Ceased
- 1993-02-03 CN CN93102399A patent/CN1043685C/zh not_active Expired - Fee Related
- 1993-02-03 JP JP03952293A patent/JP3338497B2/ja not_active Expired - Fee Related
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- 1993-02-10 TW TW082100897A patent/TW254850B/zh active
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1994
- 1994-10-03 US US08/317,265 patent/US5783445A/en not_active Expired - Lifetime
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- 1995-06-06 US US08/470,759 patent/US5864398A/en not_active Expired - Lifetime
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| CA2088100A1 (en) | 1993-08-04 |
| TW254850B (enExample) | 1995-08-21 |
| KR930018271A (ko) | 1993-09-21 |
| EP0556614B1 (en) | 2002-09-18 |
| DE69332297T2 (de) | 2003-02-13 |
| CN1043685C (zh) | 1999-06-16 |
| US5864398A (en) | 1999-01-26 |
| KR970007066B1 (ko) | 1997-05-02 |
| ATE224538T1 (de) | 2002-10-15 |
| JP3338497B2 (ja) | 2002-10-28 |
| AU659905B2 (en) | 1995-06-01 |
| AU3211493A (en) | 1993-08-05 |
| US5783445A (en) | 1998-07-21 |
| DE69332297D1 (de) | 2002-10-24 |
| EP0556614A1 (en) | 1993-08-25 |
| JPH0720054A (ja) | 1995-01-24 |
| US5394236A (en) | 1995-02-28 |
| CN1077284A (zh) | 1993-10-13 |
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