CA2085224A1 - Activateurs de plasminogene hybrides - Google Patents

Activateurs de plasminogene hybrides

Info

Publication number
CA2085224A1
CA2085224A1 CA002085224A CA2085224A CA2085224A1 CA 2085224 A1 CA2085224 A1 CA 2085224A1 CA 002085224 A CA002085224 A CA 002085224A CA 2085224 A CA2085224 A CA 2085224A CA 2085224 A1 CA2085224 A1 CA 2085224A1
Authority
CA
Canada
Prior art keywords
compound according
hybrid
plasminogen
chain
glu1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002085224A
Other languages
English (en)
Inventor
Jeffery H. Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2085224A1 publication Critical patent/CA2085224A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fixing For Electrophotography (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002085224A 1990-06-14 1991-06-12 Activateurs de plasminogene hybrides Abandoned CA2085224A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9013345.5 1990-06-14
GB909013345A GB9013345D0 (en) 1990-06-14 1990-06-14 Novel compounds

Publications (1)

Publication Number Publication Date
CA2085224A1 true CA2085224A1 (fr) 1991-12-15

Family

ID=10677652

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085224A Abandoned CA2085224A1 (fr) 1990-06-14 1991-06-12 Activateurs de plasminogene hybrides

Country Status (12)

Country Link
EP (1) EP0535037A1 (fr)
JP (1) JPH05506363A (fr)
KR (1) KR930701607A (fr)
AU (1) AU648567B2 (fr)
CA (1) CA2085224A1 (fr)
GB (1) GB9013345D0 (fr)
IE (1) IE911999A1 (fr)
IL (1) IL98478A0 (fr)
NZ (1) NZ238506A (fr)
PT (1) PT97983A (fr)
WO (1) WO1991019793A2 (fr)
ZA (1) ZA914520B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1135475A1 (fr) * 1998-12-02 2001-09-26 Oklahoma Medical Research Foundation Activateur de plasminogene humain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
EP0297882B1 (fr) * 1987-07-01 1993-08-25 Beecham Group Plc Activateurs de plasminogène hybrides
GB9019120D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
IE911999A1 (en) 1991-12-18
AU8068191A (en) 1992-01-07
IL98478A0 (en) 1992-07-15
AU648567B2 (en) 1994-04-28
GB9013345D0 (en) 1990-08-08
KR930701607A (ko) 1993-06-12
ZA914520B (en) 1992-12-30
PT97983A (pt) 1992-04-30
EP0535037A1 (fr) 1993-04-07
NZ238506A (en) 1993-07-27
WO1991019793A3 (fr) 1992-01-23
JPH05506363A (ja) 1993-09-22
WO1991019793A2 (fr) 1991-12-26

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US4970159A (en) Human tissue plasminogen activator consisting essentially of t-PA residues 160 to 527
US5385732A (en) Variants of tissue plasminogen activator, compositions and methods of use for same
WO1991018989A1 (fr) Mutants hybrides d'activateur de plasminogene
RU2143490C1 (ru) Бифункциональный вариант урокиназы, плазмида, содержащая синтетический структурный ген, кодирующий бифункциональную урокиназу, плазмида (варианты), способ получения плазмиды, способ получения бифункционального варианта урокиназы, тромболитическое средство
EP0297882B1 (fr) Activateurs de plasminogène hybrides
US4999194A (en) Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US5302390A (en) Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
AU648567B2 (en) Hybrid plasminogen activators
CA2145749C (fr) Derives du plasminogene activables par la thrombine
Robinson et al. A recombinant, chimeric enzyme with a novel mechanism of action leading to greater potency and selectivity than tissue-type plasminogen activator.
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Legal Events

Date Code Title Description
FZDE Discontinued