CA2083735A1 - Derives de substitution en n de 1,2,4-triazolone, utiles pour le traitement des troubles cardiovasculaires - Google Patents
Derives de substitution en n de 1,2,4-triazolone, utiles pour le traitement des troubles cardiovasculairesInfo
- Publication number
- CA2083735A1 CA2083735A1 CA002083735A CA2083735A CA2083735A1 CA 2083735 A1 CA2083735 A1 CA 2083735A1 CA 002083735 A CA002083735 A CA 002083735A CA 2083735 A CA2083735 A CA 2083735A CA 2083735 A1 CA2083735 A1 CA 2083735A1
- Authority
- CA
- Canada
- Prior art keywords
- butyl
- biphenyl
- dihydro
- ylmethyl
- tetrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52907990A | 1990-05-25 | 1990-05-25 | |
US529,079 | 1990-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2083735A1 true CA2083735A1 (fr) | 1991-11-26 |
Family
ID=24108443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002083735A Abandoned CA2083735A1 (fr) | 1990-05-25 | 1991-05-23 | Derives de substitution en n de 1,2,4-triazolone, utiles pour le traitement des troubles cardiovasculaires |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0531382A1 (fr) |
JP (1) | JPH05506443A (fr) |
AU (1) | AU7903091A (fr) |
CA (1) | CA2083735A1 (fr) |
WO (1) | WO1991018888A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5411980A (en) * | 1989-07-28 | 1995-05-02 | Merck & Co., Inc. | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists |
US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
JP3290657B2 (ja) * | 1991-05-01 | 2002-06-10 | メルク エンド カムパニー インコーポレーテッド | アンギオテンシンii拮抗剤として活性な酸性アラルキルトリアゾール誘導体 |
JP3890453B2 (ja) * | 1996-09-18 | 2007-03-07 | リードケミカル株式会社 | 新規2,4−ジオキソピロリジンおよび2,4−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬 |
GB9716446D0 (en) * | 1997-08-05 | 1997-10-08 | Agrevo Uk Ltd | Fungicides |
EP1044958A4 (fr) | 1997-11-14 | 2004-11-17 | Sumitomo Chemical Co | PROCEDE DE PRODUCTION DE tert-BUTYL 4'-METHYL-2-BIPHENYLCARBOXYLATE |
HUP0100178A3 (en) * | 1997-12-17 | 2002-12-28 | Merck & Co Inc | Tetrahydro-naphtiridinyl-imidazolydinyl-carboxylic acid derivatives and pharmaceutical compositions thereof |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (fr) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2014151206A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
CA2905435A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
EP0412594B1 (fr) * | 1989-07-28 | 1996-01-03 | Merck & Co. Inc. | Triazolinones, triazolinethiones et triazolinimines substituées comme antagonistes d'angiotensine II |
-
1991
- 1991-05-23 CA CA002083735A patent/CA2083735A1/fr not_active Abandoned
- 1991-05-23 WO PCT/US1991/003449 patent/WO1991018888A1/fr not_active Application Discontinuation
- 1991-05-23 EP EP91910101A patent/EP0531382A1/fr not_active Withdrawn
- 1991-05-23 JP JP91509457A patent/JPH05506443A/ja active Pending
- 1991-05-23 AU AU79030/91A patent/AU7903091A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0531382A1 (fr) | 1993-03-17 |
JPH05506443A (ja) | 1993-09-22 |
AU7903091A (en) | 1991-12-31 |
WO1991018888A1 (fr) | 1991-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 19941123 |