CA2079585A1 - Ligand pour le produit du gene neu - Google Patents
Ligand pour le produit du gene neuInfo
- Publication number
- CA2079585A1 CA2079585A1 CA2079585A CA2079585A CA2079585A1 CA 2079585 A1 CA2079585 A1 CA 2079585A1 CA 2079585 A CA2079585 A CA 2079585A CA 2079585 A CA2079585 A CA 2079585A CA 2079585 A1 CA2079585 A1 CA 2079585A1
- Authority
- CA
- Canada
- Prior art keywords
- pct
- sec
- activity
- tyrosine kinase
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700020302 erbB-2 Genes Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 108700020796 Oncogene Proteins 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- 102000043276 Oncogene Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 238000006471 dimerization reaction Methods 0.000 abstract 1
- 231100000673 dose–response relationship Toxicity 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/813—Cancer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50583790A | 1990-04-06 | 1990-04-06 | |
US505,837 | 1990-04-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2079585A1 true CA2079585A1 (fr) | 1991-10-07 |
CA2079585C CA2079585C (fr) | 1997-01-07 |
Family
ID=24012070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002079585A Expired - Fee Related CA2079585C (fr) | 1990-04-06 | 1991-04-04 | Ligand pour le produit du gene neu |
Country Status (7)
Country | Link |
---|---|
US (1) | US5464751A (fr) |
EP (1) | EP0527802B1 (fr) |
JP (1) | JPH0776238B2 (fr) |
AT (1) | ATE153858T1 (fr) |
CA (1) | CA2079585C (fr) |
DE (1) | DE69126430T2 (fr) |
WO (1) | WO1991015230A1 (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69229597T4 (de) * | 1991-01-14 | 2000-08-17 | Georgetown University Washingt | Wachstumsfaktor-ligand, der an den erbb-2-rezeptor bindet und die zellulären reaktionen induziert |
US5530109A (en) * | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
US7135456B1 (en) | 1991-04-10 | 2006-11-14 | Acorda Therapeutics, Inc. | Glial mitogenic factors, their preparation and use |
US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
US7094749B1 (en) | 1991-04-10 | 2006-08-22 | Acorda Therapeutics, Inc. | Glial mitogenic factors, their preparation and use |
US7285531B1 (en) | 1991-04-10 | 2007-10-23 | Acorda Therapeutics, Inc. | Method for prophylaxis or treatment of a nervous system, pathophysiological condition involving a glial growth factor sensitive cell by administration of a glial growth factor |
US7319019B1 (en) | 1991-04-10 | 2008-01-15 | Acorda Therapeutics, Inc. | Glial mitogenic factors lacking an N-terminal signal sequence |
US5367060A (en) * | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
US5834229A (en) * | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
IL101943A0 (en) * | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
US7037888B1 (en) | 1992-04-03 | 2006-05-02 | Acorda Therapeutics, Inc. | Methods for treating muscle diseases and disorders |
GB9217316D0 (en) * | 1992-08-14 | 1992-09-30 | Ludwig Inst Cancer Res | Schwann cell mitogenic factor,its preparation and use |
AU681095B2 (en) * | 1992-09-29 | 1997-08-21 | President And Fellows Of Harvard College | Trophic factor having ion channel-inducing activity in neuronal cells |
US5663144A (en) * | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
US20010023241A1 (en) * | 1998-02-04 | 2001-09-20 | Sliwkowski Mark X. | Use of heregulin as a growth factor |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
US6541214B1 (en) * | 1998-11-13 | 2003-04-01 | Oregon Heath Science University | N-terminally truncated HER-2/neu protein as a cancer prognostic indicator |
US7396810B1 (en) * | 2000-08-14 | 2008-07-08 | Oregon Health Sciences University | Compositions and methods for treating cancer by modulating HER-2 and EGF receptors |
US7393823B1 (en) | 1999-01-20 | 2008-07-01 | Oregon Health And Science University | HER-2 binding antagonists |
US7625859B1 (en) * | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
BR0012195A (pt) * | 1999-06-25 | 2002-07-23 | Genentech Inc | Método para tratar câncer de próstata num ser humano, artigo de fabricação e uso de um anticorpo que liga erbb2 |
US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
US6627196B1 (en) | 1999-08-27 | 2003-09-30 | Genentech, Inc. | Dosages for treatment with anti-ErbB2 antibodies |
AU2001259271A1 (en) * | 2000-04-28 | 2001-11-12 | Millennium Pharmaceuticals, Inc. | 14094, a novel human trypsin family member and uses thereof |
KR101135233B1 (ko) * | 2000-05-19 | 2012-04-12 | 제넨테크, 인크. | ErbB 길항제에 의한 암 치료요법에 대한 효과적인 반응의 가능성을 개선시키기 위한 유전자 검출 분석 |
EP1384161A2 (fr) * | 2000-09-07 | 2004-01-28 | The Virtual Publishing Company Ltd | Publication electronique et procedes et composants associes |
JP2006516117A (ja) * | 2002-11-21 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 抗ErbB2抗体を用いた非悪性疾病または疾患の治療 |
CA2583230A1 (fr) * | 2004-10-05 | 2006-04-20 | Oregon Health And Science University | Compositions et procedes de traitement de maladie |
-
1991
- 1991-04-04 JP JP3508011A patent/JPH0776238B2/ja not_active Expired - Fee Related
- 1991-04-04 DE DE69126430T patent/DE69126430T2/de not_active Expired - Fee Related
- 1991-04-04 EP EP91908319A patent/EP0527802B1/fr not_active Expired - Lifetime
- 1991-04-04 AT AT91908319T patent/ATE153858T1/de not_active IP Right Cessation
- 1991-04-04 WO PCT/US1991/002331 patent/WO1991015230A1/fr active IP Right Grant
- 1991-04-04 CA CA002079585A patent/CA2079585C/fr not_active Expired - Fee Related
- 1991-04-04 US US07/927,422 patent/US5464751A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69126430T2 (de) | 1997-09-18 |
DE69126430D1 (de) | 1997-07-10 |
US5464751A (en) | 1995-11-07 |
CA2079585C (fr) | 1997-01-07 |
JPH0776238B2 (ja) | 1995-08-16 |
WO1991015230A1 (fr) | 1991-10-17 |
EP0527802B1 (fr) | 1997-06-04 |
ATE153858T1 (de) | 1997-06-15 |
JPH06500072A (ja) | 1994-01-06 |
EP0527802A1 (fr) | 1993-02-24 |
EP0527802A4 (en) | 1993-05-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |