CA2071479A1 - Facteurs de maturation des megacaryocytes - Google Patents
Facteurs de maturation des megacaryocytesInfo
- Publication number
- CA2071479A1 CA2071479A1 CA002071479A CA2071479A CA2071479A1 CA 2071479 A1 CA2071479 A1 CA 2071479A1 CA 002071479 A CA002071479 A CA 002071479A CA 2071479 A CA2071479 A CA 2071479A CA 2071479 A1 CA2071479 A1 CA 2071479A1
- Authority
- CA
- Canada
- Prior art keywords
- mmf
- csf
- platelet
- megakaryocyte
- megakaryocyte maturation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000004113 cell culture Methods 0.000 description 1
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- RJYSYRSELCQCSO-UHFFFAOYSA-M cesium;2,2,2-trifluoroacetate Chemical compound [Cs+].[O-]C(=O)C(F)(F)F RJYSYRSELCQCSO-UHFFFAOYSA-M 0.000 description 1
- 230000008859 change Effects 0.000 description 1
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- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- 238000004440 column chromatography Methods 0.000 description 1
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- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
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- 239000012737 fresh medium Substances 0.000 description 1
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- 102000046949 human MSC Human genes 0.000 description 1
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- 229920002521 macromolecule Polymers 0.000 description 1
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- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
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- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 210000001778 pluripotent stem cell Anatomy 0.000 description 1
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- 229920000515 polycarbonate Polymers 0.000 description 1
- 229940057847 polyethylene glycol 600 Drugs 0.000 description 1
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- 150000003839 salts Chemical class 0.000 description 1
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- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 230000002345 thrombinlike Effects 0.000 description 1
- 108010050939 thrombocytin Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
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- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59645790A | 1990-10-12 | 1990-10-12 | |
| US596,457 | 1990-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2071479A1 true CA2071479A1 (fr) | 1992-04-13 |
Family
ID=24387345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002071479A Abandoned CA2071479A1 (fr) | 1990-10-12 | 1991-10-02 | Facteurs de maturation des megacaryocytes |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0505552A4 (fr) |
| JP (1) | JPH05503302A (fr) |
| AU (1) | AU8868891A (fr) |
| CA (1) | CA2071479A1 (fr) |
| IE (1) | IE913601A1 (fr) |
| IL (1) | IL99648A0 (fr) |
| WO (1) | WO1992006712A1 (fr) |
| ZA (1) | ZA918070B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922572A (en) | 1994-01-25 | 1999-07-13 | Human Genome Sciences, Inc. | Polynucleotides encoding haemopoietic maturation factor |
| US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
| EP0675201A1 (fr) * | 1994-03-31 | 1995-10-04 | Amgen Inc. | Compositions et procédés pour la stimulation de la croissance et la différenciation des mégacaryocytes |
| WO1998001151A1 (fr) * | 1996-07-10 | 1998-01-15 | Meiji Milk Products Co., Ltd. | Nouvelle utilisation de la famille mk comme facteur hematopoietique |
| US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US8404717B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
| US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| AP2138A (en) * | 2004-04-14 | 2010-07-22 | Celgene Corp | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes. |
| CN1968695A (zh) * | 2004-04-14 | 2007-05-23 | 细胞基因公司 | 含有用于治疗和控制骨髓发育不良综合征的免疫调节化合物的组合物和使用方法 |
| AU2015305449B2 (en) | 2014-08-22 | 2021-05-06 | Celgene Corporation | Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| GB2146335A (en) * | 1983-09-07 | 1985-04-17 | Ej Ass Inc | Wound healing compositions |
| US4894440A (en) * | 1986-09-17 | 1990-01-16 | Massachusetts Institute Of Technology | Method of isolating megakaryocyte stimulatory factor |
| IL90719A0 (en) * | 1988-06-28 | 1990-01-18 | Yissum Res Dev Co | Novel nuclei acids and polypeptides encoded thereby |
| JPH04500904A (ja) * | 1988-07-13 | 1992-02-20 | ブリガム・アンド・ウイメンズ・ホスピタル | 免疫応答のエフェクター細胞のヒトプロテオグリカンペプチドコアをコードしているポリヌクレオチド |
| JPH04506513A (ja) * | 1989-04-03 | 1992-11-12 | ジェネティックス・インスティテュート・インコーポレイテッド | 巨核球増殖促進活性 |
-
1991
- 1991-10-02 EP EP19910919689 patent/EP0505552A4/en not_active Withdrawn
- 1991-10-02 CA CA002071479A patent/CA2071479A1/fr not_active Abandoned
- 1991-10-02 WO PCT/US1991/007367 patent/WO1992006712A1/fr not_active Application Discontinuation
- 1991-10-02 JP JP3518291A patent/JPH05503302A/ja active Pending
- 1991-10-02 AU AU88688/91A patent/AU8868891A/en not_active Abandoned
- 1991-10-04 IL IL99648A patent/IL99648A0/xx unknown
- 1991-10-09 ZA ZA918070A patent/ZA918070B/xx unknown
- 1991-10-16 IE IE360191A patent/IE913601A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IE913601A1 (en) | 1992-04-22 |
| ZA918070B (en) | 1992-07-29 |
| IL99648A0 (en) | 1992-08-18 |
| EP0505552A4 (en) | 1994-06-08 |
| AU8868891A (en) | 1992-05-20 |
| WO1992006712A1 (fr) | 1992-04-30 |
| JPH05503302A (ja) | 1993-06-03 |
| EP0505552A1 (fr) | 1992-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |