CA2068222A1 - Anticorps monoclonaux - Google Patents

Anticorps monoclonaux

Info

Publication number
CA2068222A1
CA2068222A1 CA2068222A CA2068222A CA2068222A1 CA 2068222 A1 CA2068222 A1 CA 2068222A1 CA 2068222 A CA2068222 A CA 2068222A CA 2068222 A CA2068222 A CA 2068222A CA 2068222 A1 CA2068222 A1 CA 2068222A1
Authority
CA
Canada
Prior art keywords
rhesus
antibody molecules
monoclonal antibodies
chimeric antibody
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2068222A
Other languages
English (en)
Other versions
CA2068222C (fr
Inventor
Nevin Campbell Hughes-Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Blood Authority
Original Assignee
Nevin Campbell Hughes-Jones
Central Blood Laboratories Authority
National Blood Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nevin Campbell Hughes-Jones, Central Blood Laboratories Authority, National Blood Authority filed Critical Nevin Campbell Hughes-Jones
Publication of CA2068222A1 publication Critical patent/CA2068222A1/fr
Application granted granted Critical
Publication of CA2068222C publication Critical patent/CA2068222C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention décrit des séquences d'ADN encodant des régions, déterminant la complémentarité, de domaines variables d'anticorps humains anti-RhD, et leur emploi dans la production de molécules d'anticorps chimériques de recombinaison.
CA002068222A 1989-11-13 1990-11-13 Anticorps monoclonaux Expired - Lifetime CA2068222C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8925590.5 1989-11-13
GB898925590A GB8925590D0 (en) 1989-11-13 1989-11-13 Monoclonal antibodies
PCT/EP1990/001964 WO1991007492A1 (fr) 1989-11-13 1990-11-13 Anticorps monoclonaux

Publications (2)

Publication Number Publication Date
CA2068222A1 true CA2068222A1 (fr) 1991-05-14
CA2068222C CA2068222C (fr) 1999-05-11

Family

ID=10666204

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002068222A Expired - Lifetime CA2068222C (fr) 1989-11-13 1990-11-13 Anticorps monoclonaux

Country Status (11)

Country Link
US (2) US5831063A (fr)
EP (1) EP0500659B1 (fr)
AT (1) ATE148168T1 (fr)
AU (1) AU647054B2 (fr)
CA (1) CA2068222C (fr)
DE (1) DE69029808T2 (fr)
DK (1) DK0500659T3 (fr)
ES (1) ES2098274T3 (fr)
GB (1) GB8925590D0 (fr)
GR (1) GR3022847T3 (fr)
WO (1) WO1991007492A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5495002A (en) * 1984-01-31 1996-02-27 Akzo N.V. Tumor associated monoclonal antibody 123AV16
GB9020282D0 (en) * 1990-09-17 1990-10-31 Gorman Scott D Altered antibodies and their preparation
US6326488B1 (en) 1990-10-19 2001-12-04 Board Of Trustees Of University Of Illinois Gene and genetic elements associated with sensitivity to chemotherapeutic drugs
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (fr) * 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
EP0523949B1 (fr) * 1991-07-15 2003-06-25 The Wellcome Foundation Limited Production d'anticorps
FR2724182B1 (fr) * 1994-09-02 1996-12-13 Pasteur Institut Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations
TR199802692T2 (xx) 1996-06-24 1999-03-22 Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk Rhesus D antijenleri i�in spesifikli�i olan ba�lay�c� yap�lar olu�turabilen polipeptitler, bunlar� kodlayan DNA ve haz�rlanmalar� i�in i�lem ve kullan�mlar�
US7323311B2 (en) 2000-03-03 2008-01-29 Cambridge Antibody Technology Limited Methods of obtaining a specific binding member that binds eotaxin
US6946546B2 (en) 2000-03-06 2005-09-20 Cambridge Antibody Technology Limited Human antibodies against eotaxin
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
SG141239A1 (en) * 2001-01-26 2008-04-28 Selexis Sa Matrix attachment regions and methods for use thereof
WO2003000908A1 (fr) * 2001-06-21 2003-01-03 Ecole Polytechnique Federale De Lausanne Procede relatif a l'insertion d'un acide nucleique dans une cellule eucaryote
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
GB0324368D0 (en) * 2003-10-17 2003-11-19 Univ Cambridge Tech Polypeptides including modified constant regions
KR101229989B1 (ko) 2003-10-24 2013-02-06 셀렉시스 에스. 에이. Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
BRPI0820530A2 (pt) * 2007-11-13 2015-06-16 Boehringer Ingelheim Int Anticorpos monoclonais que se ligam ao hgm-csf e composições medicinais compreendendo os mesmos
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8610106D0 (en) * 1986-04-25 1986-05-29 Central Blood Lab Authority Human igm-producing heterohybridoma
AU623345B2 (en) * 1987-09-18 1992-05-14 National Blood Authority Human anti-rh(d) monoclonal antibodies
AU622417B2 (en) * 1987-09-18 1992-04-09 National Blood Authority Human anti-rh(d) monoclonal antibodies

Also Published As

Publication number Publication date
GB8925590D0 (en) 1990-01-04
ATE148168T1 (de) 1997-02-15
CA2068222C (fr) 1999-05-11
US5919910A (en) 1999-07-06
WO1991007492A1 (fr) 1991-05-30
US5831063A (en) 1998-11-03
DK0500659T3 (da) 1997-07-14
ES2098274T3 (es) 1997-05-01
AU647054B2 (en) 1994-03-17
EP0500659A1 (fr) 1992-09-02
AU6721490A (en) 1991-06-13
DE69029808T2 (de) 1997-07-10
GR3022847T3 (en) 1997-06-30
DE69029808D1 (de) 1997-03-06
EP0500659B1 (fr) 1997-01-22

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202