CA2066047A1 - Peptides et pseudo-peptides antiplaquettaires - Google Patents
Peptides et pseudo-peptides antiplaquettairesInfo
- Publication number
- CA2066047A1 CA2066047A1 CA002066047A CA2066047A CA2066047A1 CA 2066047 A1 CA2066047 A1 CA 2066047A1 CA 002066047 A CA002066047 A CA 002066047A CA 2066047 A CA2066047 A CA 2066047A CA 2066047 A1 CA2066047 A1 CA 2066047A1
- Authority
- CA
- Canada
- Prior art keywords
- aspartyl
- valine
- trifluoroacetate
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US415,006 | 1989-09-29 | ||
US07/415,006 US4952562A (en) | 1989-09-29 | 1989-09-29 | Anti-thrombotic peptides and pseudopeptides |
US53438590A | 1990-06-07 | 1990-06-07 | |
US534,385 | 1990-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2066047A1 true CA2066047A1 (fr) | 1991-03-30 |
Family
ID=27022828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002066047A Abandoned CA2066047A1 (fr) | 1989-09-29 | 1990-09-25 | Peptides et pseudo-peptides antiplaquettaires |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0494248A4 (fr) |
JP (1) | JPH05500954A (fr) |
AU (1) | AU646411B2 (fr) |
CA (1) | CA2066047A1 (fr) |
WO (1) | WO1991004746A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5037808A (en) * | 1988-07-20 | 1991-08-06 | Monsanto Co. | Indolyl platelet-aggregation inhibitors |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
MX9201416A (es) * | 1991-03-28 | 1992-10-01 | Rhone Poulenc Rorer Int | Peptidos y pseudopeptidos antitromboticos. |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE69222433D1 (de) * | 1991-11-22 | 1997-10-30 | Yeda Res & Dev | Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen |
DE4212304A1 (de) * | 1992-04-13 | 1993-10-14 | Cassella Ag | Asparaginsäurederivate, ihre Herstellung und Verwendung |
FR2693107B1 (fr) * | 1992-07-01 | 1994-09-23 | Chauvin Laboratoire | Moyens pour la prévention de la cataracte secondaire. |
US5780590A (en) * | 1993-10-15 | 1998-07-14 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
UA44258C2 (uk) * | 1993-10-15 | 2002-02-15 | Рон-Пуленк Рорер Фармасьютікалз Інк. | Антитромботичні азациклоалкілалканоілпептиди та псевдопептиди, фармацевтична композиція, що їх містить, спосіб профілактики або лікування тромбозу у ссавців (варіанти) |
US5639765A (en) * | 1995-01-17 | 1997-06-17 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss |
US5602155A (en) * | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US5681820A (en) * | 1995-05-16 | 1997-10-28 | G. D. Searle & Co. | Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis |
DE69731763T3 (de) * | 1996-11-27 | 2010-12-30 | Aventis Pharmaceuticals Inc. | Pharmazeutische Zusammenstellung, die eine Verbindung mit Anti-Xa-Eigenschaften und eine Verbindung, die ein Plakettenaggregationsantagonist ist, enthalten |
NL1005808C2 (nl) * | 1997-04-14 | 1998-10-19 | Dsm Nv | Hexahydro-aspartaamamiden en werkwijze voor de bereiding ervan. |
JP2005022976A (ja) * | 2001-07-18 | 2005-01-27 | Ajinomoto Co Inc | カルボン酸誘導体 |
FR2913685B1 (fr) * | 2007-03-15 | 2012-10-19 | Fabre Pierre Dermo Cosmetique | Nouveaux derives amino-acides gras insatures et leur utilisation dermo-cosmetologique |
JP2010515767A (ja) | 2007-01-16 | 2010-05-13 | ピエール、ファブレ、デルモ‐コスメティーク | 新規な不飽和脂肪族アミノ酸誘導体および皮膚化粧品におけるそれらの使用 |
CN108610394B (zh) * | 2018-05-07 | 2021-08-31 | 深圳市维琪医药研发有限公司 | 一种拟肽类化合物的制备纯化方法以及应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
HU201964B (en) * | 1989-01-13 | 1991-01-28 | Richter Gedeon Vegyeszet | Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same |
-
1990
- 1990-09-25 EP EP19900915350 patent/EP0494248A4/en not_active Withdrawn
- 1990-09-25 CA CA002066047A patent/CA2066047A1/fr not_active Abandoned
- 1990-09-25 WO PCT/US1990/005448 patent/WO1991004746A1/fr not_active Application Discontinuation
- 1990-09-25 AU AU65391/90A patent/AU646411B2/en not_active Ceased
- 1990-09-25 JP JP2514349A patent/JPH05500954A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU6539190A (en) | 1991-04-28 |
EP0494248A1 (fr) | 1992-07-15 |
AU646411B2 (en) | 1994-02-24 |
EP0494248A4 (en) | 1992-08-26 |
WO1991004746A1 (fr) | 1991-04-18 |
JPH05500954A (ja) | 1993-02-25 |
Similar Documents
Publication | Publication Date | Title |
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US4952562A (en) | Anti-thrombotic peptides and pseudopeptides | |
US5053392A (en) | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors | |
US5086069A (en) | Anti-thrombotic peptide and pseudopeptide derivatives | |
US5051405A (en) | Anti-thrombotic peptides and pseudopeptides | |
US5064814A (en) | Anti-thrombotic peptide and pseudopeptide derivatives | |
EP0617705B1 (fr) | Succedanes non peptidiques de la sequence arg-gly-asp, et compositions pharmaceutiques les contenant | |
AU646411B2 (en) | Anti-thrombotic peptides and pseudopeptides | |
JP3453357B2 (ja) | トロンビンの阻害剤および基質 | |
US5721214A (en) | Inhibitors of factor Xa | |
JPH02264795A (ja) | グリシン誘導体 | |
AU673497B2 (en) | Anti-thrombotic peptides and pseudopeptides | |
US5919765A (en) | Inhibitors of factor XA | |
US5332726A (en) | Antithrombotic peptides and pseudopeptides | |
AU8089691A (en) | Anti-thrombotic peptide and pseudopeptide derivatives | |
AU703854B2 (en) | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides | |
US6245743B1 (en) | Inhibitors of factor Xa | |
US5328900A (en) | Anti-thrombotic peptide and pseudopeptide derivatives | |
JP2918746B2 (ja) | ペプチド誘導体およびその用途 | |
US6797700B2 (en) | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides | |
US6046169A (en) | Inhibitors of factor XA | |
IL100130A (en) | Guanidine derivatives and pharmaceutical compositions comprising them | |
CA2107893A1 (fr) | Derives de peptides et de pseudopeptides antithrombotiques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |