CA2066047A1 - Peptides et pseudo-peptides antiplaquettaires - Google Patents

Peptides et pseudo-peptides antiplaquettaires

Info

Publication number
CA2066047A1
CA2066047A1 CA002066047A CA2066047A CA2066047A1 CA 2066047 A1 CA2066047 A1 CA 2066047A1 CA 002066047 A CA002066047 A CA 002066047A CA 2066047 A CA2066047 A CA 2066047A CA 2066047 A1 CA2066047 A1 CA 2066047A1
Authority
CA
Canada
Prior art keywords
aspartyl
valine
trifluoroacetate
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002066047A
Other languages
English (en)
Inventor
Scott I. Klein
Bruce F. Molino
Mark Czekaj
Charles Gardner
Jeffrey C. Pelletier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Rorer International Holdings Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/415,006 external-priority patent/US4952562A/en
Application filed by Individual filed Critical Individual
Publication of CA2066047A1 publication Critical patent/CA2066047A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002066047A 1989-09-29 1990-09-25 Peptides et pseudo-peptides antiplaquettaires Abandoned CA2066047A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US415,006 1989-09-29
US07/415,006 US4952562A (en) 1989-09-29 1989-09-29 Anti-thrombotic peptides and pseudopeptides
US53438590A 1990-06-07 1990-06-07
US534,385 1990-06-07

Publications (1)

Publication Number Publication Date
CA2066047A1 true CA2066047A1 (fr) 1991-03-30

Family

ID=27022828

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066047A Abandoned CA2066047A1 (fr) 1989-09-29 1990-09-25 Peptides et pseudo-peptides antiplaquettaires

Country Status (5)

Country Link
EP (1) EP0494248A4 (fr)
JP (1) JPH05500954A (fr)
AU (1) AU646411B2 (fr)
CA (1) CA2066047A1 (fr)
WO (1) WO1991004746A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
DE69222433D1 (de) * 1991-11-22 1997-10-30 Yeda Res & Dev Nicht-peptidische surrogate der arg-gly-asp sequenz und entsprechende pharmazeutische zusammensetzungen
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
FR2693107B1 (fr) * 1992-07-01 1994-09-23 Chauvin Laboratoire Moyens pour la prévention de la cataracte secondaire.
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
UA44258C2 (uk) * 1993-10-15 2002-02-15 Рон-Пуленк Рорер Фармасьютікалз Інк. Антитромботичні азациклоалкілалканоілпептиди та псевдопептиди, фармацевтична композиція, що їх містить, спосіб профілактики або лікування тромбозу у ссавців (варіанти)
US5639765A (en) * 1995-01-17 1997-06-17 G. D. Searle & Co. Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss
US5602155A (en) * 1995-01-17 1997-02-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5681820A (en) * 1995-05-16 1997-10-28 G. D. Searle & Co. Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis
DE69731763T3 (de) * 1996-11-27 2010-12-30 Aventis Pharmaceuticals Inc. Pharmazeutische Zusammenstellung, die eine Verbindung mit Anti-Xa-Eigenschaften und eine Verbindung, die ein Plakettenaggregationsantagonist ist, enthalten
NL1005808C2 (nl) * 1997-04-14 1998-10-19 Dsm Nv Hexahydro-aspartaamamiden en werkwijze voor de bereiding ervan.
JP2005022976A (ja) * 2001-07-18 2005-01-27 Ajinomoto Co Inc カルボン酸誘導体
FR2913685B1 (fr) * 2007-03-15 2012-10-19 Fabre Pierre Dermo Cosmetique Nouveaux derives amino-acides gras insatures et leur utilisation dermo-cosmetologique
JP2010515767A (ja) 2007-01-16 2010-05-13 ピエール、ファブレ、デルモ‐コスメティーク 新規な不飽和脂肪族アミノ酸誘導体および皮膚化粧品におけるそれらの使用
CN108610394B (zh) * 2018-05-07 2021-08-31 深圳市维琪医药研发有限公司 一种拟肽类化合物的制备纯化方法以及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
HU201964B (en) * 1989-01-13 1991-01-28 Richter Gedeon Vegyeszet Process for producing peptides inhibiting maturation of t-lymphocytes and activity of macrophages, as well as pharmaceutical compositions comprising same

Also Published As

Publication number Publication date
AU6539190A (en) 1991-04-28
EP0494248A1 (fr) 1992-07-15
AU646411B2 (en) 1994-02-24
EP0494248A4 (en) 1992-08-26
WO1991004746A1 (fr) 1991-04-18
JPH05500954A (ja) 1993-02-25

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US5064814A (en) Anti-thrombotic peptide and pseudopeptide derivatives
EP0617705B1 (fr) Succedanes non peptidiques de la sequence arg-gly-asp, et compositions pharmaceutiques les contenant
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JP3453357B2 (ja) トロンビンの阻害剤および基質
US5721214A (en) Inhibitors of factor Xa
JPH02264795A (ja) グリシン誘導体
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US5328900A (en) Anti-thrombotic peptide and pseudopeptide derivatives
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US6797700B2 (en) Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US6046169A (en) Inhibitors of factor XA
IL100130A (en) Guanidine derivatives and pharmaceutical compositions comprising them
CA2107893A1 (fr) Derives de peptides et de pseudopeptides antithrombotiques

Legal Events

Date Code Title Description
FZDE Dead